DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31224 and sprp-4

DIOPT Version :9

Sequence 1:	NP_001287396.1	Gene:	CG31224 / 42237	FlyBaseID:	FBgn0051224	Length:	1784	Species:	Drosophila melanogaster
Sequence 2:	NP_509499.1	Gene:	sprp-4 / 181132	WormBaseID:	WBGene00016189	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	1420	Identity:	254/1420 - (17%)
Similarity:	438/1420 - (30%)	Gaps:	556/1420 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 DDDEDDEDEEEEDEHDAPPEEEDGDDEREENSHSRNMSKTTKK-ARKTKPKRGSKRMSDEE---- 583
            :||..||:|||:|       |||.|.||...|..|..:|..:: ..:.||||...:.:.:|
Worm    36 EDDLSDEEEEEDD-------EEDDDFERSLTSAQRISTKVQEEVTEEVKPKRKYVKTNIKEPKPV 93

  Fly   584 -EFMSLSSGCESDLEKEGKQEQLNAAASLPPPLCTAPSTSAAAGASTSNLADNHSNSASNSASNS 647
             |.:.:....:       |:.:.|::|....|..|:|
Worm    94 PERVYVRGPYK-------KKNKPNSSAVFVQPQVTSP---------------------------- 123

  Fly   648 NSTATTKSKKNRITVL--SDVPLNMNEYLDLMGNIVASSRIGASRPFAAVAPIPLVKVEKEEPLD 710
                  |.::.||.::  ||..|:::                        ||..|::.|
Worm   124 ------KEQQKRIDIITESDAELSLD------------------------APPLLLQQE------ 152

  Fly   711 DYDNVAMAANEELE-QKPSLEHGTTSVIRMASTAAASTSATATETSAEDL----------TQPPP 764
                 |....:.:. .|.|.||.....||.::.....|:..| ||:.|.:          ..|||
Worm   153 -----AYLMQQSISGTKRSEEHTKDFGIRQSNRQRKPTAKLA-ETAQEVVPFMVYKNSPSPSPPP 211

  Fly   765 MKVEVEATTTLLPQRFSTPAQHRGPKKLV--------IKPKQTAPATATTTKKTDTPSSPSN--- 818
            |....:.|::........||..|...|.:        .:|..:....:|::.:|:|.:..||
Worm   212 MLEVQQPTSSETCSVVKGPALKRKYNKTIDDDMDFGHSRPCSSRSLASTSSDQTETGTRRSNRTV 276

  Fly   819 NPSI-----SRDLVQVKSETLEAPATSSSSSI----LEKHLTTSRKLLHHHSAVNDDDA------ 868
            .||:     |:..::::...||.|..|.|||:    |..::|.....:...|..:.||.
Worm   277 KPSLKKLESSQFQIEMEPLLLEIPTPSGSSSLPTSSLHSYVTKPCHSISRSSVDSVDDTIEAMKR 341

  Fly   869 RVLL--------EFA-------------NSKQPPPLAASS---------------TTFVVNASVG 897
            |:.|        .||             :|:||   :.||               .||:.|..|
Worm   342 RMTLMMDQNFDERFAKFLIPKKAQCTSPSSEQP---STSSYKLPRNLQQFEKMPVGTFLKNRGV- 402

  Fly   898 FPSAGSVFASSSTSC------SKAPAK-PGEEYILPDNNM-DVDEIVISSSSSYTSSAAQVQNTL 954
                .|:|.:||| |      ...||: |....:..|||: :|.::...:..|.:||.....|.
Worm   403 ----SSIFNTSST-CGAPTIDKMVPAELPSPVVLSEDNNIFEVKDVNAENDQSASSSKLGASNA- 461

  Fly   955 QPPDFNFLYHQATTTATTATYFNPFSRQQQHHHQQ---QHGVSDATNAATLASSSSNSLDHESM- 1015
               |...|..:...:...:.|.|  :::..:.:.|   ..|:|:..:..|  ..:..::|::..
Worm   462 ---DSVVLAGKIQLSVLLSKYEN--TKETDNLNVQSLISSGISETADMET--EETFETIDNDEQC 519

  Fly  1016 ----NATF------------------RVAKTQSLQSWYQQEPDHDPQNQGGAESGTVTPSNQSQD 1058
                ..||                  |:.:..|:::..:.|               || ...:.|
Worm   520 PVLERETFIIGEKDSAKIILPDEAVPRIVEEMSIKTVLEPE---------------VT-MEVTDD 568

  Fly  1059 VVSHQPTNFNAALAAVDCCSVALDEDAKYLDLDACKREQLSSSSNLPSASASTTSSSF-----AG 1118
            |.|.:..::              ..|.:..:.|..|.| |:...|.|....||:::..     |.
Worm   569 VFSMEQEDY--------------VNDIEMTNYDMIKSE-LNGPDNKPPCQISTSTAEAELPMQAM 618

  Fly  1119 AGTESSLVGGLNIRTDEKMPA-----KGEISEQESNCDIENSWSESVYGDISQRYFRNQFSGGYH 1178
            .....||...::|:.:...|.     :.|||.:::   :|.|..||.:|        |..:|
Worm   619 EDFHLSLKEDVDIKEESPSPKDNVADRHEISIEKT---LEESRKESSFG--------NSENG--- 669

  Fly  1179 PDWRQDYYPAQDLSAQLREHKRFDFNAVDDEASSSSRRSHLTDLPTAATSSACTSSAMLAGPPIA 1243
                                   :.:||.||....::..          :|.|::.   ....::
Worm   670 -----------------------EDSAVKDEQVKKTKNE----------NSQCSTG---TNDKMS 698

  Fly  1244 STSRAAAEAAAEAAALAQRKPQRRKLYKCPHCEAIFEKLKERNAHMIGEHNYVRQNRRLICTQPQ 1308
            :|.:.:..||..::|:                                              .||
Worm   699 TTQKESTPAAPISSAV----------------------------------------------PPQ 717

  Fly  1309 INTSMLTLQQQMIVQSGEVEDSKDGIVKIKQEQCQEKQDVEQMHDHSELLADVKDSELMGIGGDG 1373
                             ||.:.|.|      ::|...:       ||..:..:.
Worm   718 -----------------EVTEEKKG------QECVPLR-------HSSRIQKLN----------- 741

  Fly  1374 DGDVDDDIKPPNQLDEK--PTLPPLAMTTPAAKLAALYRMLIAYNESKLGQERNNLSELEQKAME 1436
                    :.|:...||  ...||.:.:.|:               |...|:..|..:     ..
Worm   742 --------QKPSYFQEKIVSNQPPGSSSIPS---------------SNSSQDNENTEK-----FA 778

  Fly  1437 KSIFLCYVCRTDFPSVKLYDAHLTEHPAECFTCGKKFYRWKNFSLHLKRH----LGWKEFGCYVC 1497
            .:|.:.|     |...|:......|....|..|..|........||...|    |..:.|.|..|
Worm   779 SNIDVLY-----FQMRKVLGRGFPERNYRCLECSFKTSDCDAMQLHTYYHKSSKLEDRNFQCSEC 838

  Fly  1498 DKKFVVRSALVEHMRMH----TGQTPLKCKICGKKFKRYSNLTQHR-------------KRHTKM 1545
            .......|.:.:|:|:|    |....:|..   .|..|...:.:.|             ||..|.
Worm   839 TFNVNSASCMTQHLRIHNIDVTDDNVVKAY---AKHVRQQKIEEGRARMALLNRLNAAIKRPIKE 900

  Fly  1546 MVRKKEYVCHCGEVLPSKARFLWHKETHDLKP-------KC--CPYCCDRFVHANSLRRHIRLAH 1601
            .||:|..:     .:.|||     |..|..|.       :|  |.:.|   ...|:     ...|
Worm   901 PVREKNKL-----PMSSKA-----KAAHRSKQFSSTVEFRCDKCDFKC---ASVNN-----SFEH 947

  Fly  1602 SDKFDYAEPMECPMC------KQIFAKTSIKAHMATHSTEPQYDCAICSKSFSTKWNLK---IHS 1657
            ||:..:.:...|.:|      |::......|.|...|.|       :.:...:...|::   |..
Worm   948 SDRHGWNKLYRCKLCDYSDDTKEVVGFHETKHHNIDHLT-------LANVVRNISCNMRNGFIQP 1005

  Fly  1658 WVHANRTAKPF-----------KCEYCPKAFVRELDFKNHI----NAHKQIKPYTCEYCGCKFIR 1707
            .::.|:|...:           ||.:|        ::..|:    ..|.|
Worm  1006 SLNGNQTPTSYKIAQRSGGALIKCSFC--------EYHTHVASEMGLHMQ--------------- 1047

  Fly  1708 KYNYMRHRREHHGTKKFTCDQCDKSFHRHYYLIEHRRMHTGERPFTCTICGKSST 1762
                ..||:| .|.|:...|                 ::.|..|...||...|:|
Worm  1048 ----NNHRKE-TGAKEVISD-----------------LYMGIMPKNSTIISVSTT 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31224	NP_001287396.1	C2H2 Zn finger	1466..1486	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1494..1514	CDD:275368	5/19 (26%)
		zf-H2C2_2	1506..1531	CDD:290200	6/28 (21%)
		C2H2 Zn finger	1522..1542	CDD:275368	4/32 (13%)
		PHA00733	1527..1623	CDD:177301	25/123 (20%)
		C2H2 Zn finger	1554..1573	CDD:275370	4/18 (22%)
		C2H2 Zn finger	1580..1599	CDD:275368	3/18 (17%)
		C2H2 Zn finger	1613..1632	CDD:275368	5/24 (21%)
		COG5048	<1637..1780	CDD:227381	22/144 (15%)
		C2H2 Zn finger	1640..1660	CDD:275368	2/22 (9%)
		C2H2 Zn finger	1670..1690	CDD:275368	3/23 (13%)
		C2H2 Zn finger	1698..1718	CDD:275368	2/19 (11%)
		zf-H2C2_2	1710..1735	CDD:290200	6/24 (25%)
		C2H2 Zn finger	1726..1746	CDD:275368	1/19 (5%)
		zf-H2C2_2	1738..1763	CDD:290200	6/25 (24%)
		C2H2 Zn finger	1754..1774	CDD:275368	4/9 (44%)
sprp-4	NP_509499.1	COG5665	<557..>746	CDD:227952	50/364 (14%)
		C2H2 Zn finger	803..819	CDD:275368	3/15 (20%)
		C2H2 Zn finger	835..855	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I3725
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050