DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and Slc5a7

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_445973.2	Gene:	Slc5a7 / 85426	RGDID:	69270	Length:	580	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	305/517 - (58%)
Similarity:	385/517 - (74%)	Gaps:	15/517 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NIAGVVSIVLFYLLILVVGIWAGRK-KQSGNDSE--EEVMLAGRSIGLFVGIFTMTATWVGGGYI 64
            ::.|:|:|:||||||.:|||||..| |.|||..|  |.:::.||.|||.||.|||||||||||||
  Rat     4 HVEGLVAIILFYLLIFLVGIWAAWKTKNSGNAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYI 68

  Fly    65 NGTAEAIY--TSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGLLFLP 127
            ||||||:|  ..||.|.|||.||:|||:.||:|||.|||.:||:|||||.|..:|:|||||||:|
  Rat    69 NGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIP 133

  Fly   128 ALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIG 192
            ||.||:||||.|.:|||||:|||||:|...|||:|:.|||.|||.|||||||||||:||||||||
  Rat   134 ALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIG 198

  Fly   193 LWMCIPFAWSNEHVGSL------SDLEVDWIGHVEPKKHWLYIDYGLLLVFGGIPWQVYFQRVLS 251
            ||:.:|||.|:..|..:      :..:..|:|.:|..:.:.::|..|||:.||||||.|||||||
  Rat   199 LWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESIEVYTWLDNFLLLMLGGIPWQAYFQRVLS 263

  Fly   252 SKTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPYPLTVDETSMILPMVLQYLT 316
            |.:|..||:||::||.||::||:|.:.||||..:|.||:|.|..|.|.|.:|..||||:|||||.
  Rat   264 SSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGFPDPKTKEEADMILPIVLQYLC 328

  Fly   317 PDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILAT 381
            |.::|||||||||||||||||||:|||:||||||:|:|.|||.||:.||:||||:.:.|.|..||
  Rat   329 PVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASAT 393

  Fly   382 IMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLSGGEAILGLA 446
            .|||...::||||.:.|||||:|:|||||.|: |.|..||||:::.||..|.:|::|||..|.|.
  Rat   394 AMALLTKTVYGLWYLSSDLVYIIIFPQLLCVL-FIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQ 457

  Fly   447 PLIKYPGYDEETK---EQMFPFRTMAMLLSLVTLISVSWWTKMMFESGKLPPSYDYFRCVVN 505
            |||.||||..:..   .|.|||:|::|:.|..|.|.||:..|.:||||.|||..|.|..||:
  Rat   458 PLIFYPGYYPDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLPPKLDIFDAVVS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	290/487 (60%)
Slc5a7	NP_445973.2	SLC5sbd_CHT	8..495	CDD:271368	290/487 (60%)
Slc5a7	NP_445973.2	Mediates interaction with SEC14L1. /evidence=ECO:0000269\|PubMed:17092608	502..580		11/18 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	497	1.000	Domainoid score	I346
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32516
Inparanoid	1	1.050	596	1.000	Inparanoid score	I927
OMA	1	1.010	-	-		QHG62377
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004760
OrthoInspector	1	1.000	-	-		oto96593
orthoMCL	1	0.900	-	-		OOG6_104374
Panther	1	1.100	-	-	LDO	PTHR45897
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3349
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830