DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and SLC5A6

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens

Alignment Length:	692	Identity:	149/692 - (21%)
Similarity:	243/692 - (35%)	Gaps:	175/692 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NIAGVVSIVLFYLLILVVGI------WAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGG 61
            :|...|..||..:|.|.:|:      |       |..:..|:::|.|.:|......::.||:...
Human    25 SIMDYVVFVLLLVLSLAIGLYHACRGW-------GRHTVGELLMADRKMGCLPVALSLLATFQSA 82

  Fly    62 GYINGTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGLLFL 126
            ..|.|....||..|..:......|.|.|:.....|.....:....:..:.|:..|.:.:
Human    83 VAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTV------ 141

  Fly   127 PALCGE-------VFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVI 184
             .:||.       |.:...:|.|....|:.:...|...||:....:...||..|||.:|.:|||.
Human   142 -RVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVF 205

  Fly   185 QLFCIFIG-----------------LWMCIPFAWSNEHVGSLSDLEVD---WIGHVEPKKHWLYI 229
            |...:|:|                 :|     |.:::| |.:|..|:|   ::.|.    .|
Human   206 QTLVMFLGQLAVIIVGSAKVGGLGRVW-----AVASQH-GRISGFELDPDPFVRHT----FW--- 257

  Fly   230 DYGLLLVFGGIPW--------QVYFQRVLSSKTAGRAQLLSYVA--------AAGCILMAIPPVL 278
                .|.|||:..        |...||.|||:|...|.|..|..        ..||        |
Human   258 ----TLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGC--------L 310

  Fly   279 IGAIAKATPWNETDYKGPYPLTVDETSMILPMVLQYLTPDFVSFFGL----GAVSAAVMSSADSS 339
            ||.:..|       |...||:::.:........:.|...|.:.  ||    |...|.:.|.:.|:
Human   311 IGLVMFA-------YYQEYPMSIQQAQAAPDQFVLYFVMDLLK--GLPGLPGLFIACLFSGSLST 366

  Fly   340 VLSAASMFARNVYKLIFR---QKASEMEIIWVMRVAIIVVGILATIMAL----------TIPSIY 391
            :.||.:..|....:.:.|   .:.||...|.:.|......|:|...||.          ...||:
Human   367 ISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIF 431

  Fly   392 G------LWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLSGGEAILGLAPLIK 450
            |      |...|..:.:....|...:|          |.|:..::|..|         |:..::.
Human   432 GMVGGPLLGLFCLGMFFPCANPPGAVV----------GLLAGLVMAFWI---------GIGSIVT 477

  Fly   451 YPGYDEETKEQMFPFRTMAMLLSLVTLISVSWWTKMMFESGKLPPSYDYFRCVVNIPEDVQRVGD 515
            ..|      ..|.|..:.....||.|.::|:..|.:|       |...:.:     |..:||...
Human   478 SMG------SSMPPSPSNGSSFSLPTNLTVATVTTLM-------PLTTFSK-----PTGLQRFYS 524

  Fly   516 PS----ESGEQLSVMAGPLARSYGAATMAGKDERNGRINPAL-ESDDDLPVAEARRINQETAQAQ 575
            .|    .:....:|:...|..|.....|.|:......|.|.| :....||::..:|::   .::.
Human   525 LSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLH---CRSY 586

  Fly   576 VKKMLDNATGV---KPSGGGGGHLQSQSGMAMPTAEQDNTAF 614
            .:..||  ||:   ||..|..|..:.:..||:     |.||:
Human   587 GQDHLD--TGLFPEKPRNGVLGDSRDKEAMAL-----DGTAY 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	116/545 (21%)
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	128/609 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810