DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and TDRD1

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_001372292.1	Gene:	TDRD1 / 56165	HGNCID:	11712	Length:	1189	Species:	Homo sapiens

Alignment Length:	1296	Identity:	282/1296 - (21%)
Similarity:	484/1296 - (37%)	Gaps:	326/1296 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 ESSLPPQLKLNEAMGQLSGYETVIERLTKSLNSGVGNDMAVPRDVSLRWLLKLICEHLEKIPTTV 382
            |:.|||...| .:.|.|..:...  ||..|.|....|:.             |:||..::...:.
Human    32 ENKLPPHESL-RSPGTLPNHPNF--RLKSSENGNKKNNF-------------LLCEQTKQYLASQ 80

  Fly   383 QVSKVDENPYRVTCSRFMDISNIFKCEFVNPNIQVCFKTD---LEISRSLSSSPKGEITFLTSSS 444
            :.:.|..||                 ..:|..: |..|.|   |....|: |.|..|     |:|
Human    81 EDNSVSSNP-----------------NGINGEV-VGSKGDRKKLPAGNSV-SPPSAE-----SNS 121

  Fly   445 SSKE-NFDPHSRKLLLAQNSKLKKATQVSQSQKKRG----------------------KNATEVA 486
            ..|| |..| ...:..|::.||.|..:.|.|....|                      ...::..
Human   122 PPKEVNIKP-GNNVRPAKSKKLNKLVENSLSISNPGLFTSLGPPLRSTTCHRCGLFGSLRCSQCK 185

  Fly   487 QSSLNSTAAIIDEFPAKDL-------DF--LHNFSSL---DITKRNKT------TEDSSDWFKTD 533
            |:...|||....::.|..:       :|  |.|.||:   |:...||:      |::.:.|.:..
Human   186 QTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETKDVEVNNKSDCPLGVTKEIAIWAERI 250

  Fly   534 TLVRVRSVQ---------------SPEDFYVQGIHAAQ------RLREEL-DTFAHTLSDSSSVP 576
            ....:||:|               .|.||||| :::::      :|...| :|:|: :.:...:|
Human   251 MFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQ-LYSSEVLEYMNQLSASLKETYAN-VHEKDYIP 313

  Fly   577 PTIVVGQNYIIHHKDKDRYYRALVSQKLTNENLYNVFLTDIGVHLHVRCSDFRVVP-ERISHL-- 638
               |.|:..|..:.....:.||::......:...:|...|.|        :..::| .||.||
Human   314 ---VKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYG--------NEEIIPLNRIYHLNR 367

  Fly   639 -----PYSAVHCSLSELMPKNGESEWDS---KAS--AFLKQIVQNNPVRVIVKKALTYELHGVD- 692
                 |..|:.|.::.::|  .|..|.|   ||:  ..::|......|.::.::.:|:.:. |:
Human   368 NIDLFPPCAIKCFVANVIP--AEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEVVTFAVE-VEL 429

  Fly   693 ----------LITSNYDTNISVRDSFLYCGLAISRDGAPLWLPPAPTALR------------LPR 735
                      ||...|....|.:||        .::.|....|.....:.            :|:
Human   430 PNSGKLLDHVLIEMGYGLKPSGQDS--------KKENADQSDPEDVGKMTTENNIVVDKSDLIPK 486

  Fly   736 I-SFRFGDVYMVQMLHVEDPQEFYVMRHDYEKKRLWLQFSLQEAMDRINISQLQNIFLGQLHLGC 799
            : :...||.:...:.|::.|::|:..:....:|...||.||.:..|::.........:|.:   |
Human   487 VLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDI---C 548

  Fly   800 VLQ--SGGQWKRASIEQILPDGYVLVHLVDEGPSQKVFWDQLFVLPQKFWDTGL-AIKCCLADVE 861
            ..|  ...||.|||:.....:..|||..||.|..:.:...:|..:..|..:..: ||||.||.|:
Human   549 CAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVK 613

  Fly   862 TRAEHSYTWTPEGTTLFKQLTSNPRLYMDVISCTEDLVYVSLHFERSNSETTSVGVQLVAHGHCT 926
            ....   .||||...|.|:|..|..:.:.|:...|:...|.| .::|.:...||...|:..|...
Human   614 PSLG---IWTPEAICLMKKLVQNKIITVKVVDKLENSSLVEL-IDKSETPHVSVSKVLLDAGFAV 674

  Fly   927 SSGESSRMITPTVSNRSVRFDEETKKFIAQQKVRPVELSPYRMPDNTERNKRTTVNILYVRKPDE 991
              ||.| |:|...|:    ..|.:.....:.||.|:|.:...:  ..::.....|.::|  .|.|
Human   675 --GEQS-MVTDKPSD----VKETSVPLGVEGKVNPLEWTWVEL--GVDQTVDVVVCVIY--SPGE 728

  Fly   992 FY--VTLPHFQKAINNLQKSVQKAAAAMYQNMLPR-TDWQVGDMCYARVQANCDSQALWYRGVVT 1053
            ||  |......|.:|:|.||:    |...|..||. ...::|..|.|....:    ..|||.:|.
Human   729 FYCHVLKEDALKKLNDLNKSL----AEHCQQKLPNGFKAEIGQPCCAFFAGD----GSWYRALVK 785

  Fly  1054 GVIPPGITCPIVRYQVHLRDLGELIDDVHSSSLANIDEADMRISSSAKRCHLHGIRPIGDEWSKD 1118
            .::|.|      ..:||..|.|. |::|.:..|..|....:.:.....||.|..|:.....||::
Human   786 EILPNG------HVKVHFVDYGN-IEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEE 843

  Fly  1119 AIDFFMDQLKAYNEIHVTG---RGR----TENSLSVILWGSLSILTGPFSPATIKYVNINKALLM 1176
            ||..|        ::.|.|   :.|    |||.:.|    .|:.|:..: |..|..|.|::.|::
Human   844 AITRF--------QMCVAGIKLQARVVEVTENGIGV----ELTDLSTCY-PRIISDVLIDEHLVL 895

  Fly  1177 AGMAEKDHNSDSEDDQQSMPENVSVNSEE----------AAKANDWESCLSKIDGTSKTNDSLNL 1231
                      .|....:.:|.:..||..|          .:.|..|::....:|.|.:.    |:
Human   896 ----------KSASPHKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQA----NV 946

  Fly  1232 IESRSVTVGFEHNEDMPPLALLEDLGNTKNTTGETTPPAGWTTRRKCDKSVFTAIATNVTYECCI 1296
            :|..|..:.:...:.||.                       ...:.|          .:|.|...
Human   947 LEIISPNLFYALPKGMPE-----------------------NQEKLC----------MLTAELLE 978

  Fly  1297 YLTLASDKPFIEHMGNLLVREYKPLMDKQKERSTSYTYKVGQAVVVTYHMDNMIYRGIVQRLENN 1361
            |......:|           .|:|              ::|.|....|..|:..||.:|  |..:
Human   979 YCNAPKSRP-----------PYRP--------------RIGDACCAKYTSDDFWYRAVV--LGTS 1016

  Fly  1362 HNEYTVYYVDYGNMELVKADEMLPYA------PFPDLN-AMCFLVELHGVRSKQGKYSLKEMDTV 1419
            ..:..|.|.||||:|.:....:.|..      ||..:. ::..|:||:|..|:.....||.. .:
Human  1017 DTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNF-ML 1080

  Fly  1420 HLNLVMKLSGVRIVDDETVGPNKIPKCQIKVGNVDIATMMIDSGMSVPI--EKQTIKNNTK 1478
            :.|:::.:.|:    .:.|....:.||. :.|.||:|..::..|::..|  ::|:..|..|
Human  1081 NQNVMLSVKGI----TKNVHTVSVEKCS-ENGTVDVADKLVTFGLAKNITPQRQSALNTEK 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	30/141 (21%)
		TUDOR	741..859	CDD:278965	32/120 (27%)
		TUDOR	<805..839	CDD:119391	11/33 (33%)
		TUDOR	981..1107	CDD:278965	36/128 (28%)
		TUDOR	1296..1403	CDD:278965	25/113 (22%)
		TUDOR	1337..1385	CDD:119391	15/47 (32%)
		TUDOR	1710..1761	CDD:119391
TDRD1	NP_001372292.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..138		18/83 (22%)
		zf-MYND	170..206	CDD:396356	5/35 (14%)
		Tudor_TDRD1_rpt1	268..396	CDD:410479	31/142 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..469		5/26 (19%)
		Tudor_TDRD1_rpt2	517..598	CDD:410480	22/83 (27%)
		TUDOR	715..832	CDD:395449	36/133 (27%)
		Tudor_TDRD1_rpt4	944..1059	CDD:410482	30/178 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8300
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007887
OrthoInspector	1	1.000	-	-		otm41866
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760