Protein Alignment Cpsf73 and YSH1

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_013379.1
• Gene: YSH1 / 850983
• SGDID: S000004267
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 741
• Identity: 289/741 - (39%)
• Similarity: 437/741 - (58%)
• Gaps: 108/741 - (14%)

  Fly    23 LGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEADEIDLLFISHFHLDHCGALP 87
            ||...||||||.:|::|||.:|||.||||...|:.:||:.|..:..::|:|.||||||||..:||
Yeast    14 LGGSNEVGRSCHILQYKGKTVMLDAGIHPAYQGLASLPFYDEFDLSKVDILLISHFHLDHAASLP 78

  Fly    88 WFLMKTSFKGRCFMTHATKAIYRWMLSDYIKISNIST--------EQMLYTEADLEASMEKIETI 144
            :.:.:|:|:||.||||.|||||||:|.|::::::|.:        ::.|:::.||..|.:||||:
Yeast    79 YVMQRTNFQGRVFMTHPTKAIYRWLLRDFVRVTSIGSSSSSMGTKDEGLFSDEDLVDSFDKIETV 143

  Fly   145 NFHEERDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPMKPDVLIT 209
            ::|...||.|::|.|:.||||||||||.|||||:::|:|||:||:.||||.:|||||:..:|||.
Yeast   144 DYHSTVDVNGIKFTAFHAGHVLGAAMFQIEIAGLRVLFTGDYSREVDRHLNSAEVPPLSSNVLIV 208

  Fly   210 ESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPDL---HE 271
            |||:||..||.|.:||.:.|.|:...|.:|||.|:||||||||||::|||||:|||:.|.   .:
Yeast   209 ESTFGTATHEPRLNRERKLTQLIHSTVMRGGRVLLPVFALGRAQEIMLILDEYWSQHADELGGGQ 273

  Fly   272 IPIYYASSLAKKCMAVYQTYINAMNDRIRRQI--AVNNPFVFRHISNLKGIDHFEDIGPCVIMAS 334
            :||:|||:||||||:|:|||:|.|||.||::.  :..|||:|::||.|:.::.|:|.||.|::||
Yeast   274 VPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPFIFKNISYLRNLEDFQDFGPSVMLAS 338

  Fly   335 PGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQK--LPLNMSVDYI 397
            |||:||||||:|.|.||.:.||.|:|.||.:|||:||.::.||:.|.:::..:  :|....|:.|
Yeast   339 PGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMAKFIMLEPDTIPSINNPEITIPRRCQVEEI 403

  Fly   398 SFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTD--IKFYNPRNTHAV 460
            ||:||.|:|:..|||..:...:::|||||.|.|.|||.||...:.:...||  :..:||||...|
Yeast   404 SFAAHVDFQENLEFIEKISAPNIILVHGEANPMGRLKSALLSNFASLKGTDNEVHVFNPRNCVEV 468

  Fly   461 DLYFRGEKTAKVMGSLAAK---------NSEVGSKL----------------------------- 487
            ||.|:|.|.||.:|::..:         ..|:.:|:
Yeast   469 DLEFQGVKVAKAVGNIVNEIYKEENVEIKEEIAAKIEPIKEENEDNLDSQAEKGLVDEEEHKDIV 533

  Fly   488 -SGVLVKRD--FKYHLLAPSDLGK-YTDMSMSVVTQRQS---------IPWG--SSLSTLELLL- 536
             ||:||..|  |:...|:.|||.: :.|:|.:::.:|||         |.|.  ......|:|.
Yeast   534 VSGILVSDDKNFELDFLSLSDLREHHPDLSTTILRERQSVRVNCKKELIYWHILQMFGEAEVLQD 598

  Fly   537 -DRIGAGCVEVLEAERK---------LRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLACIMQ 591
             ||:.....:|.|..:.         |::.|.|:||:...:.|:||....:||..||:::|.:|.
Yeast   599 DDRVTNQEPKVKEESKDNLTNTGKLILQIMGDIKLTIVNTLAVVEWTQDLMNDTVADSIIAILMN 663

  Fly   592 SELGGTNLKGATKQTKSED---------------SRFRECLIETLQDTFGDNCVPKMFEGDLLP- 640
            .:....::|.::......|               .|.:: :....::.||| |.......|...
Yeast   664 VDSAPASVKLSSHSCDDHDHNNVQSNAQGKIDEVERVKQ-ISRLFKEQFGD-CFTLFLNKDEYAS 726

  Fly   641 ---------VTVSGKRAEINLETLAI 657
                     ||:....|:|:...:.|
Yeast   727 NKEETITGVVTIGKSTAKIDFNNMKI 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	100/195 (51%)
		YSH1	19..427	CDD:440849	214/418 (51%)
		CPSF73-100_C	486..680	CDD:463330	51/252 (20%)
YSH1	NP_013379.1	CPSF3-like_MBL-fold	9..210	CDD:293850	100/195 (51%)
		YSH1	14..432	CDD:440849	213/417 (51%)
		CPSF73-100_C	533..777	CDD:463330	50/222 (23%)