DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and tdrd1

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	XP_021335784.1	Gene:	tdrd1 / 553522	ZFINID:	ZDB-GENE-070803-1	Length:	1201	Species:	Danio rerio

Alignment Length:	1224	Identity:	234/1224 - (19%)
Similarity:	420/1224 - (34%)	Gaps:	296/1224 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 NSKLKKATQVSQSQKKRGKNATEVAQSSLNSTAAIIDEFPAKDLDFLHNFSSLDITKR--NKTTE 524
            :.|.|::..|..:....|..|.|::          :|..|.:       ....|:.|:  :|.:|
Zfish   128 SEKPKESKAVPYANGLGGTQAKEIS----------VDAQPKR-------IYRRDLHKKVVSKGSE 175

  Fly   525 DSSDWFKTDTLVRVRSVQS-PEDFYVQG------------IHA-AQRLREELDTFAHTL------ 569
            ....:|:..:||...|:.: |....:||            ||. .:.:.|.|......|
Zfish   176 IKVLFFRCSSLVCYPSIDTLPHTKCLQGTVIDLRNPGMFSIHCQCEEMIESLKKITQQLQKTYCS 240

  Fly   570 SDSSSVPPTIVVGQNYIIHHKDKDRYYRALVSQKLTNENLYNVFLTDIGVHLHVRCSDFRVVPER 634
            |.:....|.  ||:...:.......:|||.:...........||..|.|...:|.....|.:.|.
Zfish   241 SFAQEYKPE--VGELCAVKFSLDQNWYRAEIQAVDVARKTAGVFYIDFGNEENVALDHIRPLSEN 303

  Fly   635 ISHLPYSAVHCSLSELMPKNGESEWDSKASAFLKQIVQNNPVRVIVKKALTY---------ELHG 690
            |..:|..|:.|.::.:.|..|  .|..:....::|:        |..|:||:         :|..
Zfish   304 IDAVPPFALQCCIAGVKPLTG--SWTGECCIAVRQL--------IAGKSLTFTVLDIMNDGDLLA 358

  Fly   691 VDLITSNYDTNISVRDSFLYCGLAISRDGAPLWLPPAPTALRLPRISF----RF----------- 740
            ||.:.|....::|   :||.......::..|:......:...|...||    ||
Zfish   359 VDSLVSTLGKHVS---TFLIDQSYAIKEDVPVKTQTEHSINSLLTASFENFKRFSGGKNENSEAR 420

  Fly   741 ---------GDVYMVQMLHVEDPQEFYVMRHDYEKKRLWLQFSLQEAMDRINISQLQNIFLGQLH 796
                     ||.:...:.|::.|.|  ::....|...:..|..:...:...|.:...:.......
Zfish   421 PPEPLTQGVGDSFTAVVTHLQSPSE--ILCQKLENASIIQQLQMNLRVHCSNTAASDDFRPAPGT 483

  Fly   797 LGCVLQS-GGQWKRASIEQILPDGYVLVHLVDEGPSQKVFWDQLFVLPQKFWDTGL-AIKCCLAD 859
            :.|.|.| ..||.||.:.....:..|.|..:|.|.|::|..::|..:.::...... ||.|.||.
Zfish   484 VCCSLFSEDNQWYRAKVLAYSSEDRVCVGYIDFGNSEEVELNRLRPISKELLALATQAIPCSLAG 548

  Fly   860 VETRAEHSYTWTPEGTTLFKQLTSNPRLYMDVISCTEDLVYVSLHFERSNSETTSVGVQLVAHGH 924
            :::..:   ||:.|...:.|.|..|..:.::::...:....||: .:.|:....||...||..|.
Zfish   549 IKSLTD---TWSDEAVLMLKHLVCNRFIRVEILGKKDGRALVSM-IDESSDPQASVTELLVNMGF 609

  Fly   925 CTSSGESSRMITPTVSNRSVRFDEETKKFI---AQQKVRPVELSPYRMPDNTERNKRTTVNILYV 986
            .......::...|         |..|...|   :|..|..:|.:...:|.:   .::..:.|..:
Zfish   610 AAIESVETKKNEP---------DPATSTEIPPLSQPVVEKLEWTGAELPFD---GQKVELVISTL 662

  Fly   987 RKPDEFYVTLPHFQKAINNLQKSVQKAAAAMYQNMLPRTDWQ-------VGDMCYARVQANCDSQ 1044
            :..||||         ..|..|:.:.....|...::...:.:       ||:.|.|....:
Zfish   663 KSLDEFY---------CYNYSKTDEHTLTEMSFELMKHCESERAPFTPIVGEPCCALFTGD---- 714

  Fly  1045 ALWYRGVVTGVIPPGITCPIVRYQVHLRDLGELIDDVHSSSLANIDEADMRISSSAKRCHLHGIR 1109
            |.|||.:|..|...|      :.:|...|.|... :|.::.|..|.::.:::...|.||.|.|:.
Zfish   715 ARWYRAMVLEVCGEG------KARVCFVDYGNSC-EVDAAHLKAITQSLLKLPFQAIRCWLAGVE 772

  Fly  1110 PIGDEWSKDAIDFFMDQLKAYNEIHVTGRGRTENSLSVILWGSLSILTGPFSPATIKYVNINKAL 1174
            |:..:|.|:|:..|.                             ::..|  .|.:.|.::|
Zfish   773 PVEGQWKKEAMLRFQ-----------------------------ALCAG--QPLSGKVLSI---- 802

  Fly  1175 LMAGMAEKDHNSDSEDDQQSM------------------PENVSVNSEEAAKANDWESCLSKIDG 1221
                 .||.:..:.|...|::                  |..:. .::.|::..|..| |..||.
Zfish   803 -----TEKGYGMELESAGQTVASVLISEHLAKPYGQVRQPPQIQ-PAKPASQIEDLPS-LKPIDQ 860

  Fly  1222 TSKTNDSLNLIESRSVTVGFEHNEDMPPLALLEDLGNTKNTTGETTPPAGWTTRRKCDKSVFTAI 1286
            .....:.|.:....:.|.    .||:|              ......|..|.|         ..:
Zfish   861 NPSVEEPLKVSSKGAATT----PEDLP--------------VSSGCFPLNWKT---------LEL 898

  Fly  1287 ATNVTYECCIYLTLASDKPFIEHMGNLLVREYKPLM-------DKQKERSTSYTYKVGQAVVVTY 1344
            :.:.|::..:...::....:|.:.|.:.|...|.:|       .||...:..:... |.:....:
Zfish   899 SCSGTFQPRVAAVISPSLFYIMNPGQVNVEGLKAVMTDVAKYCSKQPVPNQCHPLP-GASCCAQF 962

  Fly  1345 HMDNMIYRGIVQRLENNHNEYTVYYVDYGNMELVKADEMLPYA------PFPDLNAMCFL----- 1398
            ..|...||.:|..:...|..  |.|.||||||.|....:||..      ||..:.  |.|
Zfish   963 SGDKNWYRAVVLEVTTKHAH--VIYSDYGNMETVPLSSILPITKELLQHPFQIVR--CALTGKEH 1023

  Fly  1399 ---------VELHGVRSKQGKY-SLKEMD-TVHLNLVMKLSGVRIVDDETVGPNKIPKCQIK--- 1449
                     :||.|::...|.. |.:..| |.:|..:.:.||....|..::....:.|.|||
Zfish  1024 FPVVWPTEVLELFGIQLSGGVLASFQGFDGTSNLLTLTQQSGQSDRDINSIILGALQKGQIKPSS 1088

  Fly  1450 --VGNVDIATMMIDSGMSVPIE-----KQTIKNNTKYLPSQKFLEDFKVFDELDHLAAGEGELSD 1507
              ..||:.....::...:.||.     :||:..|.:                       :..|.|
Zfish  1089 KLPANVNEEKKDVEQKQTQPISSNKAVEQTLSTNVE-----------------------KPALDD 1130

  Fly  1508 KEAP-PTQRKHDSISSVQQPPTKKFLVDQEE----VEAFECDQDFDCQQAAQKM 1556
            :..| ....||:...::.:..|.:......:    :|:....|...||:..|||
Zfish  1131 QTLPLSVSLKHEEPENMSKTKTAEECTSTPDTVSSIESSHAAQSCCCQELKQKM 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	28/131 (21%)
		TUDOR	741..859	CDD:278965	26/119 (22%)
		TUDOR	<805..839	CDD:119391	10/33 (30%)
		TUDOR	981..1107	CDD:278965	29/132 (22%)
		TUDOR	1296..1403	CDD:278965	30/133 (23%)
		TUDOR	1337..1385	CDD:119391	15/47 (32%)
		TUDOR	1710..1761	CDD:119391
tdrd1	XP_021335784.1	zf-MYND	83..119	CDD:307734
		TUDOR	210..318	CDD:306940	23/109 (21%)
		TUDOR	429..548	CDD:306940	26/120 (22%)
		TUDOR	652..770	CDD:306940	29/137 (21%)
		TUDOR	908..1020	CDD:306940	28/116 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007887
OrthoInspector	1	1.000	-	-		otm25033
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810