DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf73 and ints11

DIOPT Version :9

Sequence 1:	NP_650738.1	Gene:	Cpsf73 / 42240	FlyBaseID:	FBgn0261065	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001018457.1	Gene:	ints11 / 553648	ZFINID:	ZDB-GENE-050522-13	Length:	598	Species:	Danio rerio

Alignment Length:	685	Identity:	225/685 - (32%)
Similarity:	353/685 - (51%)	Gaps:	110/685 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIE-----ADE 69
            |||     :::.||||||:||||||::...||.||||||:|.|.:.....|....|.     .:.
Zfish     1 MPD-----IKVTPLGAGQDVGRSCILVSIGGKNIMLDCGMHMGFNDDRRFPDFSYITQNGRLTEF 60

  Fly    70 IDLLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKI-------SNISTEQM 127
            :|.:.|||||||||||||:......:.|..:|||.||||...:|.|:.||       :|..|.||
Zfish    61 LDCVIISHFHLDHCGALPYMSEMVGYDGPIYMTHPTKAICPILLEDFRKITVDKKGETNFFTSQM 125

  Fly   128 LYTEADLEASMEKIETINFHEE---RDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQ 189
                  ::..|:|:..:|.|:.   .|.:.::  ||.|||||||||..|::....::||||::..
Zfish   126 ------IKDCMKKVVPLNLHQTVQVDDELEIK--AYYAGHVLGAAMVQIKVGSESVVYTGDYNMT 182

  Fly   190 EDRHLMAAEVPPMKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQE 254
            .||||.||.:...:||:||:||||.|.|.:.:..||..|...|.:.|::||:.||||||||||||
Zfish   183 PDRHLGAAWIDKCRPDILISESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQE 247

  Fly   255 LLLILDEFWSQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKG 319
            |.::|:.|| :..:| :.|||:::.|.:|....|:.:|...|.:||:.....|.|.|:||   |.
Zfish   248 LCILLETFW-ERMNL-KAPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHI---KA 307

  Fly   320 ID--HFEDIGPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITT 382
            .|  :.::.||.|:.|:|||:.:|.|.::|:.|..:.||.||:.||||:||:...:|:..:::..
Zfish   308 FDRSYADNPGPMVVFATPGMLHAGQSLQIFKKWAGNEKNMVIMPGYCVQGTVGHKILNGQKKLEM 372

  Fly   383 LSGQKLPLNMSVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADAST 447
            .....|.:.:.|:|:|||||.|.:...:.||:.:|.:::|||||..:|..||..:::|:
Zfish   373 EGRATLDVKLQVEYMSFSAHADAKGIMQLIRMAEPRNMLLVHGEAKKMEFLKDKIEQEF------ 431

  Fly   448 DIKFYNPRNTHAVDLYFRGEKTAKVMGSLAAKNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDM 512
            .|..:.|.|         ||.|..|      .|..|...:|..|:||:.......| |..:...|
Zfish   432 SISCFMPAN---------GETTTIV------TNPSVPVDISLNLLKREMALGGPLP-DAKRPRTM 480

  Fly   513 SMSVVTQRQSIPWGSSLSTLELLLDRIGAGCVEVLEAERKLRVFGCIELTVEQKIIVMEWQATHV 577
            ..:::.:..|:    .|.:.|..|..:|..       |.:|| |.|               ...:
Zfish   481 HGTLIMKDNSL----RLVSPEQALKELGLN-------EHQLR-FTC---------------RVQL 518

  Fly   578 NDVYADA-VLACIMQSELGGTNLKGATKQTKSEDSRFRECLIETLQDTFGDNCVPKMFEGDLLPV 641
            :|.::|. .|:.|.      |:||...|....:.......::|::                ::.|
Zfish   519 HDPHSDTDTLSRIY------THLKSVLKSYSIQHVPDGTVIVESI----------------VIKV 561

  Fly   642 TVSGKRAEINLETLAISCA-EDDVLRQMLNTTVQK 675
            |.|.:  |.||:.:.:|.: :|:.|...|:|.::|
Zfish   562 TSSAE--EPNLKVILLSWSYQDEELGSFLSTLLKK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	YSH1	18..456	CDD:224157	177/454 (39%)
		CPSF3-like_MBL-fold	18..211	CDD:293850	85/207 (41%)
		Beta-Casp	252..373	CDD:214983	46/122 (38%)
		RMMBL	386..426	CDD:284853	15/39 (38%)
		CPSF73-100_C	483..683	CDD:215023	39/195 (20%)
ints11	NP_001018457.1	YSH1	4..442	CDD:224157	178/465 (38%)
		INTS11-like_MBL-fold	6..204	CDD:293849	85/205 (41%)
		HXHXDH motif	68..73		4/4 (100%)
		Beta-Casp	245..363	CDD:214983	46/122 (38%)
		RMMBL	377..416	CDD:284853	15/38 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53735
OrthoDB	1	1.010	-	-		D210835at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930