DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and SLC5A7

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001291934.1	Gene:	SLC5A7 / 60482	HGNCID:	14025	Length:	580	Species:	Homo sapiens

Alignment Length:	516	Identity:	302/516 - (58%)
Similarity:	386/516 - (74%)	Gaps:	15/516 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NIAGVVSIVLFYLLILVVGIWAG-RKKQSGNDSE--EEVMLAGRSIGLFVGIFTMTATWVGGGYI 64
            ::.|:::|::||||||:|||||. |.|.||:..|  |.:::.||.|||.||.|||||||||||||
Human     4 HVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYI 68

  Fly    65 NGTAEAIYTS--GLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGLLFLP 127
            ||||||:|..  ||.|.|||.||:|||:.||:|||.|||.:||:|||||.|..:|:|||||||:|
Human    69 NGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIP 133

  Fly   128 ALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIG 192
            ||.||:||||.|.:|||||:|||||:|...|||:|:.||..|||.|||||||||||:||||||:|
Human   134 ALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVG 198

  Fly   193 LWMCIPFAWSNEHVGSL------SDLEVDWIGHVEPKKHWLYIDYGLLLVFGGIPWQVYFQRVLS 251
            ||:.:|||.|:..|..:      :..:..|:|.|:..:.:.::|..|||:.||||||.|||||||
Human   199 LWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLS 263

  Fly   252 SKTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPYPLTVDETSMILPMVLQYLT 316
            |.:|..||:||::||.||::||||.:|||||..:|.||:|.|..|.|.|.:|..||||:|||||.
Human   264 SSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLC 328

  Fly   317 PDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILAT 381
            |.::|||||||||||||||||||:|||:||||||:|:|.|||.||:.||:||||:.:.|.|..||
Human   329 PVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASAT 393

  Fly   382 IMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLSGGEAILGLA 446
            .|||...::||||.:.|||||:::|||||.|: |.|..||||:::.|:..|.:|::|||..|.|.
Human   394 AMALLTKTVYGLWYLSSDLVYIVIFPQLLCVL-FVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQ 457

  Fly   447 PLIKYPGY---DEETKEQMFPFRTMAMLLSLVTLISVSWWTKMMFESGKLPPSYDYFRCVV 504
            |||.||||   |.....|.|||:|:||:.|.:|.|.:|:..|.:||||.|||..|.|..||
Human   458 PLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVV 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	288/487 (59%)
SLC5A7	NP_001291934.1	SLC5sbd_CHT	8..495	CDD:271368	288/487 (59%)
SLC5A7	NP_001291934.1	Mediates interaction with SEC14L1. /evidence=ECO:0000250\|UniProtKB:Q9JMD7	502..580		11/17 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	498	1.000	Domainoid score	I350
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32516
Inparanoid	1	1.050	598	1.000	Inparanoid score	I961
Isobase	1	0.950	-	0.969724	Normalized mean entropy	S2487
OMA	1	1.010	-	-		QHG62377
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004760
OrthoInspector	1	1.000	-	-		oto89468
orthoMCL	1	0.900	-	-		OOG6_104374
Panther	1	1.100	-	-	LDO	PTHR45897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2785
SonicParanoid	1	1.000	-	-		X3349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810