DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MEP1A and tld

DIOPT Version :9

Sequence 1:XP_011512930.1 Gene:MEP1A / 4224 HGNCID:7015 Length:774 Species:Homo sapiens
Sequence 2:NP_524487.2 Gene:tld / 42945 FlyBaseID:FBgn0003719 Length:1067 Species:Drosophila melanogaster


Alignment Length:730 Identity:156/730 - (21%)
Similarity:254/730 - (34%) Gaps:236/730 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    89 LQKSRNGLRDPNTR-WTF-PIPYILADNLGLNAKGAIL-YAFEMFRLKSCVDFKPYEG--ESSYI 148
            :|:.|..:.....| |.: .|||.: |.:...|..|:. .|...:...:|:.|...:.  .::||
  Fly   131 IQRRRRAVTVRKERTWDYGVIPYEI-DTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYI 194

Human   149 IFQQFD-GCWSEVGDQHVG-QNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQI 211
            .|...: ||.|.:|....| |.||||:.|....||.||:.|.:||:||.:|.|||.::.|....|
  Fly   195 YFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNI 259

Human   212 LSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTIT-AKIPEFNSI-IGQRLDFS 274
            :.|.::|||......:.....|||..|:|||...||:|:..:.||| ..||....: :|||...|
  Fly   260 MRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLS 324

Human   275 AIDLERLNRMYNCTTT---------HTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDH 330
            ..|:.:.|.:|.|.:.         |.:..|..:....:....:|:.|    |.:|.:...|.|.
  Fly   325 RGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGD----AGEDPSAESEFDA 385

Human   331 TLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDS 395
            :|. .|.     .:.:.::|   |..:|..:.|:......|.|.:.::             ||  
  Fly   386 SLT-NCE-----WRITATNG---EKVILHLQQLHLMSSDDCTQDYLEI-------------RD-- 426

Human   396 TGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCP 460
             |...|...|:...|                               |.:|     ::..|:|   
  Fly   427 -GYWHKSPLVRRICG-------------------------------NVSG-----EVITTQT--- 451

Human   461 TGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGY--LRLAFH-VCSGEND 522
                     |::|.|                        |.|...:.||  .:..|. ||.|   
  Fly   452 ---------SRMLLN------------------------YVNRNAAKGYRGFKARFEVVCGG--- 480

Human   523 AILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNC 587
                                 |::.....|:                   |.|:....|..|..|
  Fly   481 ---------------------DLKLTKDQSI-------------------DSPNYPMDYMPDKEC 505

Human   588 FRSIDLGWSGFISHQM-LKRRSF-LKNDD--LIIFVDFEDITHLSQTEVPTK--GKRLSPQGLIL 646
            ...|    :...:||: ||.:|| |:..|  ...||:..|..| |.:.:..:  |.:|.|.   :
  Fly   506 VWRI----TAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNH-SDSRLIGRFCGDKLPPN---I 562

Human   647 QGQEQQ-----VSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNP 706
            :.:..|     ||:....|.....||.:.:.:.:             ..||.             
  Fly   563 KTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECK-------------FTDHG------------- 601

Human   707 CQNDGICVNVKGMASCRCISGHAFFYTGERCQ--------AVQVHGSV---------------LG 748
            ||:  :|:|..|...|.|.:|:.....|:.|:        |.:.:||:               :.
  Fly   602 CQH--LCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVW 664

Human   749 MVIGGTAGVIFLTFS 763
            .|:......:||.||
  Fly   665 EVVAPPNHAVFLNFS 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MEP1AXP_011512930.1 ZnMc_meprin 58..287 CDD:239809 68/206 (33%)
Astacin 101..289 CDD:279708 67/196 (34%)
MAM 292..459 CDD:214533 25/166 (15%)
MAM 297..459 CDD:99706 24/161 (15%)
MATH_Meprin_Alpha 459..622 CDD:239752 29/169 (17%)
EGF_CA 700..738 CDD:238011 9/37 (24%)
tldNP_524487.2 ZnMc_BMP1_TLD 137..338 CDD:239808 66/201 (33%)
Astacin 144..339 CDD:279708 67/195 (34%)
CUB 388..474 CDD:214483 24/182 (13%)
CUB 478..586 CDD:278839 30/158 (19%)
FXa_inhibition 595..630 CDD:291342 11/62 (18%)
CUB 634..750 CDD:278839 8/46 (17%)
FXa_inhibition 757..792 CDD:291342
CUB 797..906 CDD:278839
CUB 910..1023 CDD:278839
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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