DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and Slc5a10

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_006532041.1	Gene:	Slc5a10 / 109342	MGIID:	1926089	Length:	611	Species:	Mus musculus

Alignment Length:	595	Identity:	130/595 - (21%)
Similarity:	224/595 - (37%)	Gaps:	192/595 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INIAGVVSIVLFYLLILVVGIW----AGRKKQSGNDSEEEVMLAGRSI----------------G 46
            :::..::.|.:::.|.:.||||    |.:...||      ..||||.:                |
Mouse    51 LSVTDIIVISVYFALNVAVGIWSACRANKNTVSG------YFLAGRDMAWWPIGASLFASSEGSG 109

  Fly    47 LFVGIFTMTATWVGGGYINGTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDP 111
            ||||:       .|.|...|.|.|    |..|                         ..:|:.:.
Mouse   110 LFVGL-------AGSGAAGGLAVA----GFEW-------------------------NIVTLPEY 138

  Fly   112 LQDSF-GERMGGLLFLPALCGEVFWAAGILAALGAT-LSVIIDMDHRTSVILSSCIAIFYTLFGG 174
            :|..| |:|:...|.:.:|...||....|....||. :.:.:..:...|.||:..|...||:.||
Mouse   139 IQKRFGGQRIRTYLSVLSLMLSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGG 203

  Fly   175 LYSVAYTDVIQLFCIFIGLWMCIPFAWSNEHVGSLSDLEVDWIGHVEPK--------------KH 225
            |.:|.|||.:|...:.:|..:....|::  .:|....||..:...:..:              .|
Mouse   204 LATVIYTDALQTIIMVVGAVILAVKAFN--QIGGYEQLEAAYAQAIPSRTIPNTTCHLPRADAMH 266

  Fly   226 -----------WLYIDYGLLLVFGGIPW-----QVYFQRVLSSKTAGRAQ----LLSYVAAAGCI 270
                       |..:.:||.::   ..|     ||..||.||::....|:    |.||:......
Mouse   267 MFRDPSTGDLPWTGMTFGLTIM---ATWYWCTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMG 328

  Fly   271 LMAIPPVLIGAIAKATPWNETDYKGP-----------------YPLTVDETSMILPMVLQYLTPD 318
            ||.:|    |.|::....::.....|                 ||..|.|   ::|:.|:.|.
Mouse   329 LMIMP----GMISRVLFPDDVGCVVPSECLRACGAEIGCSNIAYPKLVME---LMPIGLRGLM-- 384

  Fly   319 FVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILATIM 383
                  :..:.||::||..|...|::::|..::::.: |..|.|.|::.|.|:.|:|   |..:.
Mouse   385 ------IAVMMAALLSSLTSIFNSSSTLFTMDIWRQL-RPSAGERELLLVGRLVIVV---LIGVS 439

  Fly   384 ALTIPSIYG---------LWSMCSDLVYVILFPQLLMVVHFKKHCNTYGS---LSAYIVALAIRL 436
            ...||.:.|         :.|:.|.|...:....:|.:  |.:..|..|:   |.|.:|..|:||
Mouse   440 VAWIPVLQGSNSGQLFIYMQSVTSSLAPPVTAIFILGI--FWRRANEQGAFWGLMAGLVVGALRL 502

  Fly   437 SGGEAILGLAPLIKYPGYDEETKEQM----FPFRTM-----AMLLSLVT--------LIS----- 479
                       ::::. |.|....|:    .|.|::     |:.|.|:|        |:|
Mouse   503 -----------VLEFL-YPEPPCGQIDTRPAPLRSLHYLHFAIALFLLTCAVMAAGSLLSPPPQQ 555

  Fly   480 -----VSWWT 484
                 ::|||
Mouse   556 RQIENLTWWT 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	127/585 (22%)
Slc5a10	XP_006532041.1	SLC5-6-like_sbd	52..611	CDD:382020	130/594 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740