DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7702 and iglr-3

DIOPT Version :9

Sequence 1:	NP_650740.1	Gene:	CG7702 / 42242	FlyBaseID:	FBgn0038638	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001293349.1	Gene:	iglr-3 / 171771	WormBaseID:	WBGene00021353	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	255	Identity:	70/255 - (27%)
Similarity:	110/255 - (43%)	Gaps:	62/255 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PATNASLTLSCR---HCGLQDLQAPLFMDVPNVQALYISWNDITDDALVPDLFRGPFRNTRYEPI 164
            |.|..|..:|.|   .|....||.|..: :|||.:|.:|.|.|             ||.|.: |.
Worm    20 PKTCKSFWISNRPSQDCASLTLQEPPQL-LPNVLSLSLSNNSI-------------FRITTF-PS 69

  Fly   165 GLRDLDLSHNRIVRLDRRLFEHTPHLTKLNLAYNKLSSLDEATTASIGSVATLQRLDLSHNGL-- 227
            ..|.|     :.:|||:...|        .|.::.||..::           |:.||:|.|.|
Worm    70 EYRRL-----QSLRLDQCQLE--------KLDFDALSVFEQ-----------LRELDVSRNSLSK 110

  Fly   228 MTLPAQLFSKLTSLRFLDVSGNEFSTMPASLQLLGKSLVQLNLAGNAFLSLKENSLQGLVSLKRL 292
            :.:|    ..|.|||.|:::.|.|:.:|....|  :||..::|:.|..:|::...|...:.:.||
Worm   111 LIIP----RNLASLRVLNLAFNAFTYVPDMSHL--ESLRLVDLSHNRLISVRPRMLPFNLEVVRL 169

  Fly   293 ------NISSMPSLRSLEKGALNLPALEHLDCSR---NSKLERLELAD--LLSSRNLSQL 341
                  ::|..|.|..|::..:....|| .|||.   .:..|:|.|.|  :|..|..|:|
Worm   170 AANRFQHLSPWPFLHKLQELDVTFNDLE-CDCSLWHFVTWAEKLALFDSTMLPCRRPSEL 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7702	NP_650740.1	leucine-rich repeat	110..131	CDD:275380	6/23 (26%)
		LRR_RI	<123..267	CDD:238064	39/145 (27%)
		leucine-rich repeat	132..165	CDD:275380	9/32 (28%)
		LRR_8	165..227	CDD:290566	14/61 (23%)
		leucine-rich repeat	166..189	CDD:275380	6/22 (27%)
		leucine-rich repeat	190..213	CDD:275380	3/22 (14%)
		LRR_8	216..273	CDD:290566	19/58 (33%)
		leucine-rich repeat	217..240	CDD:275380	8/24 (33%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR_8	263..321	CDD:290566	17/66 (26%)
		leucine-rich repeat	265..288	CDD:275380	5/22 (23%)
		leucine-rich repeat	289..312	CDD:275380	6/28 (21%)
		leucine-rich repeat	313..337	CDD:275380	10/28 (36%)
iglr-3	NP_001293349.1	LRR	<47..>196	CDD:227223	48/193 (25%)
		leucine-rich repeat	51..73	CDD:275380	9/35 (26%)
		leucine-rich repeat	74..97	CDD:275380	8/35 (23%)
		leucine-rich repeat	98..119	CDD:275380	8/24 (33%)
		leucine-rich repeat	120..141	CDD:275380	7/22 (32%)
		leucine-rich repeat	142..163	CDD:275380	5/20 (25%)
		leucine-rich repeat	164..185	CDD:275380	5/20 (25%)
		Ig_3	243..319	CDD:372822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24364
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030