DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and krimp

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster

Alignment Length:	808	Identity:	163/808 - (20%)
Similarity:	271/808 - (33%)	Gaps:	226/808 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 YCMKCYRSHCQICSTVHHSGHRIRKLIEINQSYASEIPTTLNSLNMAHIHVLNGKQVVQRAKQKL 283
            |..:.::.|.::...:.|:....|.||.::    ..:..:|:.:| ||:..||.:..:.|...:|
  Fly    27 YQTEMHQIHKELTEKLSHADLLYRSLIPLH----DHLVASLSEVN-AHVMKLNVQLHINRQSVRL 86

  Fly   284 NDYATETLASISKRFSHLHGLLQVAELQ-VIEKLRESSLP--------------PQLKLNEA--M 331
            .||.... .||...:|.:...||..|.. ..|.:.:||.|              |.:.:.||  .
  Fly    87 GDYEYYE-KSIDNPYSSIRSGLQAIEKPGCAEAICQSSKPAFVECLPSSTSEEVPVVAVQEASST 150

  Fly   332 GQLSGYETVIERLTKSLNSGVGNDMAVPRDVSLRWLLKLICEH----LEKIPT----TVQVSKVD 388
            .||.....|.|.|::. .......:||.:::..........|.    ||:||.    .|:..|.:
  Fly   151 NQLDAISVVNENLSEE-RDATPQPLAVSKNMEETMPSNPFHEQLEGSLEEIPVGSKIVVETEKAN 214

  Fly   389 ENPYRVTCS--RFMDISNIFKCEFVNPNI--QVCFKTDLEISRSLSSSPKG----EITFLTSSSS 445
             ||.|...|  ...|..::...:.....|  .:|.|    ||:|..:.|..    ..|.:|::|.
  Fly   215 -NPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNK----ISKSTINMPNNWQLENPTEVTAASI 274

  Fly   446 SKEN---FDPHSRKLLLAQNSKLKKATQVSQSQKKRGKNAT--EVAQSSLNSTAAIIDEFPAKDL 505
            .|.|   ..|.:|.||                ..|.|...|  ::....|...||    ||...:
  Fly   275 EKVNKLPKSPRNRFLL----------------PPKGGTETTRRDIYNQILKDMAA----FPENTI 319

  Fly   506 DFLHNFSSLDITKRNKTT---EDSSDWFKTDTLVRVRSVQSPEDFYVQGIHAAQRLREELDTFAH 567
             .....:|:|:|......   ::|||..|     :|...|.|       :....:|.:..|.||
  Fly   320 -VTAVLASVDVTDNCAYVAKWDESSDRIK-----KVLQRQLP-------LQELDQLPDYGDIFA- 370

  Fly   568 TLSDSSSVPPTIVVGQNYIIHHKDKDRYYRALVSQKLTNENLYNVFLTDIGVHLHVRCSD--FRV 630
            .|...:::...|.:..:                    :....|:.:|.|.|.|:|...::  |:
  Fly   371 VLDSINNIITRITINSS--------------------SAGGGYDAYLIDFGEHIHFDGNETIFK- 414

  Fly   631 VPERISHLPYSAVHCSLSELMPKNGESEWDSKASAFLK-QIVQNN---------------PVRVI 679
            :|:.|..||..|:.|.|......|    .....:.::| ::.:||               |.:..
  Fly   415 LPDDIKRLPAQAIRCDLINCDIAN----MHCFVNTYIKIRVHENNNSTLVAEPVIDRLSRPTKTN 475

  Fly   680 VKK---ALTYE----LHGVDLITS-------------------NYDTNISVRDSFLYCGLAISRD 718
            ..|   .:|.:    |:.:|..||                   :||..::.......|..|..
  Fly   476 TTKYPAGITEDDMAMLNEIDESTSDPLKAVLGFRPKDEQRICRHYDPKLNGCFKGNNCRFAHE-- 538

  Fly   719 GAPLWLPPAPT--------ALRLPR------ISFRFGDVYMVQMLHVEDPQEFYVMRHDYEKKRL 769
                  |.||.        |..||.      :.|..|.:..:.:..:..|.|.|....|.....:
  Fly   539 ------PFAPNGATKDVELARALPETIFDTTVHFEIGSIVGILITFINGPTEVYGQFLDGSPPLV 597

  Fly   770 WLQFSLQEAMDRINISQLQNIFLGQ---LHLGCVLQSGGQWKRASIEQILPDGYVLVHLVDEGPS 831
            |         |:.::.:.:..|..:   |.:...|.|.|.:.||.|....|..|::.: ||.|
  Fly   598 W---------DKKDVPENKRTFKSKPRLLDIVLALYSDGCFYRAQIIDEFPSEYMIFY-VDYG-- 650

  Fly   832 QKVFWDQLFVLPQKFWDTGLAIKCCLADVET----RAEHSYTWTPEGTTLFKQLTSNPRLYMDVI 892
                            :|......|||..|.    :....:::..||....|.||     :...|
  Fly   651 ----------------NTEFVPLSCLAPCENVDSFKPHRVFSFHIEGIVRSKNLT-----HQKTI 694

  Fly   893 SCTEDLVYVSLHFERSNSETTSVGVQLV 920
            .|.|.|        :|....|.:.|.||
  Fly   695 ECIEYL--------KSKLLNTEMNVHLV 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	22/113 (19%)
		TUDOR	741..859	CDD:278965	23/120 (19%)
		TUDOR	<805..839	CDD:119391	9/33 (27%)
		TUDOR	981..1107	CDD:278965
		TUDOR	1296..1403	CDD:278965
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	25/138 (18%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	14/62 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000