DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7702 and chad

DIOPT Version :9

Sequence 1:	NP_650740.1	Gene:	CG7702 / 42242	FlyBaseID:	FBgn0038638	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_957357.1	Gene:	chad / 394038	ZFINID:	ZDB-GENE-040426-1130	Length:	363	Species:	Danio rerio

Alignment Length:	465	Identity:	100/465 - (21%)
Similarity:	165/465 - (35%)	Gaps:	152/465 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HKLLLL----FLAGAALLLATEVRSQHEDIPYQPVSNICQTCLCLSTQDVDHRTHFNLDCSVRNF 63
            |.||:|    |.|..|....|:..||               |.|          |.:|
Zfish     5 HVLLVLVCLQFCAHTAFAAPTQCPSQ---------------CHC----------HGDL------- 37

  Fly    64 EHILARWPEQFGSQAIASGAASEIVVSYSGNRIKLLQQLPATNAS-----LTLSCRHCGLQDLQA 123
            :|::.   :..|.:.|...:.:..:::...|.   |..||....|     ::|..:||.:::|..
Zfish    38 QHVIC---DNVGLKKIPRISEATRLLNLQRNN---LGNLPTGGFSEMKGLISLHLQHCQIRELSG 96

  Fly   124 PLFMDVPNVQALYISWNDIT------------------DDALVPDLFRGPFRNTRYEP-IGLRDL 169
            ..|..:..:..||:|.|:|:                  |...:..|.:|.|     .| |.|..|
Zfish    97 QAFKGLNKLIYLYLSDNEISTIKPGAFEDLTELTYLYLDGNQITSLPKGIF-----SPMINLFIL 156

  Fly   170 DLSHNRIVRLDRRLFEHTPHLTKLNLAYNKLSSLDEATTASIGSVATLQRLDLSHNGLMTLPAQL 234
            .|::|::..|....|:....|..|.::.|:|||:.   ..|:..|..|..|.|..|.|.|.|...
Zfish   157 QLNNNKLRELQPGTFKGAKDLRWLYMSGNELSSIQ---PGSLDEVENLAILTLDQNNLSTYPLLA 218

  Fly   235 FSKLTSLRFLDVSGNEFSTMP-ASLQLLGKSLVQLNLAGNAFLSLKENSLQGLVSLKRLNISSMP 298
            .|||..:..|::|.|..|.:| .:.:..|:.:.:|:|...:.......:.:|:.:||.|
Zfish   219 MSKLRVVEELNLSKNPLSLIPDHAFRSFGRYMEKLHLNDMSLEKFSNAAFEGVTALKSL------ 277

  Fly   299 SLRSLEKGALNLPALEHLDCSRNSKLERLELADLLSSRNLSQLDLSWNALTTLVINATGSSNNSS 363
                            ||:   |:||..|                               .|:..
Zfish   278 ----------------HLE---NNKLRSL-------------------------------PNSLE 292

  Fly   364 NSTNETWPRLRRMSISGNPWYCSCELFKALELIGLNHIDREWDGT-----EARCETPYLLAGSPL 423
            .||      ::.:::..|||.|:|.|...          |:|..|     :|.|.:|....|..:
Zfish   293 FST------IQNITLFNNPWSCTCPLTNL----------RKWMDTTRNRPDAVCASPANQKGKQI 341

  Fly   424 SNLTAERICK 433
            .:.||...||
Zfish   342 RDSTAFTRCK 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7702	NP_650740.1	leucine-rich repeat	110..131	CDD:275380	5/20 (25%)
		LRR_RI	<123..267	CDD:238064	42/163 (26%)
		leucine-rich repeat	132..165	CDD:275380	10/51 (20%)
		LRR_8	165..227	CDD:290566	18/61 (30%)
		leucine-rich repeat	166..189	CDD:275380	6/22 (27%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR_8	216..273	CDD:290566	18/57 (32%)
		leucine-rich repeat	217..240	CDD:275380	10/22 (45%)
		leucine-rich repeat	241..264	CDD:275380	6/23 (26%)
		LRR_8	263..321	CDD:290566	8/57 (14%)
		leucine-rich repeat	265..288	CDD:275380	3/22 (14%)
		leucine-rich repeat	289..312	CDD:275380	3/22 (14%)
		leucine-rich repeat	313..337	CDD:275380	6/23 (26%)
chad	NP_957357.1	LRRNT	26..52	CDD:279764	9/60 (15%)
		leucine-rich repeat	57..80	CDD:275380	5/25 (20%)
		LRR_8	79..139	CDD:290566	11/59 (19%)
		leucine-rich repeat	81..104	CDD:275380	5/22 (23%)
		LRR_RI	<96..304	CDD:238064	57/277 (21%)
		LRR_4	104..143	CDD:289563	6/38 (16%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		LRR_8	127..187	CDD:290566	15/64 (23%)
		leucine-rich repeat	129..152	CDD:275380	5/27 (19%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		LRR_8	177..235	CDD:290566	21/60 (35%)
		leucine-rich repeat	177..200	CDD:275380	8/25 (32%)
		leucine-rich repeat	201..224	CDD:275380	10/22 (45%)
		LRR_8	225..284	CDD:290566	15/83 (18%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		leucine-rich repeat	250..273	CDD:275380	3/22 (14%)
		LRRCT	304..351	CDD:214507	15/56 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D334557at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920