DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChT and slc5a7a

DIOPT Version :9

Sequence 1:	NP_650743.1	Gene:	ChT / 42245	FlyBaseID:	FBgn0038641	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_021332411.1	Gene:	slc5a7a / 100005589	ZFINID:	ZDB-GENE-090313-273	Length:	592	Species:	Danio rerio

Alignment Length:	534	Identity:	312/534 - (58%)
Similarity:	390/534 - (73%)	Gaps:	36/534 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INIAGVVSIVLFYLLILVVGIWAGRKKQS-----GNDSEEEVMLAGRSIGLFVGIFTMTATWVGG 61
            |::.|:|:||:||||||:|||||..|.::     |.|..|.:|:.||.||||||.||||||||||
Zfish     3 IHVEGLVAIVIFYLLILLVGIWAAWKNKNSGVMEGTDRSETIMVGGRDIGLFVGAFTMTATWVGG 67

  Fly    62 GYINGTAEAIYTS--GLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGERMGGLL 124
            ||||||||.:|..  ||.|.|||||||||||.||:|||.|||.:||:|||||.|..:|:||||||
Zfish    68 GYINGTAEYVYLPGFGLAWAQAPFGYALSLVLGGLFFAKPMRSRGYVTMLDPFQQLYGKRMGGLL 132

  Fly   125 FLPALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCI 189
            |:|||.||:||:|.||:|||||||||||:|...||::|:.|||||||.|||||||||||:|||||
Zfish   133 FIPALMGEMFWSAAILSALGATLSVIIDIDINMSVVISALIAIFYTLVGGLYSVAYTDVVQLFCI 197

  Fly   190 FIGLWMCIPFAWSNEHVGSLSDLEVD-----------WIGHVEPKKHWLYIDYGLLLVFGGIPWQ 243
            |:|||:.:|||.||.   ::||:.|.           |:|.:|....|::.|...||:.||||||
Zfish   198 FLGLWVSVPFALSNP---AVSDIGVTAVKQLHANQTAWLGKIESSDKWMWADNFCLLMLGGIPWQ 259

  Fly   244 VYFQRVLSSKTAGRAQLLSYVAAAGCILMAIPPVLIGAIAKATPWNETDYKGPY-PLTVDETSMI 307
            ||||||||:.:|..||:||::||.|||:||||.||||||..:|.||:|.| ||. |:..|::.||
Zfish   260 VYFQRVLSASSATYAQVLSFLAAFGCIIMAIPSVLIGAIGASTDWNQTSY-GPIPPMQKDQSDMI 323

  Fly   308 LPMVLQYLTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVA 372
            ||:|||:|.|.::|||||||||||||||||||:|||:||||||:|:|.|||.||:.||:||||:.
Zfish   324 LPIVLQHLCPAYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLAFRQSASDREIVWVMRIT 388

  Fly   373 IIVVGILATIMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKHCNTYGSLSAYIVALAIRLS 437
            |.|.|.|||.|||...::||||.:.|||||||:|||||.|: |.:..|||||::.|...|.:|:.
Zfish   389 IFVFGALATAMALLTGTVYGLWYLSSDLVYVIIFPQLLSVL-FIRGTNTYGSVAGYFFGLILRIG 452

  Fly   438 GGEAILGLAPLIKYPGYDEETK------------EQMFPFRTMAMLLSLVTLISVSWWTKMMFES 490
            |||..|.|.|.|.|||:..|.|            .|.|||:|.:||.|.::.::.|:..|.:|||
Zfish   453 GGEPYLKLPPFIYYPGWTIEEKVHHLTHEVEYLVMQRFPFKTASMLASFLSNVAFSYLFKYLFES 517

  Fly   491 GKLPPSYDYFRCVV 504
            |.|...||:...||
Zfish   518 GTLSAKYDFLDAVV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	299/504 (59%)
slc5a7a	XP_021332411.1	SLC5sbd_CHT	8..508	CDD:271368	299/504 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	512	1.000	Domainoid score	I308
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32516
Inparanoid	1	1.050	603	1.000	Inparanoid score	I904
OMA	1	1.010	-	-		QHG62377
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004760
OrthoInspector	1	1.000	-	-		otm25079
orthoMCL	1	0.900	-	-		OOG6_104374
Panther	1	1.100	-	-	O	PTHR45897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2785
SonicParanoid	1	1.000	-	-		X3349
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.000