Protein Alignment CstF64 and HNRNPM

DIOPT Version :10

• Sequence 1: NP_477453.1
• Gene: CstF64 / 42239
• FlyBaseID: FBgn0027841
• Length: 419
• Species: Drosophila melanogaster
• Sequence 2: NP_005959.2
• Gene: HNRNPM / 4670
• HGNCID: 5046
• Length: 730
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 69/302 - (22%)
• Similarity: 121/302 - (40%)
• Gaps: 96/302 - (31%)

  Fly    19 FVGNIPYEATEEKLKEIFSE-VGPVLSLKLVFDRESGKPKGFGFCEYKDQETALSAMRNLNGYEI 82
            |:.|||::...:.||::..| ||.|..::|:.|.| ||.:|....|:|.:|:...|...||.:.:
Human    74 FITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAE-GKSRGCAVVEFKMEESMKKAAEVLNKHSL 137

  Fly    83 GGRTLRV-DNACTEKSRMEMQQLL--QGPQVENPYGEPCEPEDAPELITKTVASLPPEQMYELMK 144
            .||.|:| ::...|.:|..||:::  .|.....|.|        |.:||     :||.
Human   138 SGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGG--------PGMIT-----IPPS------- 182

  Fly   145 QMKLCIVSNPSEARQML---------------MLNPQLAYALLQ-----AMVVMRI--------- 180
                 |::||:...:::               .|:.::.:..|:     |.||:|.
Human   183 -----ILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGK 242

  Fly   181 ------------VDPQQALGMLFKANQMPPVLGGNPHQGPGNHTMMGQQQVPQQQVQIPQQQQQA 233
                        ::..||:.| |...    :|...|     .|..|.::.:|:.....|::.||.
Human   243 SRGIGTVTFEQSIEAVQAISM-FNGQ----LLFDRP-----MHVKMDERALPKGDFFPPERPQQL 297

  Fly   234 PQPPMPVPGPGFPANVHPNDIDLRMVPGGPMPMDPRMMGRGM 275
            |.      |.|        .|.:.:.||| .|:|...:.:|:
Human   298 PH------GLG--------GIGMGLGPGG-QPIDANHLNKGI 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CstF64	NP_477453.1	RRM_CSTF2_CSTF2T	10..94	CDD:410072	26/76 (34%)
		CSTF2_hinge	111..190	CDD:433869	18/119 (15%)
		CSTF_C	377..416	CDD:464130
HNRNPM	NP_005959.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		HnRNP_M_NLS	41..70	CDD:463289
		RRM1_hnRNPM	72..147	CDD:410058	26/73 (36%)
		RRM2_hnRNPM	204..279	CDD:410060	13/84 (15%)
		27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]	400..608
		RRM3_hnRNPM	654..730	CDD:410062