DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MEP1A and CG15253

DIOPT Version :9

Sequence 1:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens
Sequence 2:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	83/223 - (37%)
Similarity:	113/223 - (50%)	Gaps:	12/223 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    76 LAAGLDLFQGDILLQ-KSRNGLRDPNTRWTFPIPYI-LADNLGLNAKGAILYAFEMFRLKSCVDF 138
            |.||  ..:||::.. .|||..|:...||...|.|. :...:....:..|:.|.:.....||:.|
  Fly    31 LTAG--YIEGDMVPSGSSRNIWRNETYRWPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTF 93

Human   139 KPYEGESSYI--IFQQFDGCWSEVG-----DQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQS 196
            |....:..|.  :..:..||:|.:|     .|...||..||.||.....|.||.||||||:|:||
  Fly    94 KEATTDQKYYVNVTSEEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQS 158

Human   197 RTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIP 261
            ..||||||.|..:.|..|.:.|||.|.:..:.|....|||.|:|||.|::|:||.. .||.|...
  Fly   159 AADRDDYVQIVEENITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKNGE-RTILALEE 222

Human   262 EFNSIIGQRLDFSAIDLERLNRMYNCTT 289
            ....:|||||:.|..|:.:||.:|.|.|
  Fly   223 GKEDVIGQRLELSETDIRKLNAIYKCPT 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	81/219 (37%)
		Astacin	101..289	CDD:279708	73/195 (37%)
		MAM	292..459	CDD:214533
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	73/195 (37%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	69/187 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41174
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910