DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31224 and Zfp579

DIOPT Version :9

Sequence 1:	NP_001287396.1	Gene:	CG31224 / 42237	FlyBaseID:	FBgn0051224	Length:	1784	Species:	Drosophila melanogaster
Sequence 2:	NP_081017.1	Gene:	Zfp579 / 68490	MGIID:	1915740	Length:	562	Species:	Mus musculus

Alignment Length:	392	Identity:	94/392 - (23%)
Similarity:	138/392 - (35%)	Gaps:	84/392 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1463 PAECFTCGKKFYRWKNFSLHLKRHLGWKEFGCYVCDKKFVVRSALVEHMRMHTGQTPLKCKICGK 1527
            |..|.|||:.|......|.|...|.|.:...|.:|.|.|...:.|..|:|.|..|.||:|..|.:
Mouse    45 PLPCPTCGRLFRFPYYLSRHRLSHSGLRPHACPLCPKAFRRPAHLSRHLRGHGPQPPLRCAACPR 109

  Fly  1528 KFKRYSNLTQH-RKRH--------TKMMVRKK---------EYVCHCGEVL----PSKARFLWHK 1570
            .|...:.|.:| .:.|        |:..|:::         |.|.....|:    ..:|...|
Mouse   110 TFPEPAQLRRHLAQEHAGSEVDLSTQRAVKEEPEASWGPQDEGVEQPATVVVAGAEEEATTQW-- 172

  Fly  1571 ETHDLKPKCCPYCCD--------RFVHANSLRRHIRLAHSDKFDYAEPME------CPMCKQIFA 1621
            ...|..|...|...|        ....|..||..:.||...:.:....::      |..|::.||
Mouse   173 PAGDSAPAAVPTSTDPRESEAKEAEAGAAELRAELALAAGRQEEKQVLLQADWTLLCLRCREAFA 237

  Fly  1622 -KTSIKAHMATHSTEPQ------------YDCAICSKSFSTKWNLKIHSWVHANRTAKPFKCEYC 1673
             |..:|||........|            :.|:||.|:|:..|:|..|..||:  |.:||.|..|
Mouse   238 TKGELKAHPCLRPEGEQEGEGGPPPRPKRHQCSICLKAFARPWSLSRHRLVHS--TDRPFVCPDC 300

  Fly  1674 PKAFVRELDFKNHINAHKQIK------------------------PYTCEYCGCKFIRKYNYMRH 1714
            ..||......:.|...|..:.                        |...|...|....:.....|
Mouse   301 GLAFRLASYLRQHRRVHGPLSLLAPLPGAGKKDDKASGGRNSGKGPEGGEGAECGGASEGGEGGH 365

  Fly  1715 R-------REHHGTKKFTCDQCDKSFHRHYYLIEHRRMHTGERPFTCTICGKSSTTKTNHNKHLK 1772
            .       |...|..:|.|.:|.|.|.|..:|.:|...|:|.|||.|..|.:......:..:|.:
Mouse   366 NGGDATPARPPAGEPRFWCPECGKGFRRRAHLRQHGVTHSGARPFQCVRCQREFKRLADLARHAQ 430

  Fly  1773 IH 1774
            :|
Mouse   431 VH 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31224	NP_001287396.1	C2H2 Zn finger	1466..1486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1494..1514	CDD:275368	7/19 (37%)
		zf-H2C2_2	1506..1531	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1522..1542	CDD:275368	5/20 (25%)
		PHA00733	1527..1623	CDD:177301	24/132 (18%)
		C2H2 Zn finger	1554..1573	CDD:275370	3/22 (14%)
		C2H2 Zn finger	1580..1599	CDD:275368	5/26 (19%)
		C2H2 Zn finger	1613..1632	CDD:275368	8/19 (42%)
		COG5048	<1637..1780	CDD:227381	43/181 (24%)
		C2H2 Zn finger	1640..1660	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1670..1690	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1698..1718	CDD:275368	4/26 (15%)
		zf-H2C2_2	1710..1735	CDD:290200	8/31 (26%)
		C2H2 Zn finger	1726..1746	CDD:275368	7/19 (37%)
		zf-H2C2_2	1738..1763	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1754..1774	CDD:275368	3/19 (16%)
Zfp579	NP_081017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		94/392 (24%)
		COG5048	45..>107	CDD:227381	22/61 (36%)
		C2H2 Zn finger	48..68	CDD:275368	7/19 (37%)
		zf-H2C2_2	60..85	CDD:372612	8/24 (33%)
		C2H2 Zn finger	76..96	CDD:275368	7/19 (37%)
		C2H2 Zn finger	104..121	CDD:275368	4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..154		5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..199		6/34 (18%)
		C2H2 Zn finger	229..251	CDD:275368	8/21 (38%)
		C2H2 Zn finger	269..289	CDD:275368	8/19 (42%)
		zf-C2H2	295..317	CDD:333835	6/21 (29%)
		C2H2 Zn finger	297..317	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..377		5/55 (9%)
		C2H2 Zn finger	384..404	CDD:275368	7/19 (37%)
		C2H2 Zn finger	412..432	CDD:275368	3/19 (16%)
		C2H2 Zn finger	441..461	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24383
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100