DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf73 and Ints11

DIOPT Version :9

Sequence 1:	NP_650738.1	Gene:	Cpsf73 / 42240	FlyBaseID:	FBgn0261065	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_082296.1	Gene:	Ints11 / 71957	MGIID:	1919207	Length:	600	Species:	Mus musculus

Alignment Length:	664	Identity:	223/664 - (33%)
Similarity:	329/664 - (49%)	Gaps:	129/664 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIE-----ADE 69
            ||:     :::.||||||:||||||::...||.:|||||:|.|.:.....|....|.     .|.
Mouse     1 MPE-----IRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDF 60

  Fly    70 IDLLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKI-------SNISTEQM 127
            :|.:.|||||||||||||:|.....:.|..:|||.|:||...:|.||.||       :|..|.||
Mouse    61 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQM 125

  Fly   128 LYTEADLEASMEKIETINFHEE---RDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQ 189
                  ::..|:|:..::.|:.   .|.:.::  ||.||||||||||.|::....::||||::..
Mouse   126 ------IKDCMKKVVAVHLHQTVQVDDELEIK--AYYAGHVLGAAMFQIKVGSESVVYTGDYNMT 182

  Fly   190 EDRHLMAAEVPPMKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQE 254
            .||||.||.:...:|::|||||||.|.|.:.:..||..|...|.:.|::||:.||||||||||||
Mouse   183 PDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQE 247

  Fly   255 LLLILDEFWSQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKG 319
            |.::|:.|| :..:| ::|||:::.|.:|....|:.:|...|.:||:.....|.|.|:||   |.
Mouse   248 LCILLETFW-ERMNL-KVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHI---KA 307

  Fly   320 IDH-FED-IGPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITT 382
            .|. |.| .||.|:.|:|||:.:|.|.::|..|..:.||.||:.||||:||:...:||...::..
Mouse   308 FDRTFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEM 372

  Fly   383 LSGQKLPLNMSVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADAST 447
            ...|.|.:.|.|:|:|||||.|.:...:.:...:|..|:|||||..:|..|:..:::|:.
Mouse   373 EGRQMLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFR----- 432

  Fly   448 DIKFYNPRNTHAVDLYFRGE----------KTAKVMGSL-AAKNSEVGSKLSGVLVKRDFKYHLL 501
             :..|.|.|...|.|.....          |...|.|.| .||...:   |.|.|:.:|..:.|:
Mouse   433 -VSCYMPANGETVTLPTSPSIPVGISLGLLKREMVQGLLPEAKKPRL---LHGTLIMKDSNFRLV 493

  Fly   502 APSDLGKYTDMSMSVVTQRQSIPWGSSLSTLELLLDRIGAGCVEVLEAERK-----LRVFG---- 557
            :..                      .:|..|.|...::...|...|:..||     |||:.
Mouse   494 SSE----------------------QALKELGLAEHQLRFTCRVHLQDTRKEQETALRVYSHLKS 536

  Fly   558 -----CIE------LTVEQ--------------KIIVMEWQATHVNDVYADAVLACIMQSELGG- 596
                 |::      :|||.              |::::.|       .|.|        .|||.
Mouse   537 TLKDHCVQHLPDGSVTVESILIQAAAHSEDPGTKVLLVSW-------TYQD--------EELGSF 586

  Fly   597 --TNLKGATKQTKS 608
              |.||....|..|
Mouse   587 LTTLLKNGLPQAPS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	YSH1	18..456	CDD:224157	181/454 (40%)
		CPSF3-like_MBL-fold	18..211	CDD:293850	86/207 (42%)
		Beta-Casp	252..373	CDD:214983	48/122 (39%)
		RMMBL	386..426	CDD:284853	16/39 (41%)
		CPSF73-100_C	483..683	CDD:215023	31/163 (19%)
Ints11	NP_082296.1	YSH1	4..444	CDD:224157	182/458 (40%)
		INTS11-like_MBL-fold	6..204	CDD:293849	86/205 (42%)
		HXHXDH motif	68..73		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53735
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820