Protein Alignment qin and Rnf17

DIOPT Version :10

• Sequence 1: NP_650735.3
• Gene: qin / 42236
• FlyBaseID: FBgn0263974
• Length: 1857
• Species: Drosophila melanogaster
• Sequence 2: NP_001028215.1
• Gene: Rnf17 / 30054
• MGIID: 1353419
• Length: 1640
• Species: Mus musculus
• Alignment Length: 1994
• Identity: 402/1994 - (20%)
• Similarity: 678/1994 - (34%)
• Gaps: 672/1994 - (33%)

  Fly    18 SNLQNLLRCPKCSKCFTYLYNTNSEEDNHRPFLLGCGHTLCESCLWNDRLDP------KCAVC-- 74
            |..|....| :|::|...:  :.:..|:|:   ..|||..||.||    |.|      ||..|
Mouse    20 SGAQGASGC-QCTRCGRKV--SVASGDHHK---FPCGHAFCELCL----LAPQEYTTSKCTDCEV 74

  Fly    75 ---------HSPA-------------PPTIVAKRSDCKSVANLRDLYELNYHVLGRTSSLSYLLP 117
                     |.|.             ||.:|   ::|.|  :|....:...:.|..:||:.
Mouse    75 HTTVSMNQGHYPVDGFIEEDSSLEALPPKMV---NNCSS--DLEKTVDQLINDLEHSSSIH---- 130

  Fly   118 FAKDSANQSLSPSSISEIVQTVKCSECGNATASGECRQCNAFYCRRCFDAVHKRSRVLKSHIFRN 182
              ::.:|.|...|...||.:.:|.:.|.....|      ||.   :..|:...::| .::|....
Mouse   131 --RNVSNPSAVMSETEEIDEALKIAGCNFEQLS------NAI---KMLDSTQDQTR-QETHSLTE 183

  Fly   183 STEQDSSFSKKLRVGDQYFTL------PSQNLCIHHRMPKDKYCMKCYRSHCQICSTVHHSGHRI 241
            :.|:            |:.||      ..::||
Mouse   184 AVEK------------QFDTLLASLDSRKKSLC-------------------------------- 204

  Fly   242 RKLIEINQSYASEIPTTLNSLNMAHIHVLNGKQVVQRAKQKLNDYATETLASISKRFSHLHGLLQ 306
            .:||.....|.|::.|.              |..::..|..|     :....|:|.......|..
Mouse   205 EELIRRTDDYLSKLVTV--------------KSYIEEKKSDL-----DAAMKIAKELRSAPSLRT 250

  Fly   307 VAEL-QVIEKLR---ESSL----------PPQLKLN--EAMGQLSGYETV-IERLTKSLNSGVGN 354
            ..:| |:|..|:   ||.|          .|:|.:|  ||:...|....: .|..||.......:
Mouse   251 YCDLTQIIRTLKLTFESELSQVSSIIPRNTPRLDINCSEAICMFSSMGKIEFEDSTKCYPQENED 315

  Fly   355 DMAVPRDVSLRWLLKLICE-----HLEKIPTTVQVSKVDENPYR--------------------- 393
            ...|.:..:.|  .:|.|:     ..:|:...|...:..|.|.:
Mouse   316 GQNVQKKFNNR--KELCCDVYSSLEKKKVDAAVLTDETPEPPLQAEAPDRHLEGKKKQPTKEMVV 378

  Fly   394 VTCSRFMDI-------SNIFKCEFVNPNIQVCFKTD-LEIS-------RSLSSSPKG------EI 437
            ||..:.:.:       .::...|.:..|::.||..| :|.|       :...|:|.|      |:
Mouse   379 VTSPKTIAVLPQLGSSPDVIIEEIIEENLESCFTDDPIETSGYPKKPPQKEQSAPVGSKAGCPEL 443

  Fly   438 TFLTSSSSSKENFDPHSRKLLLAQNSKLKKATQVSQSQKKRGKNATEVAQSSLNSTAAIIDEFPA 502
            .|::...        |.....:.:.|::|.||.:.:..|       :|...||:.
Mouse   444 VFVSHVI--------HPCHFYVRKYSQIKDATILEKKMK-------QVCNRSLHL---------- 483

  Fly   503 KDLDFLHNFSSLDITKRNKTTEDSSDWFKTDTLVRVRSVQSPEDFYVQGIHAAQRLREELDTFAH 567
                                  |.||..:....:.|.|:::  ..:.:||     :.|
Mouse   484 ----------------------DPSDILELGARIFVNSIKN--RMWCRGI-----ITE------- 512

  Fly   568 TLSDSSSVPPTIVVGQNYIIHHKDKD-RYYRALVSQKLTNENLYNVFLTDIG------------V 619
                              ||..|.|: |...:.....:...:|..:|:.|.|            .
Mouse   513 ------------------IIPSKTKNIRKPCSPTKFSVCEISLIQIFMVDFGNSEVLIITGVGDT 559

  Fly   620 H--------LHVRCSDFRVV--------PERISHLPYSAVHCSLSELMPKNGESEWDSKASA-FL 667
            |        .|:..|||.::        .|.:..:|:.|..|||.:::|.|....|:.:|.. ||
Mouse   560 HEGPEHDGEQHITLSDFCLLLMKSEPYSEELLKDIPHLAHLCSLKDIVPYNSTEGWEKEAKVEFL 624

  Fly   668 KQIVQNNPVRVIVKKALTYELHG-------VDL-------ITSNYDTNISVRDSFLYCGLAISRD 718
            |         ::.|||:..::.|       |||       |:|  |..:|:||:.::..||..|.
Mouse   625 K---------MVNKKAVLMKVFGEEDDVLIVDLQKPPTNKISS--DMPVSLRDALVFMELARFRS 678

  Fly   719 GAPLWLPPAPTAL--RLPRISFRFGDVYMVQMLHVEDPQEFYVMRHDYEKKRLWLQFSLQEAMDR 781
            .:|.......|.|  ..|.:.....:| .|.:.|:..|.:||:              .|.|.:|.
Mouse   679 QSPRSHSEKNTTLCYHPPILPEEMTEV-SVMVCHINSPTDFYL--------------QLMENLDF 728

  Fly   782 IN-ISQLQNIFLGQ----LHLGCVLQS--------GGQWKRASIEQILPDGYVLVHLVDEGPSQK 833
            :: :..::..:.|:    |.:.|.||:        .|.|.||.:..:.....|.|..||.|.:.|
Mouse   729 LSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAK 793

  Fly   834 V-------FWDQLFVLPQKFWDTGLAIKCCLADVETRAEHSYTWTPEGTTLFKQLTSNPRLYMDV 891
            :       ..|:....|:|      ||||.||.||...:..  |:.:....|::.|.:..:...|
Mouse   794 ITLKDMRKIKDEFLEPPEK------AIKCKLAYVEPSKKSQ--WSKKAKEKFEEKTQDKFVTCSV 850

  Fly   892 ISCTE-DLVYVSLHFERS-NSETTSVGVQLVAHGHCTSSGESSRMITPTVSNRSVRFDEETKKFI 954
            |...| :::.|.|...|: .....|:..|||..|  .:|.|:...:..........:|...::.|
Mouse   851 IKILENNVLLVELFDSRAPGKSAVSINDQLVKEG--LASYEAGYTLKDNSKKHLEVWDPSPEEII 913

  Fly   955 AQQKVRPVELSPYRMPDNTER---NKRTTVNILYVRKPDEFYVTLPHFQKAINNLQKSVQKAAAA 1016
            ..:......||...:|:...:   ||...|||..|..|::.||.....:..:|:|:   :|..||
Mouse   914 TSEINNLSPLSVKSLPNENFQSLYNKELPVNICNVISPEKIYVQWLLTENLLNSLE---EKMVAA 975

  Fly  1017 MYQNMLPRTDWQVGDMCYARVQANCDSQALWYRGVVTGVIPPGITCPIVRYQVHLRDLG-ELIDD 1080
            ...:......|:....|..:|.|    :..|.||.:..::...:.      :|.|.|:| ||:.:
Mouse   976 YEHSEWKPVKWECDMHCAVKVPA----KNQWRRGQILRMVTDKLV------EVLLYDVGVELVVN 1030

  Fly  1081 VHSSSLANIDEADMRISSSAKRCHLHGIRPIG--DEWSKDAIDFFMDQLKAYNEIHVTGRGRTEN 1143
            :|  .|..:.|....:...:..|.|..|||.|  |:|:..|.|..        .:|:||...|
Mouse  1031 IH--CLRELQENLKTMGRLSLECSLVDIRPTGGSDKWTATACDCL--------SLHLTGAIAT-- 1083

  Fly  1144 SLSVILWGSLSILTGPFSPATI-------KYVNINKALLMAGMAEKDHNSDSEDDQQSMPENVSV 1201
               :||..|.:  |.|. |..|       :.|:::|.|:..|:|.::.......:..|..:::.:
Mouse  1084 ---IILQESNT--TWPL-PVKIFCRDEKGERVDVSKYLIKKGLALRERRVSKSSNSHSPEKSLEI 1142

  Fly  1202 NSEEAAKANDWESCLSK-----IDGTSKTNDSLNLIESRSVTVGFEHNEDMPPLALLEDLGNTKN 1261
            ..|:.      :|.::|     .|...|..|.:|           ||.        :.|....|:
Mouse  1143 PLEQG------DSVVTKCFKINFDTNKKIADKVN-----------EHK--------VPDSKGKKS 1182

  Fly  1262 ---TTGETTPPAGWTTRRKCDKSVFTAIATNVTYECCIYLTLASDKPFIEHMGNLLVREYKPLMD 1323
               :||...|||...|      |.|.||.|      ||     .|...|..:..|...|...:||
Mouse  1183 ESRSTGCYRPPAVPNT------SSFEAIVT------CI-----GDDGTIFVVPKLSEFELIKMMD 1230

  Fly  1324 KQKER------STSYTYKVGQAVVVTYHMDNMIYRGIVQRLENNHNEYTVYYVDYGNMELVKADE 1382
            :.:..      ...|::|.|:...|. ..|.:.|||.|  :|.......|.|:|:|..|.:....
Mouse  1231 EIQSNLKCLGLLEPYSWKKGEPCAVR-GSDTLWYRGKV--MEVVGGTIRVQYLDHGFTEKIPQCH 1292

  Fly  1383 MLPYAPFPDLNAMCFLVELH------------GVRSKQGKYSLKEMDTVHLNLVMKLSGVRIVDD 1435
            :.|...:||....|...:|:            .:...|...|.:|:| :|   :|:|
Mouse  1293 LYPILLYPDTPQFCIPCQLYQTLPVGNTWQPDAIELLQELLSKREVD-IH---IMEL-------- 1345

  Fly  1436 ETVGPNKIPKCQIKVGNVDIATMMIDSGMS----VPIEKQTIKNNTKYLPSQKFL--------ED 1488
                ||.      ..|.:.:  .:...|||    :...|..|..:|:.:..:|..        |:
Mouse  1346 ----PNN------SWGKLSV--HLYFDGMSLSHFMAHHKYCIFEHTEEIFKEKPRGQNKKYEDEN 1398

  Fly  1489 FKV-FDELDHLAAGEGELSDKEAP--PTQRKHDSISSVQQPPTKKFLVDQEEVEAFECDQDFDCQ 1550
            :|: |::|        .|.:.|||  |..     :||:..||.:.|.|..:.:  ...|:.:.|
Mouse  1399 WKIRFEDL--------LLPEMEAPVLPPY-----LSSLLPPPEELFAVQVKHI--VSPDEMYIC- 1447

  Fly  1551 QAAQKMHLNNNFYLGDFGKYADETTARDEDEPHSNSSKSIDMEVFA---NVNDSQLEPLNSFATE 1612
                   |::......|..:.|     .:|...|..|:|.::|...   |.|.....||..|::|
Mouse  1448 -------LDSEDSYTQFNHHGD-----TDDSGVSWESESENLEEALQRFNKNVETFPPLTDFSSE 1500

  Fly  1613 QLIRRIALRQQEIKDSITFSPIDTSSVRSFYDASASFKTLSLPNGVKEFYCTVDNVLSDTELQIA 1677
            .
Mouse  1501 M---------------------------------------------------------------- 1501

  Fly  1678 PCLSEFTKHEISLIQETSTLIKDAEPLMEPKVGDLCLARYSRDKQWYRA---NIKEISPILSPTS 1739
            |||:|:.                                   |..||||   :|||.:|:
Mouse  1502 PCLAEYA-----------------------------------DGLWYRAKIISIKEFNPL----- 1526

  Fly  1740 EQVTVFYIDFHDTEKVSFNHLKVMPSQLFMFPLRSFCVKLHGIK 1783
             .|.|.::|:..|||::.|.|:.:|.||..:|.::..|.|.|.|
Mouse  1527 -SVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFK 1569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..76	CDD:434085	17/67 (25%)
		Bbox1	140..178	CDD:380815	7/37 (19%)
		Bbox2	208..244	CDD:380814	2/35 (6%)
		TUDOR	536..648	CDD:425754	24/140 (17%)
		TUDOR	742..859	CDD:425754	32/136 (24%)
		Tudor_SF	989..1139	CDD:470623	37/152 (24%)
		TUDOR	1296..1403	CDD:425754	27/124 (22%)
		TUDOR	<1703..1781	CDD:425754	23/80 (29%)
Rnf17	NP_001028215.1	PRK03918	87..>273	CDD:235175	46/269 (17%)
		CC_brat-like	158..>242	CDD:475168	22/156 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..376		2/27 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..435		5/21 (24%)
		Tudor_TDRD4_rpt1	490..565	CDD:410485	15/106 (14%)
		Tudor_TDRD4_rpt2	728..823	CDD:410486	25/100 (25%)
		Tudor_TDRD4_rpt3	968..1049	CDD:410487	20/95 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1170..1191		7/39 (18%)
		Tudor_TDRD4_rpt4	1247..1314	CDD:410488	19/69 (28%)
		Tudor_TDRD4_rpt5	1494..1598	CDD:410489	32/181 (18%)