Protein Alignment Cpsf73 and Ints11

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_082296.1
• Gene: Ints11 / 71957
• MGIID: 1919207
• Length: 600
• Species: Mus musculus
• Alignment Length: 664
• Identity: 223/664 - (33%)
• Similarity: 329/664 - (49%)
• Gaps: 129/664 - (19%)

  Fly    10 MPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIE-----ADE 69
            ||:     :::.||||||:||||||::...||.:|||||:|.|.:.....|....|.     .|.
Mouse     1 MPE-----IRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDF 60

  Fly    70 IDLLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKI-------SNISTEQM 127
            :|.:.|||||||||||||:|.....:.|..:|||.|:||...:|.||.||       :|..|.||
Mouse    61 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQM 125

  Fly   128 LYTEADLEASMEKIETINFHEE---RDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQ 189
                  ::..|:|:..::.|:.   .|.:.::  ||.||||||||||.|::....::||||::..
Mouse   126 ------IKDCMKKVVAVHLHQTVQVDDELEIK--AYYAGHVLGAAMFQIKVGSESVVYTGDYNMT 182

  Fly   190 EDRHLMAAEVPPMKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQE 254
            .||||.||.:...:|::|||||||.|.|.:.:..||..|...|.:.|::||:.||||||||||||
Mouse   183 PDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQE 247

  Fly   255 LLLILDEFWSQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKG 319
            |.::|:.|| :..:| ::|||:::.|.:|....|:.:|...|.:||:.....|.|.|:||   |.
Mouse   248 LCILLETFW-ERMNL-KVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHI---KA 307

  Fly   320 IDH-FED-IGPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITT 382
            .|. |.| .||.|:.|:|||:.:|.|.::|..|..:.||.||:.||||:||:...:||...::..
Mouse   308 FDRTFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEM 372

  Fly   383 LSGQKLPLNMSVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADAST 447
            ...|.|.:.|.|:|:|||||.|.:...:.:...:|..|:|||||..:|..|:..:::|:.
Mouse   373 EGRQMLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFR----- 432

  Fly   448 DIKFYNPRNTHAVDLYFRGE----------KTAKVMGSL-AAKNSEVGSKLSGVLVKRDFKYHLL 501
             :..|.|.|...|.|.....          |...|.|.| .||...:   |.|.|:.:|..:.|:
Mouse   433 -VSCYMPANGETVTLPTSPSIPVGISLGLLKREMVQGLLPEAKKPRL---LHGTLIMKDSNFRLV 493

  Fly   502 APSDLGKYTDMSMSVVTQRQSIPWGSSLSTLELLLDRIGAGCVEVLEAERK-----LRVFG---- 557
            :..                      .:|..|.|...::...|...|:..||     |||:.
Mouse   494 SSE----------------------QALKELGLAEHQLRFTCRVHLQDTRKEQETALRVYSHLKS 536

  Fly   558 -----CIE------LTVEQ--------------KIIVMEWQATHVNDVYADAVLACIMQSELGG- 596
                 |::      :|||.              |::::.|       .|.|        .|||.
Mouse   537 TLKDHCVQHLPDGSVTVESILIQAAAHSEDPGTKVLLVSW-------TYQD--------EELGSF 586

  Fly   597 --TNLKGATKQTKS 608
              |.||....|..|
Mouse   587 LTTLLKNGLPQAPS 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	86/207 (42%)
		YSH1	19..427	CDD:440849	175/424 (41%)
		CPSF73-100_C	486..680	CDD:463330	31/160 (19%)
Ints11	NP_082296.1	COG1782	4..446	CDD:441388	183/460 (40%)
		INTS11-like_MBL-fold	6..204	CDD:293849	86/205 (42%)
		HXHXDH motif	68..73		4/4 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q5TA45	469..479		3/12 (25%)