DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf73 and cpsf-3

DIOPT Version :9

Sequence 1:	NP_650738.1	Gene:	Cpsf73 / 42240	FlyBaseID:	FBgn0261065	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_502553.2	Gene:	cpsf-3 / 178285	WormBaseID:	WBGene00013460	Length:	707	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	368/717 - (51%)
Similarity:	482/717 - (67%)	Gaps:	74/717 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEADEIDLLFISH 77
            :.||.|...|||:||||||||.:||:|||::|||||:||||.|:||||:||.:|.:.||||.|:|
Worm     6 DNSDSLCFTPLGSGQEVGRSCHLLEYKGKRVMLDCGVHPGLHGVDALPFVDFVEIENIDLLLITH 70

  Fly    78 FHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKISNIS--TEQMLYTEADLEASMEK 140
            |||||||||||.|.||:|:|:||||||||||||.:|.||::||...  ....||||.|||.||.|
Worm    71 FHLDHCGALPWLLQKTAFQGKCFMTHATKAIYRMLLGDYVRISKYGGPDRNQLYTEDDLEKSMAK 135

  Fly   141 IETINFHEERDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPMKPD 205
            ||||:|.|:::|.|:||..|:|||||||..|||||||:::|||||||..|||||.|||:||:.|.
Worm   136 IETIDFREQKEVNGIRFWPYVAGHVLGACQFMIEIAGVRVLYTGDFSCLEDRHLCAAEIPPITPQ 200

  Fly   206 VLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPDLH 270
            ||||||||||..||.|..||.|||.:|..||.:|||||||.||:|.||||:|||||:|..:.:||
Worm   201 VLITESTYGTQTHEDRAVREKRFTQMVHDIVTRGGRCLIPAFAIGPAQELMLILDEYWESHQELH 265

  Fly   271 EIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGIDHFEDIGPCVIMASP 335
            :||:|||||||||||:||||::|.||.||::||||.|||:|:|:|.|:|:|.|||.||||::|:|
Worm   266 DIPVYYASSLAKKCMSVYQTFVNGMNSRIQKQIAVKNPFIFKHVSTLRGMDQFEDAGPCVVLATP 330

  Fly   336 GMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQKLPLNMSVDYISFS 400
            ||:|||.|||||||||.|.|||.|||||||||||||.:|||||||.:|||:|||:.|.|.|:|||
Worm   331 GMLQSGFSRELFESWCPDTKNGCIIAGYCVEGTLAKHILSEPEEIVSLSGEKLPMRMQVGYVSFS 395

  Fly   401 AHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNTHAVDLYFR 465
            |||||.|||.|::.|||.|:||||||.:||||||..::|::: |.:..|:.:|||||..:.|.||
Worm   396 AHTDYHQTSNFVKALKPPHLVLVHGELHEMSRLKSGIERQFQ-DDNIPIEVHNPRNTERLQLQFR 459

  Fly   466 GEKTAKVMGSLAAKNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDMSMSVVTQRQSIPWGSSLS 530
            |||||||:|.||.:..|....:||||||.:|.|.::.|.:||.||.:.:|.:.||.|:.:..||.
Worm   460 GEKTAKVIGKLAQRVPENNETISGVLVKNNFSYSIMVPEELGSYTSLRISSLEQRMSVHYSGSLK 524

  Fly   531 TLELLLDRIG-AGC----VEVLEAERK------LRVF-GCIELTV--EQKIIVMEWQATHVNDVY 581
            .|...|.::. ..|    :::.|..:|      :.|| |.:.:||  ...::|:.|.:..|.|:|
Worm   525 LLIFNLQQLNDDACLIQNIKLKEISKKGSVTQAITVFQGKVNVTVYGNDHVVVVRWDSNPVYDMY 589

  Fly   582 ADAVLACIMQSELG----------------GTNLKGATKQTKSED-----------SRF----RE 615
            ||:|:|.|:.::..                .|.::|..|....:|           ::|    |.
Worm   590 ADSVVAAILHAQANPVPDKYLPSNSSFPQFNTAIEGMVKHICGDDVSIVMSERGLLAQFEEDGRR 654

  Fly   616 CLIETLQDTFGDNCVPKMFEGDLLPVTVSGKRAEINLETLAISCAEDDVLRQMLNTTVQKLHQTL 680
            .|:|      |.:..|.|..||                    ...:|.....:|....:|:.|.:
Worm   655 LLVE------GSSDGPVMMGGD--------------------DPMDDPTTSHLLQNLTEKMRQIV 693

  Fly   681 VS 682
            .:
Worm   694 TT 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf73	NP_650738.1	YSH1	18..456	CDD:224157	293/439 (67%)
		CPSF3-like_MBL-fold	18..211	CDD:293850	130/194 (67%)
		Beta-Casp	252..373	CDD:214983	87/120 (73%)
		RMMBL	386..426	CDD:284853	26/39 (67%)
		CPSF73-100_C	483..683	CDD:215023	56/245 (23%)
cpsf-3	NP_502553.2	CPSF3-like_MBL-fold	11..206	CDD:293850	130/194 (67%)
		YSH1	13..456	CDD:224157	295/443 (67%)
		Beta-Casp	247..368	CDD:214983	87/120 (73%)
		RMMBL	381..421	CDD:284853	26/39 (67%)
		CPSF73-100_C	477..694	CDD:215023	56/242 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166224
Domainoid	1	1.000	242	1.000	Domainoid score	I1244
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6499
Inparanoid	1	1.050	726	1.000	Inparanoid score	I319
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53735
OrthoDB	1	1.010	-	-		D210835at33208
OrthoFinder	1	1.000	-	-		FOG0004389
OrthoInspector	1	1.000	-	-		oto19938
orthoMCL	1	0.900	-	-		OOG6_101260
Panther	1	1.100	-	-	LDO	PTHR11203
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2011
SonicParanoid	1	1.000	-	-		X3673
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840