Protein Alignment Cpsf73 and Cpsf3

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_061283.2
• Gene: Cpsf3 / 54451
• MGIID: 1859328
• Length: 684
• Species: Mus musculus
• Alignment Length: 679
• Identity: 457/679 - (67%)
• Similarity: 541/679 - (79%)
• Gaps: 10/679 - (1%)

  Fly    10 MPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEADEIDLLF 74
            :|.||||.|.|:|||||||||||||:|||||:||||||||||||.|||||||:|||:..|||||.
Mouse     4 IPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLL 68

  Fly    75 ISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKISNISTEQMLYTEADLEASME 139
            ||||||||||||||||.|||||||.||||||||||||:||||:|:||||.:.|||||.|||.||:
Mouse    69 ISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEESMD 133

  Fly   140 KIETINFHEERDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPMKP 204
            |||||||||.::|.|::|..|.||||||||||||||||:|:||||||||||||||||||:|.:||
Mouse   134 KIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKP 198

  Fly   205 DVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPDL 269
            |:||.|||||||||||||:||.||.:.|..||.:|||.|||||||||||||||||||:|..:|:|
Mouse   199 DILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPEL 263

  Fly   270 HEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGIDHFEDIGPCVIMAS 334
            |:||||||||||||||||||||:|||||:||:||.:||||||:||||||.:|||:||||.|:|||
Mouse   264 HDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMAS 328

  Fly   335 PGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQKLPLNMSVDYISF 399
            |||:|:|||||||||||||.:||||||||||||||||.::||||||||:|||||||.||||||||
Mouse   329 PGMIQNGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISF 393

  Fly   400 SAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNTHAVDLYF 464
            ||||||||||||||.|||.||:|||||||||:|||.||.||||.:....|:.:|||||.||.|.|
Mouse   394 SAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNF 458

  Fly   465 RGEKTAKVMGSLAAKNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDMSMSVVTQRQSIPWGSSL 529
            ||||.|||||.||.|..|.|.::||:||||:|.||:|:|.||..|||::||.|.|.|:||:....
Mouse   459 RGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPF 523

  Fly   530 STLELLLDRIGAGCVEVLEAERK--LRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLACIMQS 592
            ..|...|.:: .|.||.||.:.|  |:||..|.:..|..::|:||.|...||:|||.|...|::.
Mouse   524 YLLYYQLQKL-TGDVEELEIQEKPALKVFKSITVVQEPGMVVLEWLANPSNDMYADTVTTVILEV 587

  Fly   593 ELGGTNLKGATKQT--KSEDSRFRECLIETLQDTFGDNCVPKMFEGDLLPVTVSGKRAEINLETL 655
            :......|||.::.  |.|...:.:.|...|||.||::|| .:.:..:|.|||.||.|.|||||.
Mouse   588 QSNPKIRKGAVQKVSKKLEMHVYSKRLEVMLQDIFGEDCV-SVKDDSVLSVTVDGKTANINLETR 651

  Fly   656 AISCAE----DDVLRQMLNTTVQKLHQTL 680
            |:.|.|    |:.||:|:....|:|::.|
Mouse   652 AVECEEGSEDDESLREMVELAAQRLYEAL 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	155/192 (81%)
		YSH1	19..427	CDD:440849	331/407 (81%)
		CPSF73-100_C	486..680	CDD:463330	81/201 (40%)
Cpsf3	NP_061283.2	CPSF3-like_MBL-fold	12..205	CDD:293850	155/192 (81%)
		YSH1	14..421	CDD:440849	331/406 (82%)
		CPSF73-100_C	479..682	CDD:463330	82/204 (40%)