DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and Slc5a5

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	105/505 - (20%)
Similarity:	194/505 - (38%)	Gaps:	115/505 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LFYLLILV---VGIWAGRKKQSGNDSEEEVMLAGRSIGLF-VGIFTMTATWVGGGYINGT-AEAI 71
            :|..::||   :|:|.|..: .|..|.::....||.:... ||: ::.|:::....:.|. |||.
  Rat    19 VFATMLLVSTGIGLWVGLAR-GGQRSADDFFTGGRQLAAVPVGL-SLAASFMSAVQVLGVPAEAA 81

  Fly    72 -YTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERM---GGLLFLPA---L 129
             |....:|..|  |..|:.:.....|.....:.|..:....|:..|...:   |.|.:|.|   .
  Rat    82 RYGLKFLWMCA--GQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLY 144

  Fly   130 CGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIGLW 194
            .|.|.:|..::      |:.:..:|...|::.:..|...||..||:.:|.:|||.|:..:.:|.|
  Rat   145 TGIVIYAPALI------LNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFW 203

  Fly   195 M--------------CIPFAWSNEHVGSLSDLEVDWIGHVEPKKHWLYIDYGLLLVFGGIPW--- 242
            :              .:..|.::..: :|.|.:.|      |:..:.:..:   :|.|.:.|
  Rat   204 VILARGVILLGGPRNMLSLAQNHSRI-NLMDFDPD------PRSRYTFWTF---IVGGTLVWLSM 258

  Fly   243 ----QVYFQRVLSSKTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPYPLTVDE 303
                |...||.::..|.|:|:|...|...|..|:.......|.:....      ||...||....
  Rat   259 YGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVY------YKDCDPLLTGR 317

  Fly   304 TS---MILPMVLQYLTPDFVSFFG--LGAVSAAVMSSADSSVLSAASMFARNVY----------K 353
            .|   ..:|:::..:..|.....|  |....:..:|:|.:|:.:.|::...::.          |
  Rat   318 ISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRK 382

  Fly   354 LIFRQKASEMEIIWVMRVAIIVVGILA------------TIMALTIPSIYGLWSMCSDLVYVILF 406
            |:|..|.    :.::...|.:.|..|:            |:|.:....:.|.:::      .:|.
  Rat   383 LVFISKG----LSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTL------GMLL 437

  Fly   407 PQLLMVVHFKKHCNTYGSLSAYIVALAIRL---------SGGEAILGLAP 447
            |.          |||.|.||.....||:.|         ..||..:|:.|
  Rat   438 PA----------CNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLP 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	105/505 (21%)
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	105/505 (21%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830