Protein Alignment MEP1A and mep1a

DIOPT Version :10

• Sequence 1: XP_011512930.1
• Gene: MEP1A / 4224
• HGNCID: 7015
• Length: 774
• Species: Homo sapiens
• Sequence 2: NP_001015767.1
• Gene: mep1a / 548484
• XenbaseID: XB-GENE-921661
• Length: 704
• Species: Xenopus tropicalis
• Alignment Length: 725
• Identity: 427/725 - (58%)
• Similarity: 529/725 - (72%)
• Gaps: 49/725 - (6%)

Human    52 IKYLPEENVHDADFGE-QKDISEINLAAGLDLFQGDILL-QKSRNGLRDPNTRWTFPIPYILADN 114
            |.:.|::. ::||.|| ::||.:|||.:||:||:|||:| .::||.|.|...||:||||||||||
 Frog    24 INHRPKQG-NEADAGELREDIPQINLESGLNLFEGDIVLPPRARNALLDDYYRWSFPIPYILADN 87

Human   115 LGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKA 179
            |.||||..||.|||||||||||||||||||.:||.||:|.||||.|||..||||:|||:.|.|||
 Frog    88 LDLNAKSVILKAFEMFRLKSCVDFKPYEGEPTYIHFQKFGGCWSMVGDLKVGQNLSIGERCDYKA 152

Human   180 IIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQP 244
            |:||||||||||||||||:||||||.|||::|.||.:|||:.|:|:.||||||||||||:|||.|
 Frog   153 IVEHEILHALGFYHEQSRSDRDDYVKIWWEEITSGMEHNFNKYEDNYITDLNTPYDYESVMHYGP 217

Human   245 FSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQ 309
            .|||||..||||||||..||.|||||||||.|||||||||||||.:|||||.||||..|||||:|
 Frog   218 LSFNKNPDVPTITAKIEAFNDIIGQRLDFSEIDLERLNRMYNCTASHTLLDQCTFEYINICGMVQ 282

Human   310 GTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQF 374
            ||.|:.||.|:.| |.|..||||.|.|..|||||.|.|.||.....||||||||||||.:|||||
 Frog   283 GTNDNADWVHEMS-QPGSEDHTLAGGCRDAGYFMHFDTHSGPIGSTALLESRILYPKRSEQCLQF 346

Human   375 FYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGD 439
            ||||.||..||||:|::.||..|||||:.|:.|..||.|.:||||||.|...:||||:|||..|:
 Frog   347 FYKMDGSSQDRLVIWLKTDDGAGNVRKMRKLHTIYGDSDRSWKIAHVTLNANKKFRYVFQGIHGN 411

Human   440 PQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSR 504
            .:.| |||.||||:|||||||..||.|::||::||:|:|||::.|..||:.|||.:|:|:||:.:
 Frog   412 NKTS-GGISLDDISLTETPCPNTVWRVKDFSKILESTTKGDRIMSNPFYSPEGYAYGITIYPHGQ 475

Human   505 ESSGYLR---LAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAI 566
            .||.|:.   ::||:.|||:|.::|||..|||.|||:|||:|:|::|||||..|||..|....::
 Frog   476 ASSPYVNYTGISFHMISGEDDDVMEWPALNRQAIITVLDQDPNVQHRMSSSRSFTTLSSQIIESM 540

Human   567 NDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTE 631
            |:...|:|||.:||:...|:|:|:.|.|||.||||..|.||:||||||||:|::|||:|.||:||
 Frog   541 NNISRWERPSLIGTFDPTCDCYRTPDFGWSTFISHSQLHRRNFLKNDDLILFLEFEDLTFLSKTE 605

Human   632 VPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQ 696
            ||.:......:.::|:                              |.:||.:|.    |.|
 Frog   606 VPIRPAAPREKEVVLE------------------------------RSRRSPQNV----DEN--- 633

Human   697 YFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLT 761
                |||||||.|.|.||..||.|||||.|..||.|.||:||::|:||:||||:|||.||||.||
 Frog   634 ----PCDPNPCLNGGACVIEKGKASCRCASSQAFSYAGEQCQSMQMHGNVLGMLIGGGAGVIALT 694

Human   762 FSIIAILSQR 771
            .:|:||:|:|
 Frog   695 MAILAIISRR 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	166/230 (72%)
		MAM	292..459	CDD:214533	105/166 (63%)
		MATH_Meprin_Alpha	459..622	CDD:239752	85/165 (52%)
		EGF	702..736	CDD:394967	22/33 (67%)
mep1a	NP_001015767.1	ZnMc_meprin	31..260	CDD:239809	166/229 (72%)
		MAM	270..431	CDD:459878	102/162 (63%)
		MATH_Meprin_Alpha	430..596	CDD:239752	85/165 (52%)
		EGF	635..>658	CDD:394967	16/22 (73%)