DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and slc5a2

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_998091.1	Gene:	slc5a2 / 405862	ZFINID:	ZDB-GENE-040426-2498	Length:	662	Species:	Danio rerio

Alignment Length:	591	Identity:	148/591 - (25%)
Similarity:	241/591 - (40%)	Gaps:	154/591 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGY---I 64
            |.|.:..|::::|:::.||||:..:...|  :.....||||::..:....::.|:.:|.|:   :
Zfish    13 NAADISVIIIYFLVVIAVGIWSTFRTNRG--TVGGYFLAGRTMVWWPVGTSLFASNIGSGHFVGL 75

  Fly    65 NGTAEA--IYTSGLVWCQAPFGYALSLVFGGIFFANPM-RKQGYITMLDPLQDSFGERMGGL--- 123
            .|||.|  |...|..| .|.|   :.|:.|.:|.  |: ...|.|||...|:..||.....|
Zfish    76 AGTAAASGIAVGGFEW-NALF---IVLLLGWVFV--PVYLTAGVITMPQYLKKRFGGSRISLYLS 134

  Fly   124 ---LFL--------PALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYS 177
               |||        ....|.||    |..|||..:.|        :||...||...||:.|||.:
Zfish   135 IISLFLYIFTKISVDMFSGAVF----IQQALGWNIYV--------AVIALLCITALYTVTGGLAA 187

  Fly   178 VAYTDVIQLFCIFIGLWMCIPFAWSNEHVG------------------SLSDLEVDWIGHV---- 220
            :.|||.:|.|.|..|.::.:.|::  ..||                  ||:..|.:...|.
Zfish   188 LMYTDTVQTFVIIAGAFVLMGFSF--YEVGGYSALLEKYNSSLPSQTLSLNPNEYNISQHCYMPR 250

  Fly   221 EPKKH-----------WLYIDYGLLLVFGGIPW---QVYFQRVLSSKTAGRAQLLSYVAAAGCI- 270
            |...|           |..:.:|:.:: |...|   ||..||.|::::      |::| .||||
Zfish   251 EDAFHLLRDPTTGDLPWPGVIFGIAII-GSWYWCTDQVIVQRCLAARS------LTHV-KAGCIL 307

  Fly   271 ----------LMAIPPVL--------IGAIAKATPWNE---TDYKGPYPLTVDETSMILPMVLQY 314
                      ||..|.::        :|.:.|:. .|:   |:        |..:::..|.::..
Zfish   308 CGYLKLLPMFLMVFPGMISRVLYPDDVGCVEKSV-CNKVCGTE--------VGCSNIAYPKLVVS 363

  Fly   315 LTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAII-VVGI 378
            :.|..:....|..:.||:|||..|...|::::|..:::..| |.:|.:.|::.|.||.|: :|||
Zfish   364 VMPTGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRI-RPQARDKELMVVGRVWILCIVGI 427

  Fly   379 ----LATIMALTIPSIYG-LWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLSG 438
                :..:.|.....::. :.|:.|.|...|.....|.:  |.|..|..|:...        |.|
Zfish   428 STCWIPVVQAAQSGQLFDYIQSVTSYLAPPIAAVFFLAI--FVKRVNESGAFWG--------LMG 482

  Fly   439 GEAILGLAPLIKYP----GYDEETKEQMFP-------FRTMAMLLSLVTLISVSWWTKMMFESGK 492
            | .::||..::  |    |.....|....|       :...|:||...|.|.|      :|.|..
Zfish   483 G-LVMGLCRMV--PEFVFGSGSCLKPSNCPKVICGVHYLYFAILLFFCTAILV------LFVSYN 538

  Fly   493 LPPSYD 498
            .||..|
Zfish   539 TPPIKD 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	140/568 (25%)
slc5a2	NP_998091.1	SLC5sbd_SGLT2	15..662	CDD:212056	147/589 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840