Protein Alignment CG31224 and FIZ1

DIOPT Version :10

• Sequence 1: NP_732361.1
• Gene: CG31224 / 42237
• FlyBaseID: FBgn0051224
• Length: 1784
• Species: Drosophila melanogaster
• Sequence 2: NP_116225.2
• Gene: FIZ1 / 84922
• HGNCID: 25917
• Length: 496
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 117/543 - (21%)
• Similarity: 169/543 - (31%)
• Gaps: 198/543 - (36%)

  Fly  1387 LDEKPTLPPLAMTTPAAKLAALYRMLIAYNESKLGQERNNLSELEQKAMEKSIFLCYVCRTDFPS 1451
            :|:.|...|    .||...||..|  :.::.|:.|:.....|:|.:
Human     1 MDDVPAPTP----APAPPAAAAPR--VPFHCSECGKSFRYRSDLRR------------------- 40

  Fly  1452 VKLYDAHLTEH----PAECFTCGKKFYRWKNFSLHLKRHLGWKEFGCYVCDKKFVVRSALVEHMR 1512
                  |...|    |..|..|||.|....|.:.||:.|.|.:.:.|..|.|.|...:.|:.|..
Human    41 ------HFARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQV 99

  Fly  1513 MHTGQTPLKCKICGKKFKRYSNLTQHRKRHTKMMVRKK--------------EYVCH------CG 1557
            :|||:.|..|.:|..:|...|:|.:|.||..:.::...              ...|:      ||
Human   100 VHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGVLPSPLQPGPGLPALSAPCSVCCNVGPCSVCG 164

  Fly  1558 -----------------------EVLPSKARFLWHKETHDLKPKCCPYCCDRFVHANSLRRHIRL 1599
                                   |...:.|.        .|.|..|..|..||.|...|..| ..
Human   165 GSGAGGGEGPEGAGAGLGSWGLAEAAAAAAA--------SLPPFACGACARRFDHGRELAAH-WA 220

  Fly  1600 AHSDKFDYAEPMECPMCKQIF-AKTSIKAHMATH------------------------------- 1632
            ||:|    .:|.:||.|::.| |...::.|..||
Human   221 AHTD----VKPFKCPRCERDFNAPALLERHKLTHDLQGPGAPPAQAWAAGPGAGPETAGEGTAAE 281

  Fly  1633 ----------------------------------------STEPQ----YDCAICSKSFSTKWNL 1653
                                                    :.||.    |.|. |...|::...|
Human   282 AGDAPLASDRRLLLGPAGGGVPKLGGLLPEGGGEAPAPAAAAEPSEDTLYQCD-CGTFFASAAAL 345

  Fly  1654 KIHSWVHANRTAKPFKCEYCPKAFVRELDFKNH-------------INAHKQIKP---------- 1695
            ..|...|:....  :.|.:|...:......:.|             ..|.::.:|
Human   346 ASHLEAHSGPAT--YGCGHCGALYAALAALEEHRRVSHGEGGGEEAATAAREREPASGEPPSGSG 408

  Fly  1696 -----YTCEYCGCKFIRKYNYMRHRREHHGTKKFTCDQCDKSFHRHYYLIEHRRMHTGERPFTCT 1755
                 :.|..|...|....:..||...|.|.|.|.|.:|.|.|....||..||.:|..||||.|.
Human   409 RGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGKFFRHECYLKRHRLLHGTERPFPCH 473

  Fly  1756 ICGKSSTTKTNHNKHLKIHHSRD 1778
            ||||...|.:|.::|||:|...|
Human   474 ICGKGFITLSNLSRHLKLHRGMD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31224	NP_732361.1	C2H2 Zn finger	1466..1486	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1494..1514	CDD:275368	6/19 (32%)
		zf-H2C2_2	1506..1531	CDD:463886	9/24 (38%)
		C2H2 Zn finger	1522..1542	CDD:275368	7/19 (37%)
		PHA00733	1527..1623	CDD:177301	29/139 (21%)
		C2H2 Zn finger	1554..1573	CDD:275370	5/47 (11%)
		C2H2 Zn finger	1580..1599	CDD:275368	7/18 (39%)
		C2H2 Zn finger	1613..1632	CDD:275368	6/19 (32%)
		COG5048	<1637..1780	CDD:227381	46/174 (26%)
		C2H2 Zn finger	1640..1660	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1670..1690	CDD:275368	3/32 (9%)
		C2H2 Zn finger	1698..1718	CDD:275368	5/19 (26%)
		zf-H2C2_2	1710..1733	CDD:463886	9/22 (41%)
		C2H2 Zn finger	1726..1746	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1754..1774	CDD:275368	10/19 (53%)
FIZ1	NP_116225.2	zf-C2H2	23..45	CDD:395048	5/46 (11%)
		C2H2 Zn finger	25..45	CDD:275368	5/44 (11%)
		zf-H2C2_2	37..62	CDD:463886	9/49 (18%)
		C2H2 Zn finger	53..73	CDD:275368	8/19 (42%)
		zf-H2C2_2	65..88	CDD:463886	8/22 (36%)
		C2H2 Zn finger	81..101	CDD:275368	6/19 (32%)
		C2H2 Zn finger	109..127	CDD:275368	6/17 (35%)
		C2H2 Zn finger	202..222	CDD:275370	7/20 (35%)
		C2H2 Zn finger	230..250	CDD:275370	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..280		1/29 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..412		2/33 (6%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..453	CDD:463886	10/24 (42%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-C2H2	470..492	CDD:395048	11/21 (52%)
		C2H2 Zn finger	472..492	CDD:275368	10/19 (53%)