Protein Alignment ChT and SLC5A12

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 108/553 - (19%)
• Similarity: 199/553 - (35%)
• Gaps: 124/553 - (22%)

  Fly    11 VLFYLLILV---VGIWAGRKKQSGNDSEEEVMLAGRSIGLF-VGIFTMTATWVGGGYINGTAEAI 71
            |:|..|..:   :|::...|::. ..:..|.::.||.:... ||: ::||:::....:.||...:
Human    12 VVFAALFFISSGIGVFFAIKERK-KATSREFLVGGRQMSFGPVGL-SLTASFMSAVTVLGTPSEV 74

  Fly    72 YTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGLLFLPALCGEVFWA 136
            |..|..:......|...::.....|.....:.|..:..:.||..|.:.:.....:..:...:.:.
Human    75 YRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIYIVQTILYT 139

  Fly   137 AGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIGLWMCIPFAW 201
            ..::.|....|:.:...|...||..:..:..||...|||.:|.:||..|:..:.:|....:  ..
Human   140 GVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVL--IQ 202

  Fly   202 SNEHVGS---------------LSDLEVD-------WIGHVEPKKHWLYIDYGLLLVFGGIPWQV 244
            .:.|.|.               :.|.:||       |...|.....||.| ||:.        |.
Human   203 GSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGI-YGVN--------QS 258

  Fly   245 YFQRVLSSKTAGRAQLLSYVAAAGCILMAIPPVLIGAI-----AKATPWNETDYKGPYPLTVDET 304
            ..||.:|.||...|:|..|....|..::.:..|..|.|     ....||.......|
Human   259 TIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAP-------- 315

  Fly   305 SMILPMVLQYLTPDFVSFFGLGAVSAA-----VMSSADSSVLSAASMFARNVYKLIFRQKASEME 364
            ..::|..:..:   |.:..||..:..|     .:|:..||:.:.|::...:..|..|...:.::.
Human   316 DQLMPYFVMEI---FATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLS 377

  Fly   365 IIWVMRVAIIVVGILATIMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYI 429
             .|:.:...::.|::.|.||:.                                    .|:...:
Human   378 -TWISKGLCLLFGVMCTSMAVA------------------------------------ASVMGGV 405

  Fly   430 VALAIRLSG--GEAILGLAPLIKYPGYDEETKEQMFPF-RTMAMLLSLVTLISVSWWTKM----- 486
            |..::.:.|  |..:|||..|    |.       :||| .....|..|:|.|::|:|..:
Human   406 VQASLSIHGMCGGPMLGLFSL----GI-------VFPFVNWKGALGGLLTGITLSFWVAIGAFIY 459

  Fly   487 ---MFESGKLPPSYDYFRCVVNIPEDVQRVGDP 516
               ..::..||.|.|  :|   |..:|...|.|
Human   460 PAPASKTWPLPLSTD--QC---IKSNVTATGPP 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	97/508 (19%)
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	108/553 (20%)