DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and cpt1al

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001107300.1	Gene:	cpt1al / 100135089	XenbaseID:	XB-GENE-5770297	Length:	767	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	206/777 - (26%)
Similarity:	325/777 - (41%)	Gaps:	179/777 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SAAGSGPESAALFSKLRSFSIGSGPNSPQRVVSNLRGFLTHRLSNITPSDTGW----KDSILSIP 69
            |..|....||.|||....|::          :..:|..|...||.     .||    ...:.:..
Frog    98 SHQGQSIVSALLFSTGLWFAL----------IMTMRFILKQLLSY-----HGWMYEQHGKMSATT 147

  Fly    70 KKWLSTAESVDE-----FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAP 129
            |.||:..:....     :.:...||::|||.:.||:..|:.::.|:....:.:|...|.:.|..
Frog   148 KLWLALVKIFSGRNPMLYSYQAVLPRLPVPGVKETVQRYLDSVRPLMNDEEYKRMTGLAKDFEV- 211

  Fly   130 QGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSN----------PGMVFPPRRFKT 184
             .:..||..||..|.....|:...:|...:|:..|.|:.:|||          |..|...|...|
Frog   212 -NLAPRLQWYLKLKSWWAANYVSDWWEEYIYLRGRGPIMVNSNYYAMDFLYVTPTPVQAARAANT 275

  Fly   185 VHDVAHFAARLLDGILSHREMLDSGELPLERAASREKNQPL--------CMAQYYRLLGSCRRPG 241
            ||           .||.:|           |..:||:.:||        |.|||..:..:.|.||
Frog   276 VH-----------AILLYR-----------RKVTREELKPLMIQDCLPMCSAQYEHMFNTTRIPG 318

  Fly   242 VKQDS-QFLPSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAK 305
            |..|: |...       :.:|:||..:.:.:.|.:....| .|:..|:..|...:|:|    |:.
Frog   319 VDTDTIQHYA-------DSKHIVVYHKGRFFRVWVYQGGR-LLNPKELELQFQNILND----PSP 371

  Fly   306 PVP----VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGAT 366
            |.|    :..|||..|:.||:.|:......:|.:.|:|:|.|...:.|.:...|
Frog   372 PQPGEEKLAALTAGERTAWAKARKTYFRSGKNLQALDLVERAAFFVTLQDDEEG----------- 425

  Fly   367 PTVHRAGDRDETN----MAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAV 427
                 ....|..|    ....::||     ...:|||||:...|:..:|..||..|||.::...|
Frog   426 -----LRTEDPVNSLDAYGKSLLHG-----KCYDRWFDKSFTFIVFKNGKIGLNAEHSWADAPIV 480

  Fly   428 VQLLEKI---------YKKIEEHPDEDN--GLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKC 481
            ..:.|.:         |.      :|.|  |....:||.|:||:|.:..:.| ...|:|.:|.:.
Frog   481 GHMWEFVLATDCFQLGYN------EEGNCKGQVDSNLPVPQRLQWDISEECQ-EVIQSSLAVAQA 538

  Fly   482 I-DDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDC 545
            : ||:||:.:.::.:||..||.|:.|||.:||:|||||||:..|:...|||::.||.|..||.:.
Frog   539 LADDVDFHTFPFKEFGKGLIKKCRTSPDAFIQIALQLAHYRDKGKFCLTYEASMTRLFREGRTET 603

  Fly   546 IRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVK 610
            :|:.:.|:.::.|||......|          ||..|             |||.|..:...:...
Frog   604 VRSCTVESSQFVKAMMNPSQTN----------EERLK-------------LFRLAAEKHQMLYRH 645

  Fly   611 NILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQ-----------------VA 658
            .:.|.|||..|..|...| :..|......|:   ::|:.:.|||||                 |:
Frog   646 AMTGGGIDRHLFCLYVVS-KYLGVDSPFLKE---VLSEPWRLSTSQTPIQQVELFDLVNHPEYVS 706

  Fly   659 CSTDSFMGYGPVTPRGYGCSYNPHPEQIV-FCVSAFYSCEDTSASRYAKSLQDSLDIMRDLL 719
            |..    |:|||...|||.||....|.:: |.:|:.:|..:|.:.|:.|.:|.:|   ||:|
Frog   707 CGG----GFGPVADDGYGVSYIIVGENLINFHISSKFSSHETDSHRFGKHIQGAL---RDIL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	186/684 (27%)
cpt1al	NP_001107300.1	CPT_N	1..46	CDD:293093
cpt1al	NP_001107300.1	Carn_acyltransf	171..760	CDD:279140	187/686 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010