DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and Slc5a8

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus

Alignment Length:	550	Identity:	121/550 - (22%)
Similarity:	222/550 - (40%)	Gaps:	95/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLFYLLILV---VGIW---AGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTAE 69
            |:|..::|:   :||:   ||    .|..:.::.::.|||:.......::||:::....:.||..
Mouse    16 VVFAGMLLISAAIGIYYAFAG----GGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPA 76

  Fly    70 AIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERM---GGLLFLPALCG 131
            .:|..|.::......|...:|.....|.....:.|..:..:.|:..|...:   |.:||   :..
Mouse    77 EVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILF---IVQ 138

  Fly   132 EVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIGLWMC 196
            .:.:...::.|....|:.:...|...:|:.:..:..||...|||.:|.:|||.|:..:..|....
Mouse   139 TILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASV 203

  Fly   197 IPFAWSNEHVGSLSDLEVD---------WIGHVEP-KKHWLYIDYGLLLVFGG-IPW-------Q 243
            |..|...:|  .::.:..|         |.....| ::|..:     .:|.|| ..|       |
Mouse   204 IIQASITQH--GINKILSDAFNGGRLNFWNFDPNPLQRHTFW-----TIVIGGTFTWTTIYGVNQ 261

  Fly   244 VYFQRVLSSKTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPYPLTVDETSMIL 308
            ...||.:|.|:...|:|..||...|..::....:..| :|..:.:.|.|     |.|..:.|.|
Mouse   262 SQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCG-LALYSRYRECD-----PWTSKKVSAI- 319

  Fly   309 PMVLQYLTPDFVSFF----GLGAVSA--AVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIW 367
            ..::.||..|.:..:    ||....|  ..:|:..||:.:.|::...::.|..|: ..||..:.|
Mouse   320 DQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFK-SLSEKSLSW 383

  Fly   368 VMRVAIIVVGILATIMALTIPSIYGLWSMCSDLVYVILFPQLL------MVVHFKKHCNTYGSLS 426
            :.:...::.|.|...|| .:.|:.|.....:..::.::...||      ::|.|   .|:.|:|:
Mouse   384 ISQGMSVLYGALCIGMA-ALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPF---ANSIGALT 444

  Fly   427 AYIVALAIRLSGG----------EAILGLAPL------IKYPGYDEETKEQMFPFRTMAMLLSLV 475
            ..:...||.|..|          |..|.| ||      |.:.|.|..:..:| ||.|.|..:...
Mouse   445 GLLAGFAISLWVGIGAQLYPPLPERTLPL-PLETYGCNITHNGSDWMSTTEM-PFSTSAFQIHNA 507

  Fly   476 --TLISVSWWTKMMFESGKLPPSYDYFRCV 503
              |.:..:|::.          ||.||..:
Mouse   508 ERTPLMDNWYSL----------SYLYFSTI 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	116/526 (22%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	121/549 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740