DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc91C and NSP1

DIOPT Version :9

Sequence 1:	NP_650744.1	Gene:	Muc91C / 42246	FlyBaseID:	FBgn0038642	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_012494.3	Gene:	NSP1 / 853409	SGDID:	S000003577	Length:	823	Species:	Saccharomyces cerevisiae

Alignment Length:	739	Identity:	163/739 - (22%)
Similarity:	275/739 - (37%)	Gaps:	175/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 SYGPPPQAKKPHHRRPSSSYGAPRPAPPSQSYGAPPSASYGPPKSAPPSQSYGAPAPPSSKYGPP 273
            ::..|.|.|.|.                  |:|...:.|....:::  |...||.....|.:|..
Yeast     2 NFNTPQQNKTPF------------------SFGTANNNSNTTNQNS--STGAGAFGTGQSTFGFN 46

  Fly   274 KSAPSSSYGAPRPAAP--------SSSYGAPAPPSSSYGAPAAPSSSYGAPAAPSSSYGAPAAPS 330
            .|||:::..|.....|        ::::|...|.|:.:|:..:.::::|:.:|.:|.:|:.:|..
Yeast    47 NSAPNNTNNANSSITPAFGSNNTGNTAFGNSNPTSNVFGSNNSTTNTFGSNSAGTSLFGSSSAQQ 111

  Fly   331 SSYGAPAPPSKSYGAPA----PPSSSYGAPAAPSKSYGA--PAPPSSS---------YGAPA--- 377
            :.....| ...::|:.:    ..:|:...||....::|.  ...|||:         :||.|
Yeast   112 TKSNGTA-GGNTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGNANTSNNLFGATANAN 175

  Fly   378 PPSSSYGAPA-------PPSPSYGAPAPPSKSYGAPAPPSS-SYGAPAAPSKSYGAPAPPSSSYG 434
            .|:.|:||..       |..|::...:.......|.||.:. |:|:....:|:....|.||.|:|
Yeast   176 KPAFSFGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFSFGSQLGGNKTVNEAAKPSLSFG 240

  Fly   435 APAPPSSSYGAPSAPSSSYGPPKPAPAPPSSSYGAPPQAPVSSYLPPASRPSK-----PSSSYGA 494
                 |.|.||..|.:|...|....||.|:.|:|.            |:..:|     ||.|:||
Yeast   241 -----SGSAGANPAGASQPEPTTNEPAKPALSFGT------------ATSDNKTTNTTPSFSFGA 288

  Fly   495 PSVSSFVPLPSAPSTNYGA-PSKTQSLGSSGYSSGPSSSYEAPVAPPSSSYGAPSSSFQPISPPS 558
            .|..:.....|.|:.::|| |.:.:...||               .|:.|:||.|:..:
Yeast   289 KSDENKAGATSKPAFSFGAKPEEKKDDNSS---------------KPAFSFGAKSNEDK------ 332

  Fly   559 SSYGAPSSGSGSSSGSFSAAPSSLYSAPSKGSSGGSFQSAPSSSYSAPSASANSGGSYPSAPSSS 623
                  ..|:...:.||.|.|                              |....:..|.|:.|
Yeast   333 ------QDGTAKPAFSFGAKP------------------------------AEKNNNETSKPAFS 361

  Fly   624 YSAPSSSSSSGGPYASAPSSSYSA-PSSGSNSGGPYPAAPSSSYSAPSASANSGGSYPSAPSSSY 687
            :.|.|.....|.  ||.|:.|:.| |.....|.   .:.|:.|:.|.........|  |.|:.|:
Yeast   362 FGAKSDEKKDGD--ASKPAFSFGAKPDENKASA---TSKPAFSFGAKPEEKKDDNS--SKPAFSF 419

  Fly   688 SAPSPGSNSGGPYPAAPSSSYSAPSPSANSGGPYASAPSSSYSAPSSSSNSGGPYAAAPSSSYSA 752
            .|.|......|  .|.|:.|:.|.....|:.  ..|.|:.|:.|.|.....|.  |:.|:.|:.|
Yeast   420 GAKSNEDKQDG--TAKPAFSFGAKPAEKNNN--ETSKPAFSFGAKSDEKKDGD--ASKPAFSFGA 478

  Fly   753 PSSSSSSGGPYPSAPSSSYSAPSSSLSSGGPYPSAPSSSYAAPSPSSNSGGPYPAAPSNSYSAPI 817
            .|.......  .|.|:.|:...|:.....|  .|.|:.|:.             |.|....:..:
Yeast   479 KSDEKKDSD--SSKPAFSFGTKSNEKKDSG--SSKPAFSFG-------------AKPDEKKNDEV 526

  Fly   818 APPSSSYGAPASGPSPSFSAPSS-SYGAPSTGSGSSSFSSSSSSFSGASSSSSAGYPSAPSSSYG 881
            :.|:.|:||.|:....|..:.|: |:|:..||......:.::.||........:...|.|:.::|
Yeast   527 SKPAFSFGAKANEKKESDESKSAFSFGSKPTGKEEGDGAKAAISFGAKPEEQKSSDTSKPAFTFG 591

  Fly   882 A--------PSTGSGHSFSSAPSS 897
            |        ..:.:|.|.:...||
Yeast   592 AQKDNEKKTEESSTGKSTADVKSS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc91C	NP_650744.1	Mucin-like	224..319	CDD:292676	18/102 (18%)
		Mucin-like	327..419	CDD:292676	24/117 (21%)
		Mucin-like	397..516	CDD:292676	36/125 (29%)
NSP1	NP_012494.3	PHA03255	61..>214	CDD:165513	30/153 (20%)
		PTZ00121	<289..>602	CDD:173412	85/399 (21%)
		Nsp1_C	620..731	CDD:398645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I1425
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960