DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and snd1

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_878285.3	Gene:	snd1 / 324404	ZFINID:	ZDB-GENE-030131-3124	Length:	913	Species:	Danio rerio

Alignment Length:	984	Identity:	191/984 - (19%)
Similarity:	331/984 - (33%)	Gaps:	327/984 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 ESEWDSKASAFLKQIVQNNPVRVIVKKALTYELHGVDLITSNYDTN-ISVRDSFLYCGLAISRDG 719
            :..|..:|..|:::.|....|...|:.. |.:.....::....||: .::.:|.:..|||:.|
Zfish    75 DEPWAFQAREFMRKKVIGKEVCFTVENK-TPQGREYGMVYLGKDTSGENIAESLVAEGLAMVR-- 136

  Fly   720 APLWLPPAPTALRLPRISFRFGDVYMVQMLHVEDPQEFYVMRHDYEKKRLW-----------LQF 773
                           |...|..:...|::..:||..:       ..||.||           |::
Zfish   137 ---------------REGIRGNNPEQVRLCDLEDQAK-------SSKKGLWSEGGGSHTIRDLKY 179

  Fly   774 SLQEAMDRINISQLQ--NIFLGQLHLGCVLQSGGQWKRASIEQILPDGYVLVHLVDEGPSQKVFW 836
            :::...:.::....:  |..:..:..||::::          .:||| |.||.::..|.....|
Zfish   180 TIENPRNFVDSLHQKPVNAIIEHVRDGCMVRA----------LLLPD-YYLVTVMLSGIKSPTF- 232

  Fly   837 DQLFVLPQKFWDTGLAIKCCLADVETRAEHSYTWTPEG-TTLFKQLTSNPRLYMDV----ISCTE 896
                                      :.|...:.|||. ....|..|.:..|..||    .||..
Zfish   233 --------------------------KREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCPN 271

  Fly   897 DLVY-VSLHFERSNSETTSVGVQLVAHG--HC--------TSSGESSRMITPTVSNRSVR----- 945
            .::. ..||   .|...|.:   |:..|  .|        |...|..|....:...|.||
Zfish   272 QVILGTILH---PNGNITEL---LLKEGFARCVDWSMAVYTQGAEKLRAAERSAKERKVRIWKDY 330

  Fly   946 ------FDEETKKFIAQ----------------QKVRPVELSPYRMP--DNTERNK------RTT 980
                  .|::.::|:|:                .:.:.:.||..|.|  :..|:||      |..
Zfish   331 VAPTANLDQKDRQFVAKVMQVVNADAIVVKLNSGEYKTIHLSSIRPPRLEGEEKNKDKDKRFRPL 395

  Fly   981 VNILYVRKPDEFY----------VTLPHFQKAINNLQKSV----QKAAAAMYQNMLPRTDWQVGD 1031
            .:|.|:.:..||.          ||:.:.:.|.|.::..|    ::..|.:          .:|.
Zfish   396 YDIPYMFEAREFLRKKLIGKKVNVTVDYIRAATNAMEMGVPAFPERTCATV----------TIGG 450

  Fly  1032 MCYARVQANCDSQALWYRGVVTGVIPPGITCPIVRYQVHLRDLGELIDDVHSSSLANIDEADMRI 1096
            :..|        :||..:|:.|          ::||:   :|     ||..||....:..|:.|.
Zfish   451 INIA--------EALVSKGLAT----------VIRYR---QD-----DDQRSSHYDELLAAEARA 489

  Fly  1097 SSSAKRCH------LHGIRPIGDEWSKDAIDFFMDQLKAYNEIHVTGRGRTENSLSVILWGSLSI 1155
            ..:.|..|      :|.:..|..|..| |..||....:|         ||:|..:..:..||...
Zfish   490 IKNGKGLHSKKEVPIHRVADISGETQK-AKQFFPFLQRA---------GRSEAVVEYVFSGSRLK 544

  Fly  1156 LTGPFSPATIKYVNINKALLMAGMAEKDHNSDSEDDQQSMPENVSV---NSEEAA---------- 1207
            |..|.....|.:       |:||:       :.....::||..:.|   .||||.
Zfish   545 LYMPKETCLITF-------LLAGI-------ECPRGSRNMPGGMQVAEPYSEEAMLFTKELVLQR 595

  Fly  1208 ----------KANDWESCLSKIDGTSKTNDSLNLIESRSVTVGF--EHNEDMPPLALLEDLGNTK 1260
                      ||.::...| .|:|   .|.|:.|:|:....|.|  |.:.....|...|:....:
Zfish   596 EVEVEVESMDKAGNFIGWL-HIEG---VNLSVALVENALSKVHFTAERSSYYKTLVSAEESARQR 656

  Fly  1261 NTTGETTPPAGWTTRRKCDKSVFTAIATNVTYECCIYLT--------LASDKPFIEHMGNLLVRE 1317
                :....|.:..:.|.:.:..|.....|.....:|:|        .|.|......:.||: ..
Zfish   657 ----KEKLWANYEEKPKEEVAQVTEAKERVAKYRSVYVTEITDGLHFYAQDVETGTKLENLM-ES 716

  Fly  1318 YKPLMDKQKERSTSYTYKVGQAVVVTYHMDNMIYRGIVQRLENNHNEYTVYYVDYGNMELVKADE 1382
            .:..:..|.....|:..:.|:..:..: .|...||..|:::|:....: |:|:||||.|::.:..
Zfish   717 MRGEIAAQPPVEGSFAPRRGEFCIAKF-ADGEWYRARVEKVESPAKVH-VFYIDYGNREVLSSTR 779

  Fly  1383 M-----------LP---------YAPFP---------------DL-NAMCFL-VELHGVRSKQGK 1410
            :           ||         |...|               |: |..|.| ||..|  |...:
Zfish   780 LAALPPAFSTRTLPPQATEYAFAYIQVPQDEDARADAVDSVVRDIHNTQCLLNVEYSG--SVCPQ 842

  Fly  1411 YSLKEMDTVHLNLVMKLSGVRIVDDETVGPNKIPKCQIKVGNVDIATMMIDSGMSVPIEKQTIKN 1475
            .:|:..||                .|.||          :|.|....:|:|    :..||...|.
Zfish   843 VTLQFADT----------------KEDVG----------LGLVKEGMVMVD----IRKEKYLQKM 877

  Fly  1476 NTKYLPSQK 1484
            .|:||.:|:
Zfish   878 VTEYLNAQE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965
		TUDOR	741..859	CDD:278965	19/130 (15%)
		TUDOR	<805..839	CDD:119391	8/33 (24%)
		TUDOR	981..1107	CDD:278965	27/145 (19%)
		TUDOR	1296..1403	CDD:278965	31/151 (21%)
		TUDOR	1337..1385	CDD:119391	13/58 (22%)
		TUDOR	1710..1761	CDD:119391
snd1	NP_878285.3	SNc	18..167	CDD:214615	23/116 (20%)
		SNc	26..167	CDD:238102	23/116 (20%)
		SNc	194..329	CDD:214615	35/178 (20%)
		SNc	202..329	CDD:238102	34/170 (20%)
		SNc	342..498	CDD:214615	36/191 (19%)
		SNc	351..499	CDD:238102	35/183 (19%)
		SNc	528..663	CDD:214615	32/156 (21%)
		SNc	536..663	CDD:238102	29/148 (20%)
		TUDOR	680..802	CDD:278965	24/124 (19%)
		TUDOR	732..787	CDD:197660	13/56 (23%)
		SNc	749..898	CDD:214615	40/171 (23%)
		SNc	<847..898	CDD:294094	16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810