DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and Tdrd1

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	XP_006527536.1	Gene:	Tdrd1 / 83561	MGIID:	1933218	Length:	1173	Species:	Mus musculus

Alignment Length:	1171	Identity:	262/1171 - (22%)
Similarity:	416/1171 - (35%)	Gaps:	310/1171 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SANQSLSPSSISEIVQTVKCSECGNATASGECRQCNAFYCRRCFDAVHKRSRVLKSHIFR----- 181
            |.|.....:|:...:::..|..|| ...|..|.||...|  .|..|..:|.....|.|.|
Mouse   144 SVNNPALFNSLGPPLRSTTCHRCG-LFGSLRCSQCKQTY--YCSTACQRRDWSSHSTICRPVQQS 205

  Fly   182 -NSTEQDSS-------------------FSKKLRVGDQ---YFTLPSQNLCIHHRMPKDKYCMKC 223
             |..|.:.|                   .:|::..|.:   :..|.|..|
Mouse   206 LNKLEDNKSPFETKAIEVKSEQVDCPPGVTKEITAGAERVMFSDLRSLQL--------------- 255

  Fly   224 YRSHCQICSTVHHSGHRIRKLIEINQSYASEIPTTLNSLNMAHIHVLNGKQVVQRAKQKLNDYAT 288
             :...:|..||....|.....|::   |:||:...:|.|:.:                     ..
Mouse   256 -KKTMEIKGTVTEFKHPSNFYIQL---YSSEVLENMNQLSTS---------------------LK 295

  Fly   289 ETLASISKRFSHL--HGLLQVAELQVIEKLRESSLPPQLKLNEAMGQLSGYETVIERLTKSLNSG 351
            ||.|::.....:|  .|.:.||:..|.:           ..|.|:.|.   ..|::|....|...
Mouse   296 ETYANVVPEDGYLPVKGEVCVAKYTVDQ-----------TWNRAIVQA---VDVLQRKAHVLYID 346

  Fly   352 VGNDMAVPRDVSLRWLLK---------LICEHLEKIPTTVQ-----VSKVDENPYRVTCS-RFMD 401
            .||:..:|.| |:..|.:         :.|.....|||..:     |:.|....:...|| :.||
Mouse   347 YGNEEMIPID-SVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFCSVKVMD 410

  Fly   402 ISNIFKCEFVNPNIQVCFKTDLEISRSLSSSPKGEITFLTSSSSSKENFDPHSRKLLLAQNSKLK 466
            |        :...:..| ..||.:                  .||.:..|    .:|:.....:|
Mouse   411 I--------LEEEVLTC-AVDLVL------------------QSSGKQLD----HVLVEMGYGVK 444

  Fly   467 KATQVSQSQKKRGKNATEVAQSSLNSTAAIIDEFPAKDLDFLHNFSSLDITKRNK-----TTEDS 526
            ...|.|..|        .|..|:|.....:..|             |..:|.||.     .|.:.
Mouse   445 PGEQSSTEQ--------SVDHSALEDVGRVTVE-------------SKIVTDRNALIPKVLTLNV 488

  Fly   527 SDWFKTDTLVRVRSVQSPEDFYVQGI---HAAQRLREELDTFAHTLSDSSSVPPTIVVGQNYIIH 588
            .|.|    ...|..:|:||||:.|.:   |....|:|.|..:...:...|...|||  |......
Mouse   489 GDEF----CGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTI--GDVCCAQ 547

  Fly   589 HKDKDRYYRALVSQKLTNENLYNVFLTDIG----VHLHVRCSDFRVVPERISHLPYSAVHCSLSE 649
            ..:.|::|||.|....:.|::. |...|.|    :.|...|.   ::| ::..||..|::|.|:.
Mouse   548 FSEDDQWYRASVLAYASEESVL-VGYVDYGNFEILSLKRLCP---IIP-KLLDLPMQALNCVLAG 607

  Fly   650 LMPKNGESEWDSKASAFLKQIVQNNPVRVIVKKAL-TYELHGVDLITSNYDTNISVRDSFLYCGL 713
            :.|..|  .|..:|...:|::|||..|.|.|...| |..|  |:||..:...::|...:.:..|.
Mouse   608 VKPSLG--IWTPEAVCVMKEMVQNRMVTVRVVGMLGTRAL--VELIDKSVAPHVSASKALIDSGF 668

  Fly   714 AISR-----DGAPLWLPPAPTALRLPR-------ISFRFGDVYMVQMLHVEDPQEFYVMRHDYEK 766
            ||..     .|:.:.....|.|:..|.       :.|...:...|.:..:..|.|||.  |
Mouse   669 AIKEKDVADKGSSMHTASVPLAIEGPAEALEWTWVEFTVDETVDVVVCMMYSPGEFYC--H---- 727

  Fly   767 KRLWLQFSLQEAMDRINIS-------QLQNIFLGQLHLGC--VLQSGGQWKRASIEQILPDGYVL 822
               :|:....|.:|.:|.|       :..|.|..::...|  .....|.|.||.:::|||.|.|.
Mouse   728 ---FLKDDALEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVK 789

  Fly   823 VHLVDEGPSQKVFWDQL-FVLPQKFWDTGLAIKCCLADVETRAEHSYTWTPEGTTLFKQLTSNPR 886
            ||.||.|..::|..||| .:|||........::|.|.|::...:|   ||.|.|..|:......:
Mouse   790 VHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKH---WTKEATARFQACVVGLK 851

  Fly   887 LYMDVISCTE-----DLVYVSLHFERSNSETTSVGVQLVAHGHCTSSGESSRMITPTVSNRSVRF 946
            |...|:..|.     :|..:|..:.:..|:.. :..|||.  .| .|.:.|.|..|  :|:..:.
Mouse   852 LQARVVEITANGVGVELTDLSTPYPKIISDVL-IREQLVL--RC-GSPQDSLMSRP--ANQHKQI 910

  Fly   947 DEETKKFIAQQKVRPVELSPYRMPDNTER---NKRTTVNILYVRKPDEFYVTLPHFQKAINNLQK 1008
            |...           |:.||......|..   ||....|:|.:..|..|| .:|  .:...|.:|
Mouse   911 DSHR-----------VQASPSAEQWKTMELPVNKTIAANVLEIISPALFY-AIP--SEMSENQEK 961

  Fly  1009 ------------SVQKAAAAMYQNMLPRTDWQVGDMCYARVQANCDSQALWYRGVVTGVIPPGIT 1061
                        :.||...| |:   |||    ||.|.|: ..|.|   .|||.:|.......:
Mouse   962 LCVLAAELLEHCNAQKGQPA-YR---PRT----GDACCAK-YTNDD---FWYRAIVLETSESDV- 1013

  Fly  1062 CPIVRYQVHLRDLGELIDDVHSSSLANIDEADMRISSSAKRCHLHGIRPIGDEWSKDAIDFFMD- 1125
                  :|...|.|. |:.:..|.:..|..:.:.:.....||.|.|...:....|:..::...:
Mouse  1014 ------KVLYADYGN-IETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELLRNA 1071

  Fly  1126 --------QLKAYNE-IH-VTGRGRTENSLSVILWGSLSILTGPFSPATIKYVNINKALLMAGMA 1180
                    .:||.:: :| |:....:||.:                      :||.:.|:|.|:|
Mouse  1072 MLNQSVVLSVKAISKNVHAVSVEKCSENGM----------------------INIAENLVMCGLA 1114

  Fly  1181 E 1181
            |
Mouse  1115 E 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662	11/34 (32%)
		TUDOR	536..648	CDD:278965	32/118 (27%)
		TUDOR	741..859	CDD:278965	37/127 (29%)
		TUDOR	<805..839	CDD:119391	16/33 (48%)
		TUDOR	981..1107	CDD:278965	34/137 (25%)
		TUDOR	1296..1403	CDD:278965
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
Tdrd1	XP_006527536.1	zf-MYND	163..199	CDD:366792	12/38 (32%)
		TUDOR	262..378	CDD:366171	30/154 (19%)
		TUDOR	493..606	CDD:366171	32/119 (27%)
		TUDOR	718..825	CDD:366171	35/115 (30%)
		TUDOR	936..1050	CDD:366171	33/136 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8300
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007887
OrthoInspector	1	1.000	-	-		otm43916
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.760