Protein Alignment Cpsf73 and Ints11

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: XP_006239611.1
• Gene: Ints11 / 298688
• RGDID: 1306841
• Length: 629
• Species: Rattus norvegicus
• Alignment Length: 732
• Identity: 224/732 - (30%)
• Similarity: 340/732 - (46%)
• Gaps: 177/732 - (24%)

  Fly    10 MPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIE-----ADE 69
            ||:     :::.||||||:||||||::...||.:|||||:|.|.:.....|....|.     .|.
  Rat     2 MPE-----IRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDF 61

  Fly    70 IDLLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKI-------SNISTEQM 127
            :|.:.|||||||||||||:|.....:.|..:|||.|:||...:|.||.||       :|..|.||
  Rat    62 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQM 126

  Fly   128 LYTEADLEASMEKIETINFHEE---RDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQ 189
                  ::..|:|:..::.|:.   .|.:.::  ||.||||||||||.|::....::||||::..
  Rat   127 ------IKDCMKKVVAVHLHQTVQVDDELEIK--AYYAGHVLGAAMFQIKVGSESVVYTGDYNMT 183

  Fly   190 EDRHLMAAEVPPMKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQE 254
            .||||.||.:...:|::|||||||.|.|.:.:..||..|...|.:.|::||:.||||||||||||
  Rat   184 PDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQE 248

  Fly   255 LLLILDEFWSQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKG 319
            |.::|:.|| :..:| ::|||:::.|.:|....|:.:|...|.:||:.....|.|.|:||   |.
  Rat   249 LCILLETFW-ERMNL-KVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHI---KA 308

  Fly   320 IDH-FED-IGPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITT 382
            .|. |.| .||.|:.|:|||:.:|.|.::|..|..:.||.||:.||||:||:...:||...::..
  Rat   309 FDRTFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEM 373

  Fly   383 LSGQKLPLNMSVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADAST 447
            ...|.|.:.|.|:|:|||||.|.:...:.:...:|..|:|||||..:|..|:..:::|:.
  Rat   374 EGRQMLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFR----- 433

  Fly   448 DIKFYNPRNTHAVDL-------------YFRGEKTAKVMGSLA---------------------- 477
             :..|.|.|...|.|             ..:.|....:.|.|.
  Rat   434 -VSCYMPANGETVTLPTSPSIPVGISLGLLKREMVQGMKGRLGHGSRGQVTGGWVDCIIPFFTGL 497

  Fly   478 ---AKNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDMSMSVVTQRQSIPWGSSLSTLELLLDRI 539
               ||...:   |.|.|:.:|..:.|::.                             |..|..:
  Rat   498 LPEAKKPRL---LHGTLIMKDNNFRLVSS-----------------------------EQALKEL 530

  Fly   540 GAGCVEVLEAERKLRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLACIMQSELGGTNLKGATK 604
            |.       ||.:|| |.|               ..|:.|.
  Rat   531 GL-------AEHQLR-FTC---------------RVHLQDT------------------------ 548

  Fly   605 QTKSEDSRFRECLIETLQDTFGDNCVPKMFEGDLLPVTVSGKRAEINLETLAISCA---EDDVLR 666
             .|.:::..|  :...|:.|..|:||..:.:|            .:.:|::.|..|   ||...:
  Rat   549 -RKEQETALR--VYSHLKSTLKDHCVQHLPDG------------SVTVESILIQAAAHSEDPGTK 598

  Fly   667 QML-NTTVQKLHQTLVS 682
            .:| :.|.|....::.|
  Rat   599 VLLVSWTYQVRRMSITS 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	86/207 (42%)
		YSH1	19..427	CDD:440849	175/424 (41%)
		CPSF73-100_C	486..680	CDD:463330	32/197 (16%)
Ints11	XP_006239611.1	COG1782	5..447	CDD:441388	183/460 (40%)
		INTS11-like_MBL-fold	7..205	CDD:293849	86/205 (42%)