Protein Alignment Cpsf73 and CPSF3

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001308765.1
• Gene: CPSF3 / 51692
• HGNCID: 2326
• Length: 688
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 448/665 - (67%)
• Similarity: 530/665 - (79%)
• Gaps: 10/665 - (1%)

  Fly    24 GAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEADEIDLLFISHFHLDHCGALPW 88
            |||||||||||:|||||:||||||||||||.|||||||:|||:..|||||.||||||||||||||
Human    22 GAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPW 86

  Fly    89 FLMKTSFKGRCFMTHATKAIYRWMLSDYIKISNISTEQMLYTEADLEASMEKIETINFHEERDVM 153
            ||.|||||||.||||||||||||:||||:|:||||.:.|||||.|||.||:|||||||||.::|.
Human    87 FLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVA 151

  Fly   154 GVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPMKPDVLITESTYGTHIH 218
            |::|..|.||||||||||||||||:|:||||||||||||||||||:|.:|||:||.|||||||||
Human   152 GIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIH 216

  Fly   219 EKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPDLHEIPIYYASSLAKK 283
            ||||:||.||.:.|..||.:|||.|||||||||||||||||||:|..:|:||:||||||||||||
Human   217 EKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAKK 281

  Fly   284 CMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGIDHFEDIGPCVIMASPGMMQSGLSRELFE 348
            ||||||||:|||||:||:||.:||||||:||||||.:|||:||||.|:|||||||||||||||||
Human   282 CMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFE 346

  Fly   349 SWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQKLPLNMSVDYISFSAHTDYQQTSEFIR 413
            |||||.:||||||||||||||||.::||||||||:|||||||.||||||||||||||||||||||
Human   347 SWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIR 411

  Fly   414 LLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNTHAVDLYFRGEKTAKVMGSLAA 478
            .|||.||:|||||||||:|||.||.||||.:....|:.:|||||.||.|.|||||.|||||.||.
Human   412 ALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLAD 476

  Fly   479 KNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDMSMSVVTQRQSIPWGSSLSTLELLLDRIGAGC 543
            |..|.|.::||:||||:|.||:|:|.||..|||::||.|.|.|:||:....:.|...|.:: .|.
Human   477 KKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFNLLCYQLQKL-TGD 540

  Fly   544 VEVLEAERK--LRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLACIMQSELGGTNLKGATKQT 606
            ||.||.:.|  |:||..|.:..|..::|:||.|...||:|||.|...|::.:......|||.::.
Human   541 VEELEIQEKPALKVFKNITVIQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKV 605

  Fly   607 --KSEDSRFRECLIETLQDTFGDNCVPKMFEGDLLPVTVSGKRAEINLETLAISCAE----DDVL 665
              |.|...:.:.|...|||.||::|| .:.:..:|.|||.||.|.:||||..:.|.|    |:.|
Human   606 SKKLEMHVYSKRLEIMLQDIFGEDCV-SVKDDSILSVTVDGKTANLNLETRTVECEEGSEDDESL 669

  Fly   666 RQMLNTTVQKLHQTL 680
            |:|:....|:|::.|
Human   670 REMVELAAQRLYEAL 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	151/186 (81%)
		YSH1	19..427	CDD:440849	330/402 (82%)
		CPSF73-100_C	486..680	CDD:463330	79/201 (39%)
CPSF3	NP_001308765.1	COG1782	18..460	CDD:441388	352/437 (81%)
		CPSF3-like_MBL-fold	22..209	CDD:293850	151/186 (81%)
		CPSF73-100_C	483..686	CDD:463330	80/204 (39%)