Protein Alignment CstF64 and RBM39

DIOPT Version :10

• Sequence 1: NP_477453.1
• Gene: CstF64 / 42239
• FlyBaseID: FBgn0027841
• Length: 419
• Species: Drosophila melanogaster
• Sequence 2: NP_909122.1
• Gene: RBM39 / 9584
• HGNCID: 15923
• Length: 530
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 53/208 - (25%)
• Similarity: 92/208 - (44%)
• Gaps: 29/208 - (13%)

  Fly     1 MADKAQEQSIMDKSMRSVFVGNIPYEATEEKLKEIFSEVGPVLSLKLVFDRESGKPKGFGFCEYK 65
            ||:..|:.|.  ..|| ::||::.:..||:.|:.||...|.:.|::|:.|.|:|:.||:||..:.
Human   238 MANNLQKGSA--GPMR-LYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFS 299

  Fly    66 DQETALSAMRNLNGYEIGGRTLRVDNACTEKSRMEMQQLLQGPQVENPYGEPCEPEDAPELITKT 130
            |.|.|..|:..|||:|:.||.::|.:.............|...::|                 :|
Human   300 DSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELE-----------------RT 347

  Fly   131 VASLPPEQMYELMKQMK----LCIVSNPSEARQMLMLNPQLAYALLQAMVVMRIVDPQQALGMLF 191
            ...|......:||.::.    |.|   |..|:|.|.::..||:..:.....  ::|.|..|....
Human   348 GIDLGTTGRLQLMARLAEGTGLQI---PPAAQQALQMSGSLAFGAVAEFSF--VIDLQTRLSQQT 407

  Fly   192 KANQMPPVLGGNP 204
            :|:.:.......|
Human   408 EASALAAAASVQP 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CstF64	NP_477453.1	RRM_CSTF2_CSTF2T	10..94	CDD:410072	30/83 (36%)
		CSTF2_hinge	111..190	CDD:433869	16/82 (20%)
		CSTF_C	377..416	CDD:464130
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146
		SF-CC1	46..518	CDD:273721	53/208 (25%)
		Interaction with JUN. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..406		32/136 (24%)
		Activating domain. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..355		19/80 (24%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250|UniProtKB:Q8VH51	355..406		13/55 (24%)
		Interaction with NCOA6. /evidence=ECO:0000250|UniProtKB:Q8VH51	406..530		2/15 (13%)