DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ChAT and CHAT

DIOPT Version :9

Sequence 1:NP_477004.5 Gene:ChAT / 42249 FlyBaseID:FBgn0000303 Length:721 Species:Drosophila melanogaster
Sequence 2:NP_065574.4 Gene:CHAT / 1103 HGNCID:1912 Length:748 Species:Homo sapiens


Alignment Length:668 Identity:259/668 - (38%)
Similarity:392/668 - (58%) Gaps:65/668 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 KDSIL-SIPKKWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQ 125
            |..|| .:|:|..:...|.:|.|    |||:|||.|.:|:|.|::.:..:.:..|..:::.:::|
Human   108 KTPILEKVPRKMAAKTPSSEESG----LPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQ 168

  Fly   126 FSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAH 190
            |.||.|:|..|.|.||:::|...||...||||:||::.|:.||:||:|.::|..:.|....|...
Human   169 FGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLR 233

  Fly   191 FAARLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPG------VKQDSQFL 249
            |||.|:.|:||::.:|||..:|.:.|..:...|||||.|||.|..|.|.||      |.|:|..:
Human   234 FAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIM 298

  Fly   250 PSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVPVGLLTA 314
            |       |..||:|.|.||.:.:.:..:.| :|||.::.:|:..::..|.....:..|:||||:
Human   299 P-------EPEHVIVACCNQFFVLDVVINFR-RLSEGDLFTQLRKIVKMASNEDERLPPIGLLTS 355

  Fly   315 EPRSTWARDREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETN 379
            :.||.||..|.:|.:|..|:.:|::||....::|||.|           |..       :..:|:
Human   356 DGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAP-----------GGV-------ELSDTH 402

  Fly   380 MAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYKKIEEHPDE 444
            .|.:::||||...|..|||:||::|.::..|||.|:..|||..:||.:||..|.:.|.:.:...:
Human   403 RALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHVTQSSRK 467

  Fly   445 ----DNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQV 505
                |:   ...||.|.||.|...|::|...|.:::.:.:.:.:|||.||::.:|||||||..:.
Human   468 LIRADS---VSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKC 529

  Fly   506 SPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPL 570
            |||.:||:|||||.|:|:.|||.||||||.|||..||||.||:|:.|||.:.:|:...:.| || 
Human   530 SPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAA-VP- 592

  Fly   571 ESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEM 635
                    .|.|:.           |.:.|:..||...|..|.|..||..||.|||.:..:..|:
Human   593 --------ASEKLL-----------LLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKEL 638

  Fly   636 HELFKDESYIISQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTS 700
            .|:|.||:|::|..|:||||||..:|:.|..||||.|.|||..|||.||.|:||:|:|:||::||
Human   639 PEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETS 703

  Fly   701 ASRYAKSLQDSLDIMRDL 718
            :|::||::::||..||||
Human   704 SSKFAKAVEESLIDMRDL 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ChATNP_477004.5 Carn_acyltransf 88..716 CDD:279140 247/637 (39%)
CHATNP_065574.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..89
PHA03247 <27..138 CDD:223021 13/33 (39%)
Carn_acyltransf 131..719 CDD:395612 247/637 (39%)
Coenzyme A binding 520..532 7/11 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 727..748
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158997
Domainoid 1 1.000 450 1.000 Domainoid score I514
eggNOG 1 0.900 - - E1_KOG3717
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40693
Inparanoid 1 1.050 461 1.000 Inparanoid score I1568
Isobase 1 0.950 - 0 Normalized mean entropy S2274
OMA 1 1.010 - - QHG45782
OrthoDB 1 1.010 - - D167256at33208
OrthoFinder 1 1.000 - - FOG0001049
OrthoInspector 1 1.000 - - otm40951
orthoMCL 1 0.900 - - OOG6_107067
Panther 1 1.100 - - LDO PTHR22589
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2058
SonicParanoid 1 1.000 - - X630
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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