DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and slc5a11

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001007301.1	Gene:	slc5a11 / 492334	ZFINID:	ZDB-GENE-041114-9	Length:	668	Species:	Danio rerio

Alignment Length:	603	Identity:	140/603 - (23%)
Similarity:	252/603 - (41%)	Gaps:	147/603 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVSIVLFYLLILVVGIWA-GRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYI-----N 65
            :|.:|:::||:|.||:|: .:.|:|..|.   ..|||:::..:....::.|:.||.|:.     :
Zfish    29 IVVLVIYFLLVLAVGLWSMWKTKRSTVDG---YFLAGKNMTWWPVGASLFASNVGSGHFIGLAGS 90

  Fly    66 GTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYI-----TMLDPLQDSF-GERMGGLL 124
            |.|..|......|    .|..:.||.|.:|.  |:    ||     ||.:.|:..| |:|:...|
Zfish    91 GAAAGIGAVAYEW----NGMLMVLVMGWLFL--PI----YIASRVTTMPEYLKKRFGGKRIQLFL 145

  Fly   125 FLPALCGEVFWAAGILAALGAT-LSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFC 188
            .:..|...:|....:....||. :...:..:...:|:|...|...||:.|||.:|.|||.:|...
Zfish   146 CVLYLFIYIFTKISVDMYAGAVFIQQALQWNIYLAVVLLLGITALYTIAGGLAAVIYTDAVQTII 210

  Fly   189 IFIGLWMCIPFAWS---------NEHVGSLSDLEV---------DWIGHVEPKKHWLYIDY---G 232
            :.||..:.:.|:::         :::..::..:.|         |...|:  .:|.:..|.   |
Zfish   211 MVIGALILMGFSFAEVGGFEAVLDKYPQAIPSIRVPNTTCGIPRDDAFHI--FRHPVTSDLPWPG 273

  Fly   233 LLLVFGGIP----W---QVYFQRVLSSK----TAGRAQLLSYVAAAGCILMAIPPVLIGAIAKAT 286
            ::|.. .||    |   ||..||.|::|    ..|.:.|.:|:......:|.||    |.|::..
Zfish   274 VILGM-SIPSMWYWCSDQVIVQRSLAAKNILHAKGGSLLAAYIKVLPFFMMVIP----GMISRIL 333

  Fly   287 PWNETDYKGP-----------------YPLTVDETSMILPMVLQYLTPDFVSFFGLGAVSAAVMS 334
            ..:|.....|                 |...|.|   :||..|:.|.        :..:.||:||
Zfish   334 YPDEVGCGDPEVCKEVCGNSVGCSDIAYAKLVME---LLPAGLRGLM--------MAVMLAALMS 387

  Fly   335 SADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILATIMALTIPSIY----GLWS 395
            |..|...|::::|..::::.| |..|||.|::.|.||.::|   |..:..|.||.:.    |...
Zfish   388 SLTSIFNSSSTIFTMDLWRNI-RHTASEWELMIVGRVFVLV---LVVVSVLWIPLVQASQGGQLF 448

  Fly   396 MCSDLVYVILFPQLLMVV---HFKKHCNTYGSLSAYIVALAIRLSGGEAILGLAPLIK---YPG- 453
            :....:.:.|.|.:.::.   .|.|..|..|:....:|.:|:         |...:|.   ||.
Zfish   449 IYIQSISMYLQPPITVIFVAGCFWKRTNEKGAFWGLMVGMAV---------GCTRMILDFIYPTP 504

  Fly   454 --YDEETKEQMFP---FRTMAMLLSLVTLISV------------------SWWTKM--MFESGKL 493
              |:.:|:..:..   |...:::|:::||:.|                  :|:|:.  :.||.::
Zfish   505 QCYESDTRPDIIKYVHFLYFSIILTILTLVVVVCVSLATEKPKPEQISRLTWYTRFDAVIESEEV 569

  Fly   494 PPSYDYFRCVVNIPEDVQ 511
            ..|..|     .|..|::
Zfish   570 VSSELY-----TIDNDIK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	132/569 (23%)
slc5a11	NP_001007301.1	SLC5sbd_SGLT6	28..668	CDD:271381	140/603 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810