DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and Slc5a11

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_666310.1	Gene:	Slc5a11 / 233836	MGIID:	1919316	Length:	673	Species:	Mus musculus

Alignment Length:	564	Identity:	139/564 - (24%)
Similarity:	243/564 - (43%)	Gaps:	129/564 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGVVSIVLFYLLILVVGIWAG-RKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTA 68
            |.:..:||::|.:|.||:|:. |.|:   |:.:...|||..:..:....::.|:.||.|:..|.|
Mouse    27 ADIAVLVLYFLFVLAVGLWSTVRTKR---DTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLA 88

  Fly    69 EAIYTSGLVWCQAPFGYALSLVFGGIFFA---NPMRKQGYI-TMLDPLQDSF-GERMGGLLFLPA 128
            .:....|:    :...|.|:.:|..:..|   .|:...|.: ||.:.|:..| |.|:...|.:..
Mouse    89 GSGAAVGI----SVAAYELNGLFSVLMLAWVFLPIYIAGQVTTMPEYLRRRFGGNRISITLAVLY 149

  Fly   129 LCGEVFWAAGILAALGAT-LSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIG 192
            |...:|....:....||. :...:.:|...:::....|...||:.|||.:|.|||.:|...:.||
Mouse   150 LFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITALYTVAGGLAAVIYTDALQTVIMLIG 214

  Fly   193 LWMCIPFAWSNEHVGSLSDLEVDWIGHVE-----------PKKHWLYIDYGLL--------LVFG 238
            .::.:.::::  .||.:..|:..:...:.           |::...:|....|        ::||
Mouse   215 AFILMGYSFA--AVGGMEGLKDQYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGILFG 277

  Fly   239 -GIP----W---QVYFQRVLSSKTAGRAQ----LLSYVAAAGCILMAIPPVLIGAIAK------- 284
             .||    |   ||..||.|::|....|:    :.:|:......||..|    |.:::
Mouse   278 MSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVFP----GMVSRVLFPDQV 338

  Fly   285 ------------ATPWNETDYKGPYPLTVDETSMILPMVLQYLTPDFVSFFGLGAVSAAVMSSAD 337
                        :.|...:|.  .||..|.|   :||..|:.|.        :..:.||:|||..
Mouse   339 ACAHPDICQRVCSNPSGCSDI--AYPKLVLE---LLPTGLRGLM--------MAVMVAALMSSLT 390

  Fly   338 SSVLSAASMFARNVYKLIFRQKASEMEIIWVMRV---AIIVVGILATIMALTIPSIYGLWSMCSD 399
            |...||:::|..:::..| |.:|||.|::.|.|:   |:::|.|      |.||.:..  |....
Mouse   391 SIFNSASTIFTMDLWNHI-RPRASERELMIVGRIFVFALVLVSI------LWIPIVQA--SQGGQ 446

  Fly   400 L-VYV-----ILFPQLLMVV---HFKKHCNTYGSLSAYIVALAIRLSGGEAILGLAPLI-----K 450
            | :|:     .|.|.:.||.   .|.|..|..|:.|..|:.|         :|||..||     .
Mouse   447 LFIYIQSISSYLQPPVAMVFIMGCFWKRTNEKGAFSGLILGL---------LLGLVRLILDFVYA 502

  Fly   451 YPGYDEE------TKEQMFPFRTMAMLLS---LVTLISVSWWTK 485
            .|..|:.      .|:..:.:  .:|:||   |:|:::|||:|:
Mouse   503 QPRCDQPDDRPAVVKDVHYLY--FSMILSFTTLITVVTVSWFTE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	134/556 (24%)
Slc5a11	NP_666310.1	SLC5-6-like_sbd	28..673	CDD:382020	138/563 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810