DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf73 and cpsf3

DIOPT Version :9

Sequence 1:	NP_650738.1	Gene:	Cpsf73 / 42240	FlyBaseID:	FBgn0261065	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001006770.1	Gene:	cpsf3 / 448456	XenbaseID:	XB-GENE-972322	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	454/688 - (65%)
Similarity:	544/688 - (79%)	Gaps:	16/688 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DARMPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEADEID 71
            ::.:|.||||.|.|:|||||||||||||:|||||:||||||||||||.|||||||:|||:..|||
Frog     8 ESAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEID 72

  Fly    72 LLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKISNISTEQMLYTEADLEA 136
            ||.||||||||||||||||.|||||||.||||||||||||:||||:|:||||.:.|||||.|||.
Frog    73 LLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEE 137

  Fly   137 SMEKIETINFHEERDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPP 201
            ||:|||||||||.::|.|::|..|.||||||||||||||||:|:||||||||||||||||||:|.
Frog   138 SMDKIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPN 202

  Fly   202 MKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQN 266
            :|||:||.|||||||||||||:||.||.:.|..||.:|||.|||||||||||||||||||:|..:
Frog   203 VKPDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRALIPVFALGRAQELLLILDEYWQNH 267

  Fly   267 PDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGIDHFEDIGPCVI 331
            |:||:||||||||||||||||||||:|||||:||:||.:||||||:||||||.:|||:||||.|:
Frog   268 PELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVV 332

  Fly   332 MASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQKLPLNMSVDY 396
            ||||||||||||||||||||||.:||||||||||||||||.::||||||.|:|||||||.|||||
Frog   333 MASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEIATMSGQKLPLKMSVDY 397

  Fly   397 ISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNTHAVD 461
            |||||||||||||||:|.|||.||:|||||||||:|||.||.||||.:...:|:.:|||||.||.
Frog   398 ISFSAHTDYQQTSEFVRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVEIEVHNPRNTEAVT 462

  Fly   462 LYFRGEKTAKVMGSLAAKNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDMSMSVVTQRQSIPWG 526
            |.|||||.|||||.||.|..|.|.::||:||||:|.||:|.||||..|||::||.|||:|:||:.
Frog   463 LNFRGEKLAKVMGLLADKKPEQGQRISGILVKRNFNYHILCPSDLSSYTDLAMSTVTQKQAIPYT 527

  Fly   527 SSLSTLELLLDRIGAGCVEVLEAERK--LRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLACI 589
            ...:.|...|.:: .|.||.:|...|  ||||..:.:..:..::.:||.|...||:|||.|:..|
Frog   528 GPFNLLSCQLQQL-TGDVEEIEVNEKDALRVFKAVTVVRDAGMVYLEWVANPANDMYADTVITVI 591

  Fly   590 MQSELGGTNLKG----ATKQTKSED-SRFRECLIETLQDTFGDNCVPKMFEGDLLPVTVSGKRAE 649
            ::.:   :|.|.    ||:.:|..| ..:|:.|...|||.|||:|| ...:...:.|||.||.|.
Frog   592 LELQ---SNPKANKAVATRASKEVDMDAYRKRLEMMLQDIFGDDCV-NCEDAGSITVTVDGKSAI 652

  Fly   650 INLETLAI----SCAEDDVLRQMLNTTVQKLHQTLVSA 683
            :::||..:    ...||:.||:|:....|:|:..|..|
Frog   653 LSMETRTVEYEEGIDEDETLREMVQQAAQRLYDALCPA 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	YSH1	18..456	CDD:224157	349/437 (80%)
		CPSF3-like_MBL-fold	18..211	CDD:293850	155/192 (81%)
		Beta-Casp	252..373	CDD:214983	101/120 (84%)
		RMMBL	386..426	CDD:284853	34/39 (87%)
		CPSF73-100_C	483..683	CDD:215023	79/210 (38%)
cpsf3	NP_001006770.1	CPSF3-like_MBL-fold	19..212	CDD:293850	155/192 (81%)
		YSH1	21..461	CDD:224157	351/439 (80%)
		CPSF73-100_C	486..689	CDD:314561	78/207 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1576
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6499
Inparanoid	1	1.050	908	1.000	Inparanoid score	I365
OMA	1	1.010	-	-		QHG53735
OrthoDB	1	1.010	-	-		D210835at33208
OrthoFinder	1	1.000	-	-		FOG0004389
OrthoInspector	1	1.000	-	-		oto102922
Panther	1	1.100	-	-	LDO	PTHR11203
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2011
SonicParanoid	1	1.000	-	-		X3673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110