Protein Alignment MEP1A and Mep1a

DIOPT Version :10

• Sequence 1: XP_011512930.1
• Gene: MEP1A / 4224
• HGNCID: 7015
• Length: 774
• Species: Homo sapiens
• Sequence 2: NP_037275.1
• Gene: Mep1a / 25684
• RGDID: 3080
• Length: 748
• Species: Rattus norvegicus
• Alignment Length: 779
• Identity: 569/779 - (73%)
• Similarity: 638/779 - (81%)
• Gaps: 36/779 - (4%)

Human     1 MAWIRSTCILFFTLLF-AHIAAVPVSRVLLFGYLEILILVYIIHFLYIYFFQIKYLPEENVH-DA 63
            |.|....|:|  :|.| ||||||                            .|::|...:.| |.
  Rat     1 MLWTLPVCLL--SLSFSAHIAAV----------------------------SIQHLSTGHDHDDV 35

Human    64 DFGE-QKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAF 127
            |.|| ||||||||.||||:||||||||.::||.||||::||..||||||||||.||||||||.||
  Rat    36 DVGEQQKDISEINSAAGLNLFQGDILLPRTRNALRDPSSRWKPPIPYILADNLDLNAKGAILNAF 100

Human   128 EMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFY 192
            ||||||||||||||||||||||||||.||||.|||||||||||||:||.|||||||||||||||:
  Rat   101 EMFRLKSCVDFKPYEGESSYIIFQQFSGCWSMVGDQHVGQNISIGEGCDYKAIIEHEILHALGFF 165

Human   193 HEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTIT 257
            ||||||||||||||||::|::.|:|||:||||..||||||||||||||||.|||||||.::||||
  Rat   166 HEQSRTDRDDYVNIWWNEIMTDYEHNFNTYDDKTITDLNTPYDYESLMHYGPFSFNKNETIPTIT 230

Human   258 AKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDS 322
            .||||||:||||||||||.||.|||||||||.||||||||.|||.||||||||||||.||.|:||
  Rat   231 TKIPEFNAIIGQRLDFSATDLTRLNRMYNCTRTHTLLDHCAFEKTNICGMIQGTRDDADWVHEDS 295

Human   323 AQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLV 387
            :|.|:|||||:|:|..|||||.|:||||...|.|||||||||||||||||||||||||||||||:
  Rat   296 SQPGQVDHTLVGRCKAAGYFMYFNTSSGVTGEVALLESRILYPKRKQQCLQFFYKMTGSPSDRLL 360

Human   388 VWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDI 452
            :||||||:|||||:|.|:||||||.|||||||||.|.||:||||:||||||||.||.||||||||
  Rat   361 IWVRRDDNTGNVRQLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFQGTKGDPGNSDGGIYLDDI 425

Human   453 TLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSR--ESSGYLRLAFH 515
            |||||||||||||:||.|||||||.|||:|.|||||||||||||||||||.|  .:||||.||||
  Rat   426 TLTETPCPTGVWTIRNISQVLENTVKGDRLVSPRFYNSEGYGFGVTLYPNGRITSNSGYLGLAFH 490

Human   516 VCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGT 580
            :.||:||.||||||||.|.|:||||||||.|||||.|::|||||..||.|||.:||||||::||.
  Rat   491 LYSGDNDVILEWPVENEQAIMTILDQEPDARNRMSLSLMFTTSKYQTSSAINGSVIWDRPTKVGV 555

Human   581 YHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLI 645
            |..||:||||||.||...||||||.||:|||:|.|||||||:|:|||.|||||...:.:.|:||:
  Rat   556 YDKDCDCFRSIDWGWGQAISHQMLMRRNFLKDDTLIIFVDFKDLTHLRQTEVPISSRSVIPRGLL 620

Human   646 LQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQND 710
            ||||| .::...|..||:||:||..|.|.||||.|||||||||:||||||||||||||||||||:
  Rat   621 LQGQE-PLALGDSRIAMMEESLPRRLDQRQPSRPKRSVENTGPMEDHNWPQYFRDPCDPNPCQNE 684

Human   711 GICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK 774
            |.||||||||||||:||||||||||||||:.||||:||::||....:|||||...:...|:.|:
  Rat   685 GTCVNVKGMASCRCVSGHAFFYTGERCQAMHVHGSLLGLLIGCITALIFLTFITFSNTYQKLRQ 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	189/230 (82%)
		MAM	292..459	CDD:214533	135/166 (81%)
		MATH_Meprin_Alpha	459..622	CDD:239752	123/164 (75%)
		EGF	702..736	CDD:394967	30/33 (91%)
Mep1a	NP_037275.1	ZnMc	32..260	CDD:469599	189/227 (83%)
		MAM	270..433	CDD:459878	131/162 (81%)
		MATH	432..596	CDD:445786	122/163 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	641..668		20/26 (77%)
		EGF	676..710	CDD:394967	30/33 (91%)