Protein Alignment MEP1A and mep1a.2

DIOPT Version :10

• Sequence 1: XP_011512930.1
• Gene: MEP1A / 4224
• HGNCID: 7015
• Length: 774
• Species: Homo sapiens
• Sequence 2: NP_001122199.1
• Gene: mep1a.2 / 565535
• ZFINID: ZDB-GENE-041001-208
• Length: 689
• Species: Danio rerio
• Alignment Length: 718
• Identity: 381/718 - (53%)
• Similarity: 474/718 - (66%)
• Gaps: 57/718 - (7%)

Human    55 LPEENVHDADFGE-QKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLN 118
            ||.:...|||.|| ::||.||||.:..:||:|||.....||.:.|...||.|||||||.|.|.||
Zfish    21 LPAQYGEDADAGELREDILEINLDSQRELFEGDIAGDPRRNAIIDEKARWQFPIPYILTDTLDLN 85

Human   119 AKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEH 183
            |||.||.|.||:|||||||||||||||:||.|.:.|||||.|||...|||:|||:.|..|||:||
Zfish    86 AKGVILQALEMYRLKSCVDFKPYEGESTYISFTKLDGCWSFVGDLKTGQNVSIGERCDTKAIVEH 150

Human   184 EILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFN 248
            |:||||||||||||:||||||.||||||:.|.:|||:.|:|..||||||||||||:|||:|.|||
Zfish   151 ELLHALGFYHEQSRSDRDDYVKIWWDQIIEGKEHNFNKYEDDFITDLNTPYDYESIMHYRPLSFN 215

Human   249 KNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRD 313
            |:..:||||..||.||:||||||||||:|||||||||.||.||||||.|.||:.|||||||...|
Zfish   216 KDPDIPTITTTIPAFNNIIGQRLDFSALDLERLNRMYECTATHTLLDQCAFEQINICGMIQNDED 280

Human   314 DTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKM 378
            |.||. |..:.....||||.|||..:||||:|.|.:.:...:||||||||||||.||||:|||:|
Zfish   281 DADWV-QTLSSTDLKDHTLGGQCRDSGYFMKFDTDNKTEGHSALLESRILYPKRNQQCLEFFYRM 344

Human   379 TGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNS 443
            :|.|.|:|::|||.||.||||.|:.||.|..|..|::|.||.|.|..::||||.|||..|  .|.
Zfish   345 SGEPGDKLIIWVRTDDGTGNVNKVRKVHTITGHGDNSWNIAQVTLNVKEKFRYFFQGIVG--PNK 407

Human   444 TGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSG 508
            |.||::|||.||||.||..||.::||:.:|.......|:||.||||||||.:|:.:|||.|.:|.
Zfish   408 TSGIFIDDIILTETSCPNTVWRIQNFTNLLNTLPHDAKVQSERFYNSEGYAYGINVYPNGRVNSS 472

Human   509 --YLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVI 571
              ::.:.|::..|||||:||||..||||.:|..||.||...:||:|..|||...         :.
Zfish   473 KEFVGITFNLFGGENDAVLEWPAVNRQVTVTAKDQNPDATLQMSNSRSFTTDAD---------MR 528

Human   572 WDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKG 636
            |::||....:...|.|||..:.||..||||..|:||.|||||||||.::|:|:.||.::|||||.
Zfish   529 WNKPSTFEQWDDSCLCFRGPEFGWGTFISHDQLRRRDFLKNDDLIITINFDDLAHLVKSEVPTKV 593

Human   637 KRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPS-RQKRSVENTGPLEDHNWPQYFRD 700
            .. :||                         |...:..:|. ||.|::.               |
Zfish   594 SN-NPQ-------------------------PAEKNIEKPKIRQPRAIS---------------D 617

Human   701 PCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSII 765
            .|.||||||.|.||..:|.|:|||.||.|..|||:.|:...:.|.::|::|||..|.:.||.:||
Zfish   618 LCQPNPCQNGGACVTHQGKATCRCASGQAVVYTGDTCEKQHIDGGIMGVLIGGAVGTVALTVAII 682

Human   766 AIL 768
            |::
Zfish   683 AVI 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	156/229 (68%)
		MAM	292..459	CDD:214533	95/166 (57%)
		MATH_Meprin_Alpha	459..622	CDD:239752	74/164 (45%)
		EGF	702..736	CDD:394967	21/33 (64%)
mep1a.2	NP_001122199.1	ZnMc	26..254	CDD:469599	156/227 (69%)
		MAM	264..424	CDD:459878	91/162 (56%)
		MATH	423..579	CDD:445786	74/164 (45%)
		EGF	619..653	CDD:394967	21/33 (64%)