DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and cho-1

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_502539.1	Gene:	cho-1 / 178274	WormBaseID:	WBGene00000501	Length:	576	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	328/547 - (59%)
Similarity:	401/547 - (73%)	Gaps:	26/547 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSE-------EEVMLAGRSIGLFVGIFTMTATW 58
            |.::.|:|:||.||:||||||||||||.:|..:.|       ||||||||:||..||||||||||
Worm     1 MADLLGIVAIVFFYVLILVVGIWAGRKSKSSKELESEAGAATEEVMLAGRNIGTLVGIFTMTATW 65

  Fly    59 VGGGYINGTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGL 123
            |||.||||||||:|..||:.||||.|||:|||.||:.||..||::||||||||.|..:|:|:|||
Worm    66 VGGAYINGTAEALYNGGLLGCQAPVGYAISLVMGGLLFAKKMREEGYITMLDPFQHKYGQRIGGL 130

  Fly   124 LFLPALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFC 188
            :::|||.||.||.|.||:|||||||||:.:|...||.||:|||:|||..||.|:||||||:||||
Worm   131 MYVPALLGETFWTAAILSALGATLSVILGIDMNASVTLSACIAVFYTFTGGYYAVAYTDVVQLFC 195

  Fly   189 IFIGLWMCIPFAWSNEHVGSLSDLEVDWIGHVEP-KKHWLYIDYGLLLVFGGIPWQVYFQRVLSS 252
            ||:|||:|:|.|..::....:|....||||.:.. |:..|:||..||||||||||||||||||||
Worm   196 IFVGLWVCVPAAMVHDGAKDISRNAGDWIGEIGGFKETSLWIDCMLLLVFGGIPWQVYFQRVLSS 260

  Fly   253 KTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPY-------PLTVDETSMILPM 310
            |||..||.||:||..|||||||||.||||||:.|.|..||| .|:       .:..|:.:|::|:
Worm   261 KTAHGAQTLSFVAGVGCILMAIPPALIGAIARNTDWRMTDY-SPWNNGTKVESIPPDKRNMVVPL 324

  Fly   311 VLQYLTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIV 375
            |.|||||.:|:|.|||||||||||||||||||||||||.|::||..|..|||.|:|.|||:|||.
Worm   325 VFQYLTPRWVAFIGLGAVSAAVMSSADSSVLSAASMFAHNIWKLTIRPHASEKEVIIVMRIAIIC 389

  Fly   376 VGILATIMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLSGGE 440
            |||:||||||||.||||||.:|:||||||||||||.||:..: .||||||:.|.|.|.:||.|||
Worm   390 VGIMATIMALTIQSIYGLWYLCADLVYVILFPQLLCVVYMPR-SNTYGSLAGYAVGLVLRLIGGE 453

  Fly   441 AILGLAPLIKYPGYDEETKEQMFPFRTMAMLLSLVTLISVSWWTKMMFESGKLPPSYDYFRCVVN 505
            .::.|.....||.|.:..  |.|||||.|||.|:.|:..||..::.:|:||:|.|.:|...||||
Worm   454 PLVSLPAFFHYPMYTDGV--QYFPFRTTAMLSSMATIYIVSIQSEKLFKSGRLSPEWDVMGCVVN 516

  Fly   506 IPEDVQRVGDPSE-----SGEQLSVMA 527
            ||  :..|..||:     |.|.|::.|
Worm   517 IP--IDHVPLPSDVSFAVSSETLNMKA 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	305/488 (63%)
cho-1	NP_502539.1	SLC5sbd_CHT	7..492	CDD:271368	305/488 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166947
Domainoid	1	1.000	507	1.000	Domainoid score	I165
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32516
Inparanoid	1	1.050	616	1.000	Inparanoid score	I486
Isobase	1	0.950	-	0.969724	Normalized mean entropy	S2487
OMA	1	1.010	-	-		QHG62377
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004760
OrthoInspector	1	1.000	-	-		oto18691
orthoMCL	1	0.900	-	-		OOG6_104374
Panther	1	1.100	-	-	LDO	PTHR45897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2785
SonicParanoid	1	1.000	-	-		X3349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740