DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and tapas

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	1394	Identity:	232/1394 - (16%)
Similarity:	440/1394 - (31%)	Gaps:	484/1394 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 ICEHLEKIPTTVQVSKVDENPYRVTCSRFMDISNIFKCEFVNPNIQVCFKTDLEI---SRSLSSS 432
            :.|::.|:...:..|.......|...:.:|:|..    |.: |..::.:..|.|:   |...:..
  Fly     6 VLEYVAKVVRALITSAKPPVTLRSIVADYMEIEG----EPI-PFRRLGYSNDQELLKDSNQFNFH 65

  Fly   433 PKGEITFLTSS-SSSKENFDPHSRKLLLAQNSKLKKATQVSQSQK---------------KRGKN 481
            ..|...|:|:. :::.|:.....|:...::::.|.|.|.::|..|               :|.|.
  Fly    66 QSGNQVFITAKYNANTEHIVRMVRQQKTSKSTSLSKPTPIAQKPKPIAQKHTHGNKYHYQQRNKQ 130

  Fly   482 AT-----EVAQSSLNSTAAIIDEFPAKDL------DFLHNFSSLD----------------ITKR 519
            ..     |:.:::.....||.:.  .:||      :...:|:::.                ||:|
  Fly   131 PNHQPDQEIGRAAKCENQAIAEH--KQDLTGIITQELFESFNNIQGPFSENLQVFNKNPEYITRR 193

  Fly   520 NKTTEDSSDWFK----------------------TDTL-VRVRSVQSPEDFYVQGIHAAQRLREE 561
            .|..:...|..:                      |:|: |.:.:.::|    |...|..:.::..
  Fly   194 KKELKKEDDLDRGQITKEVAREKQKEKETRDRAVTETIFVTIENKKAP----VMNGHGPRHVKVA 254

  Fly   562 LDTFAHTLSDSSSVPPTIVVGQNYIIHHKDKDRYYRALVSQKLTNEN---LYNVFLTDIGVHLHV 623
            .....|   :....|...::|.:.....:|....|.:..|......:   :|.......||.::.
  Fly   255 NGQDKH---NDGKPPLRAILGNSASQRQQDTSTVYHSPESSFKRPRHPRVMYPGHQRTTGVSVNH 316

  Fly   624 RCSDFRVVPERISHLPYSAVHCSLSELMPKNGESEWDSKASAFLKQ-----------IVQNNPVR 677
            |   .:|.|:  |..|..||........|:..::...:||:  .|:           :|.|..|:
  Fly   317 R---LKVTPQ--SDAPTPAVAPITPPASPEYAQTTTAAKAT--YKEDIHGGQGETGNVVTNPKVK 374

  Fly   678 VIVK--------KALTYELHGVDLITSNYDTNISVRDSFLYCGLAISRD---GAPLWLPPAPTA- 730
            |.:|        ..|.:.....|.....|:....:|:  |:|.:.|:.|   ..|.......||
  Fly   375 VPLKFDPSLDPVSTLNFYCAANDFEKPAYNIFNKLRN--LHCSVQIAGDVYSSYPQEFTDKETAY 437

  Fly   731 -----LRLPRI----------SFRFGDVYMVQMLHVEDPQEFYVMRHDY----EKKRLWLQFSLQ 776
                 :.:.||          :..|.||..:..|:.|      :::|.:    .|...|...:.:
  Fly   438 QRTAQIAIQRIMHAQSHQKLSACTFSDVEFIDGLYKE------LLKHPHGILGHKLEDWYGSTFR 496

  Fly   777 EAM------------------------------------DRINISQLQNIFLGQLHLGCVLQSGG 805
            :.:                                    ||.:|:.|.     |:.|......||
  Fly   497 QHLPSHWYDLIVKSNKIRVEHGIDPRIILFANDPGSSEPDRTSITTLP-----QMVLPWQSSEGG 556

  Fly   806 Q----------------WKR-----ASIEQI-----------------------------LPDGY 820
            .                |.|     |:.|::                             :|||:
  Fly   557 SHDWNMFISFCDSTKIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPYAQEVYLVEMPDGW 621

  Fly   821 VLV--------------HLVDEGPSQKVFWDQLFVLPQKFWDTGLAIKC---CLA--DVETRAEH 866
            ..|              |.:|.|.......:.||..|.:|    ||:..   ||:  .::...:|
  Fly   622 NRVRAISVDEETRSGRYHFIDFGDVAMFHSEDLFHCPPQF----LALPAQAVCLSMYALDKFEDH 682

  Fly   867 SY-----TWTPEGTTLFKQLTSNPRLYMDVISCTEDLVYVSLHFERSNSETTSVGVQLVAHGHCT 926
            .:     |...:|.|:...:.:..:.::::....:.:|
  Fly   683 PHALQVLTKELDGQTVVAHVLTTEKQFLELGGSAQGVV--------------------------- 720

  Fly   927 SSGESSRMITPTVSNRSVRFDEETKKFIAQQ--KVRPVELSPYRMPDNTERNKRTTVNILYVRKP 989
            .:|:....:..|:.:.|...|......:|::  |..|..    .:.|..:..|.|.:.:.::...
  Fly   721 ENGKRRACLVATLYDTSTAEDIHLNDLVAKRITKCTPAP----SLSDEKKIGKTTPILVSHINDD 781

  Fly   990 DEFYVTLPHFQKAINNLQKSVQKAAAAMYQNMLPRTDWQVGDMCYARVQANCDSQA----LWYRG 1050
            .:..|.|.      |:..|.|:::.|....::..:......|:.:.|....||...    .|:||
  Fly   782 GDLMVLLR------NDDLKFVERSIAQTVADLGEQDRVSYSDLLHDRHIFVCDETVDGVKQWFRG 840

  Fly  1051 -VVTGVIPPGITCPIVRYQVHLRDLGELIDD-----VHSSSLANIDEADMRISS---SAKRCHLH 1106
             :||..:.|......|.|          :||     .|.|::..::..:..:::   .|....||
  Fly   841 RLVTRPLNPDEESFDVYY----------VDDGRQRKAHISNIYRLEANNRALATFPPQAIPVRLH 895

  Fly  1107 GIRPIGDEWSKDAIDFFMDQLKAYNEIHVTGRG----RTENSLSVILWGSLSILTGPF---SPAT 1164
            .:..||..        .:.:|          ||    |||..|.|:.......|...|   .|.:
  Fly   896 DVPEIGGH--------MLHRL----------RGLIPWRTEALLKVVAMDGGKPLVNVFIREDPES 942

  Fly  1165 IKYVNINKAL-LMAGMAEKDHNSDSEDDQQSMPENVSVNSEEAAKANDWESCLSKIDGTSKTNDS 1228
            : |:.:|..| |...||...|           ||                    |.|.|
  Fly   943 M-YMCVNIGLRLELEMASSIH-----------PE--------------------KYDHT------ 969

  Fly  1229 LNLIESRSVTVGFEHNEDMPPLALLEDLGNTKNTTGE---TTPPAGWTTRRK----CDKSVFTAI 1286
              |:.|         |..:|.......:.:.::::.:   ||||.  |..:|    ...|.|:::
  Fly   970 --LLSS---------NVQLPRRGSFSSVFSNQSSSSDLVATTPPV--TPEKKPSARSTGSTFSSL 1021

  Fly  1287 ---------ATNVTYECCIYLTLASDKPFIEHMGNLLVREYK------PLMDKQKERSTSYTYK- 1335
                     |....:|..:.|::        :.|:..|:.||      .||...:|.......|
  Fly  1022 MLKDYEAIPAVGAYFEVRVALSV--------NPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAAKG 1078

  Fly  1336 -------VGQAVVV-----TYHMDNM--IYRGIVQRLENNHNEYTVYYVDYGNMELVKADEMLPY 1386
                   :|:|...     .||..::  ||..|:.          |.:||.|:..::..|::...
  Fly  1079 VQPSQLAIGEAYAAPDSEGVYHRVSIHKIYDEIIH----------VRFVDVGDDGVIACDQLKTL 1133

  Fly  1387 AP-FPDLNAMCFLVELHGVR------SKQGKYSLKEMDTVHLNLVMKLSGV-------------- 1430
            .| ...|..|....:|:|::      ||:.....:|     |:|..|..|:
  Fly  1134 NPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRE-----LSLGQKFIGIVRRMTKQKDGGRAL 1193

  Fly  1431 --RIVDDETVGPNKIPKCQIKVGNVDIAT 1457
              .:||..|....|:.:..|...:...||
  Fly  1194 CLELVDTSTPKDIKLHEILINEKHAQPAT 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	20/114 (18%)
		TUDOR	741..859	CDD:278965	34/226 (15%)
		TUDOR	<805..839	CDD:119391	12/97 (12%)
		TUDOR	981..1107	CDD:278965	24/138 (17%)
		TUDOR	1296..1403	CDD:278965	25/128 (20%)
		TUDOR	1337..1385	CDD:119391	12/54 (22%)
		TUDOR	1710..1761	CDD:119391
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586	16/89 (18%)
		TUDOR	563..673	CDD:278965	19/113 (17%)
		TUDOR	766..896	CDD:278965	26/145 (18%)
		TUDOR	1032..1151	CDD:278965	26/136 (19%)
		TUDOR	1087..1131	CDD:119391	12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910