Protein Alignment Cpsf73 and Ints9

DIOPT Version :10

• Sequence 1: NP_650738.1
• Gene: Cpsf73 / 42240
• FlyBaseID: FBgn0261065
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001389188.1
• Gene: Ints9 / 290322
• RGDID: 1311539
• Length: 658
• Species: Rattus norvegicus
• Alignment Length: 687
• Identity: 144/687 - (20%)
• Similarity: 243/687 - (35%)
• Gaps: 200/687 - (29%)

  Fly    33 CIMLEFKGKKIMLDCGIH---------------------PGLSGMD------------------- 57
            |.:|:||...||||||:.                     ||.|..|
  Rat    14 CNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVD 78

  Fly    58 -----ALPYVDLIEADEIDLLFISHFHLDHC-GALPWFLMKTSFKGRCFMTHATKAIYRWMLSDY 116
                 .||..:||:...:|::.||::   || .|||:....|.|.|..:.|..|..|.|.::.:.
  Rat    79 SVPEFCLPETELIDLSTVDVILISNY---HCMMALPYITEHTGFTGTVYATEPTMQIGRLLMEEL 140

  Fly   117 IKI-----------------------------SNISTEQMLYTEADLEASMEKIETINFHEERDV 152
            :..                             ..:||.:..||..::.:::.||:.:.:.::.::
  Rat   141 VNFIERVPKAQSASLWKNKEIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIEL 205

  Fly   153 MG-VRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPM------KPDVLITE 210
            .| |:.....:|:.||::.::|:....|:.|....|      |:.....||      ..||||.
  Rat   206 FGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSS------LLTTHPQPMDQASLKNSDVLIL- 263

  Fly   211 STYGTHIHEKRED-RENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPDLHEIPI 274
             |..|.|.....| ....|.|.:...|:.||..|:|.:..|...:||..|.:: ..:..|..||.
  Rat   264 -TGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQY-IDSAGLSNIPF 326

  Fly   275 YYASSLAKKCMAVYQTYINAM-NDRIRRQIAVNNPFVFRHISNLKGIDHFEDI---------GPC 329
            |:.|.:|...:...|.:...: :::..:......||....:.....:.|:..|         .||
  Rat   327 YFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYRSIHGDFSHDFRQPC 391

  Fly   330 VIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPE--EITTLSGQKLPLNM 392
            |:......::.|......|.|.....|.||              .:||:  .:..|:..: ||.|
  Rat   392 VLFTGHPSLRFGDVVHFMELWGKSSLNTVI--------------FTEPDFSYLEALAPYQ-PLAM 441

  Fly   393 SVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNT 457
            ...|.......::.|.|:.::.::|.|||               ...:|....        |..:
  Rat   442 KCIYCPIDTRLNFIQVSKLLKEVQPLHVV---------------CPEQYTQPP--------PAQS 483

  Fly   458 HAVDL----------YFRGEKTA--------------KVMGSLAAKNSEVGSKL---SGVLVKRD 495
            |.:||          |.|.|..|              ::..||.....:.|..|   |.||..:|
  Rat   484 HRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKD 548

  Fly   496 FKYHLLAPSDLGKYTDMSMSVVTQR--QSIPWGSSLSTLELLLDRIGAGCVEVLEAERKLRVFGC 558
            .| |:|.|..  |.|..:.|...:|  :.:|   ....|:.||    :|.:.|.:..:.|...|.
  Rat   549 NK-HVLQPPP--KPTQPTSSKKRKRVSEDVP---DSKVLKPLL----SGSIPVEQFVQTLEKHGF 603

  Fly   559 IELTVE-------------QKIIVMEWQATHV---ND 579
            .::.||             :.:|.:|..:||:   ||
  Rat   604 SDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDND 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	CPSF3-like_MBL-fold	18..211	CDD:293850	55/259 (21%)
		YSH1	19..427	CDD:440849	103/488 (21%)
		CPSF73-100_C	486..680	CDD:463330	29/115 (25%)
Ints9	NP_001389188.1	Int9-like_MBL-fold	1..265	CDD:293852	55/261 (21%)
		Beta-Casp	307..425	CDD:214983	23/132 (17%)