DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and slc5a12

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	546	Identity:	116/546 - (21%)
Similarity:	183/546 - (33%)	Gaps:	179/546 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLFYLLILV---VGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTAEAIY 72
            |:|..|.:|   :|::...|:::...| :|.::.||.:.......::||:::....:.|....:|
Zfish    13 VVFACLFVVSSGIGVFFAIKERNKAPS-KEFLVGGRQMSCGPVALSLTASFMSAVTVIGAPADVY 76

  Fly    73 TSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGLLFLPALCGEVFWAA 137
            ..|..:  ..||.|.:.|   :||.                        ..||||     ||:.:
Zfish    77 RFGASY--VIFGVAYTFV---VFFT------------------------AELFLP-----VFYRS 107

  Fly   138 GI-------------LAALGATLSVIID---------------------MDHRTSVILSSCIAIF 168
            ||             |..:.|||..||.                     .|...|:..:..:..|
Zfish   108 GITSTYEYLELRFCKLVRVAATLIYIIQTILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTF 172

  Fly   169 YTLFGGLYSVAYTDVIQLFCIFIGLWMC----------IPFAWSNEHVGS-LSDLEVDWIGHVEP 222
            |...|||.:|.:||..|:..:.:|....          |...||....|. |...:.|    |.|
Zfish   173 YCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSSRAGGIENVWSTSRTGGRLQVFDFD----VSP 233

  Fly   223 -KKHWLYIDYGLLLVFGGIPW-------QVYFQRVLSSKTAGRAQLLSYVAAAGCILMAIPPVLI 279
             ::|    .:..|.|.|...|       |...||.:|.||.|.|:...|:...|..::....|:.
Zfish   234 LRRH----TFWTLSVGGTFTWLGIYGVNQSTIQRCISCKTEGHARWALYLNLLGLWIILFCAVVS 294

  Fly   280 GAI-----AKATPWNETDYKGPYPLTVDETSMILPMVLQYLTPDFV-----SFFGL-GAVSAAVM 333
            |.|     :...||:......|                ..|.|.||     :|.|| |...|...
Zfish   295 GLIMYSYYSHCDPWSSGLISAP----------------DQLMPYFVMEILGAFPGLPGLFVACAF 343

  Fly   334 SSADSSVLSAASMFARNVYKLIFRQ---KASEMEIIWVMRVAIIVVGILATIMALTIPSIYGLWS 395
            |...|:|.::.:..|..:|:....|   ..|.....|:.:...:..|:..|.||:....:.|
Zfish   344 SGTLSTVAASINALATVMYEDFVSQCFPDLSNRAASWISKALCVAFGVACTTMAVAASYMGG--- 405

  Fly   396 MCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLSG--GEAILGLAPLIKYPGYDEET 458
                                             ||..|:.:.|  |..:|||..|    |.
Zfish   406 ---------------------------------IVQAALSIHGMCGGPVLGLFSL----GI---- 429

  Fly   459 KEQMFPFRTM-AMLLSLVTLISVSWW 483
               :|||..: ..:..|:..||:|:|
Zfish   430 ---LFPFTNLKGAVGGLIVGISLSFW 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	114/542 (21%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	116/546 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840