DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7702 and Lingo2

DIOPT Version :9

Sequence 1:	NP_650740.1	Gene:	CG7702 / 42242	FlyBaseID:	FBgn0038638	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	592	Identity:	137/592 - (23%)
Similarity:	223/592 - (37%)	Gaps:	151/592 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HEDIP-YQPVSNICQTCLCL-STQDVDHRTHFNLDCSVRNFEHILARWPEQFGSQAIASGAASEI 87
            |..|| :||...:....|.: ||.....|    .:||.:|
Mouse     3 HTAIPCWQPFLGLAVVLLLMGSTIGCPAR----CECSAQN------------------------- 38

  Fly    88 VVSYSGNRIKLL---QQLPATNASLTLSCRHCGLQDLQAPLFMDVPNVQALYISWNDITDDALVP 149
             .|.|.:|.:||   :.:|.....|.||...  |:.:....|:..|.::.:.:|.|.|.:  :.|
Mouse    39 -KSVSCHRRRLLAIPEGIPIETKILDLSKNR--LKSINPEEFISYPLLEEIDLSDNIIAN--VEP 98

  Fly   150 DLFRGPF--RNTRYE-------PIG-------LRDLDLSHNRIVRLDRRLFEHTPHLTKLNL--- 195
            ..|...|  |:.|.:       |:|       |..||:|.|:||.|...:|:...:|..|.:
Mouse    99 GAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDN 163

  Fly   196 --------AYNKLSSLDEAT----------TASIGSVATLQRLDLSHNGLMTLPAQLFSKLTSLR 242
                    |::.|.||::.|          |.::..:.:|..|.|.|..:..:|...|.:|..|:
Mouse   164 DLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPVYAFKRLFHLK 228

  Fly   243 FLDVS-GNEFSTMPAS----LQLLGKSLVQLNLAGNAFLSLKENSLQGLVSLKRLNISSMPSLRS 302
            .|::. ......|||:    |.|...|:...||:...||:.|.     ||.|..||:|..| :.:
Mouse   229 NLEIDYWPLLDLMPANSLYGLNLTSLSITNTNLSTVPFLAFKH-----LVYLTHLNLSYNP-IST 287

  Fly   303 LEKGAL-NLPALEHLDCSRNSKLERLELADLLSSRNLSQLDLSWNALTTLVINATGSSNNSSNST 366
            :|.|.. :|..|:.|... .::|..:|.......|.|..|::|.|.|.||..|...|
Mouse   288 IEAGMFSDLIRLQELHIV-GAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSS-------- 343

  Fly   367 NETWPR-LRRMSISGNPWYCSCELFKALELIGLNHIDREWDGTEARCETPYLLAGSPLSNLTAER 430
                || |..:||:.||..|.|.|...|:    ...:.::.|.:..|..|..:......:..:..
Mouse   344 ----PRALEVLSINNNPLACDCRLLWLLQ----RQPNLQFGGQQPMCAGPDTIRERSFKDFHSTA 400

  Fly   431 I-----CKMVIPKKYRE-------VDE------------EPPRFL-----RRHYIILTAIIASIV 466
            :     ||   ..|.||       |||            :|...:     ||.:|...:...:.|
Mouse   401 LSFYFTCK---KPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATV 462

  Fly   467 LVIG-LVIGF-------VVVCVRRRLKGSDYGVQPIRYTSVRGSNLSQF--SQLQPVSVASKFNN 521
            |..| |.|.|       :.||:.....|:|.....:   :|:|....:|  :...|:.:....:.
Mouse   463 LGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASL---TVKGFTSDRFLYANRTPMYMTDSNDT 524

  Fly   522 VHAGSSS 528
            |..|:::
Mouse   525 VSNGTNA 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7702	NP_650740.1	leucine-rich repeat	110..131	CDD:275380	4/20 (20%)
		LRR_RI	<123..267	CDD:238064	44/185 (24%)
		leucine-rich repeat	132..165	CDD:275380	9/41 (22%)
		LRR_8	165..227	CDD:290566	22/89 (25%)
		leucine-rich repeat	166..189	CDD:275380	9/22 (41%)
		leucine-rich repeat	190..213	CDD:275380	8/43 (19%)
		LRR_8	216..273	CDD:290566	17/61 (28%)
		leucine-rich repeat	217..240	CDD:275380	7/22 (32%)
		leucine-rich repeat	241..264	CDD:275380	7/27 (26%)
		LRR_8	263..321	CDD:290566	18/58 (31%)
		leucine-rich repeat	265..288	CDD:275380	6/22 (27%)
		leucine-rich repeat	289..312	CDD:275380	8/23 (35%)
		leucine-rich repeat	313..337	CDD:275380	4/23 (17%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	10/62 (16%)
		leucine-rich repeat	39..57	CDD:275380	5/17 (29%)
		LRR 1	58..79		5/22 (23%)
		leucine-rich repeat	59..82	CDD:275380	5/24 (21%)
		LRR_8	60..117	CDD:404697	14/60 (23%)
		LRR 2	82..103		5/22 (23%)
		leucine-rich repeat	83..106	CDD:275380	5/24 (21%)
		LRR_8	106..165	CDD:404697	15/58 (26%)
		LRR 3	106..127		4/20 (20%)
		leucine-rich repeat	107..130	CDD:275380	4/22 (18%)
		LRR 4	130..151		9/20 (45%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR 5	154..175		3/20 (15%)
		leucine-rich repeat	155..178	CDD:275380	4/22 (18%)
		PPP1R42	176..>373	CDD:411060	60/219 (27%)
		LRR 6	178..199		4/20 (20%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR 7	202..223		6/20 (30%)
		leucine-rich repeat	203..250	CDD:275380	12/46 (26%)
		LRR 8	226..247		5/20 (25%)
		LRR 9	250..271		6/20 (30%)
		leucine-rich repeat	251..274	CDD:275380	8/27 (30%)
		LRR 10	274..295		7/21 (33%)
		leucine-rich repeat	275..298	CDD:275380	8/23 (35%)
		LRR 11	298..319		4/21 (19%)
		leucine-rich repeat	299..322	CDD:275380	4/23 (17%)
		LRR 12	322..343		8/20 (40%)
		leucine-rich repeat	323..343	CDD:275380	8/19 (42%)
		LRRCT	355..408	CDD:214507	9/56 (16%)
		Ig	411..500	CDD:416386	20/91 (22%)
		Ig strand A'	417..421	CDD:409353	0/3 (0%)
		Ig strand B	427..436	CDD:409353	0/8 (0%)
		Ig strand C	441..446	CDD:409353	0/4 (0%)
		Ig strand C'	449..451	CDD:409353	1/1 (100%)
		Ig strand D	460..463	CDD:409353	0/2 (0%)
		Ig strand E	466..473	CDD:409353	3/6 (50%)
		Ig strand F	479..487	CDD:409353	2/7 (29%)
		Ig strand G	490..500	CDD:409353	2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910