Protein Alignment Cpsf73 and CPSF2

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_059133.1
• Gene: CPSF2 / 53981
• HGNCID: 2325
• Length: 782
• Species: Homo sapiens
• Alignment Length: 816
• Identity: 167/816 - (20%)
• Similarity: 304/816 - (37%)
• Gaps: 251/816 - (30%)

  Fly    15 SDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEA-----DEIDLLF 74
            :.::::..|...||....|.:|:....:.:||||.....|       :|:|::     .:||.:.
Human     2 TSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFS-------MDIIDSLRKHVHQIDAVL 59

  Fly    75 ISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYR---WMLSDYIKISNISTEQMLYTEADLEA 136
            :||....|.||||:.:.|...  .|.: :||..:|:   ..:.|..:..:.:.:..|:|..|::|
Human    60 LSHPDPLHLGALPYAVGKLGL--NCAI-YATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDA 121

  Fly   137 SMEKIETINFHEERDVM----GVRFCAYIAGHVLGAAMFMIEIAG-IKILYTGDFSRQEDRHLMA 196
            :.:||:.:.|.:..::.    |:......|||::|..::.|...| .:|:|..||:.:.:.||..
Human   122 AFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNG 186

  Fly   197 AEVPPM-KPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILD 260
            ..:..: :|.:|||:|...|::..:|:.|:.:..:.|.:.::..|..||.|...||..||..:||
Human   187 CSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLD 251

  Fly   261 EFW-SQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRR--QIAVNNPFVFRHISNLKGIDH 322
            :.| :::..|....:...::::...:...::.:..|:|::.|  :...||||.|||:|...|:..
Human   252 QIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSD 316

  Fly   323 FEDI-GPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITT---- 382
            ...: .|.|::||...::.|.||:||..||.||||.:|:......||||:.::..|.|..|
Human   317 LARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKITEIEL 381

  Fly   383 -----LSGQKL------------------------------------------------------ 388
                 |.|::|
Human   382 RKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLMMKGE 446

  Fly   389 ---------------------------------------------------------------PL 390
                                                                           |:
Human   447 GSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPM 511

  Fly   391 NMS--------------------VDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKL 435
            :..                    |.||.:...:|.....:.|..:||..:::|||.......|..
Human   512 DQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAE 576

  Fly   436 ALQREYEADASTDIKFYNPRNTHAVD-------------------LYFRGEKTAK---VMGSLAA 478
            ..:    |....|||.|.|:....||                   |.|...|.|:   :.|.|..
Human   577 CCR----AFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDM 637

  Fly   479 KNSEVGSKLSGVLVK--------RDFKYHLLAPSDLGKYTDMSMSVVTQRQSIP--WGSS----- 528
            :.|:|.   :||:::        .|.:..:.||||        .||:.|::::.  :|..
Human   638 RVSKVD---TGVILEEGELKDDGEDSEMQVEAPSD--------SSVIAQQKAMKSLFGDDEKETG 691

  Fly   529 -----LSTLELLLDRIGAGCVEVLEAERKLRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLAC 588
                 :.|||.|......|...|...|.:|..|        :::::.|    .:...:...||.|
Human   692 EESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDF--------KQVLLRE----GIQAEFVGGVLVC 744

  Fly   589 -----IMQSELGGTNLKGATKQTKSEDSRFRECLIE 619
                 :.::|.|...|:|...|   :..|.|:.|.|
Human   745 NNQVAVRRTETGRIGLEGCLCQ---DFYRIRDLLYE 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	51/206 (25%)
		YSH1	19..427	CDD:440849	117/571 (20%)
		CPSF73-100_C	486..680	CDD:463330	33/159 (21%)
CPSF2	NP_059133.1	CPSF2-like_MBL-fold	7..204	CDD:293851	52/206 (25%)
		Beta-Casp	243..368	CDD:214983	38/124 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	407..449		0/41 (0%)
		RMMBL	528..591	CDD:462191	16/66 (24%)
		CPSF100_C	608..779	CDD:463836	41/196 (21%)