Protein Alignment ChT and Slc5a8

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_663398.2
• Gene: Slc5a8 / 216225
• MGIID: 2384916
• Length: 611
• Species: Mus musculus
• Alignment Length: 550
• Identity: 121/550 - (22%)
• Similarity: 222/550 - (40%)
• Gaps: 95/550 - (17%)

  Fly    11 VLFYLLILV---VGIW---AGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTAE 69
            |:|..::|:   :||:   ||    .|..:.::.::.|||:.......::||:::....:.||..
Mouse    16 VVFAGMLLISAAIGIYYAFAG----GGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPA 76

  Fly    70 AIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERM---GGLLFLPALCG 131
            .:|..|.::......|...:|.....|.....:.|..:..:.|:..|...:   |.:||   :..
Mouse    77 EVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILF---IVQ 138

  Fly   132 EVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIGLWMC 196
            .:.:...::.|....|:.:...|...:|:.:..:..||...|||.:|.:|||.|:..:..|....
Mouse   139 TILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASV 203

  Fly   197 IPFAWSNEHVGSLSDLEVD---------WIGHVEP-KKHWLYIDYGLLLVFGG-IPW-------Q 243
            |..|...:|  .::.:..|         |.....| ::|..:     .:|.|| ..|       |
Mouse   204 IIQASITQH--GINKILSDAFNGGRLNFWNFDPNPLQRHTFW-----TIVIGGTFTWTTIYGVNQ 261

  Fly   244 VYFQRVLSSKTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPYPLTVDETSMIL 308
            ...||.:|.|:...|:|..||...|..::....:..| :|..:.:.|.|     |.|..:.|.|
Mouse   262 SQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCG-LALYSRYRECD-----PWTSKKVSAI- 319

  Fly   309 PMVLQYLTPDFVSFF----GLGAVSA--AVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIW 367
            ..::.||..|.:..:    ||....|  ..:|:..||:.:.|::...::.|..|: ..||..:.|
Mouse   320 DQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFK-SLSEKSLSW 383

  Fly   368 VMRVAIIVVGILATIMALTIPSIYGLWSMCSDLVYVILFPQLL------MVVHFKKHCNTYGSLS 426
            :.:...::.|.|...|| .:.|:.|.....:..::.::...||      ::|.|   .|:.|:|:
Mouse   384 ISQGMSVLYGALCIGMA-ALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPF---ANSIGALT 444

  Fly   427 AYIVALAIRLSGG----------EAILGLAPL------IKYPGYDEETKEQMFPFRTMAMLLSLV 475
            ..:...||.|..|          |..|.| ||      |.:.|.|..:..:| ||.|.|..:...
Mouse   445 GLLAGFAISLWVGIGAQLYPPLPERTLPL-PLETYGCNITHNGSDWMSTTEM-PFSTSAFQIHNA 507

  Fly   476 --TLISVSWWTKMMFESGKLPPSYDYFRCV 503
              |.:..:|::.          ||.||..:
Mouse   508 ERTPLMDNWYSL----------SYLYFSTI 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	116/526 (22%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	121/549 (22%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q8N695	609..611