DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and Tdrd1

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	XP_038959137.1	Gene:	Tdrd1 / 292129	RGDID:	1306140	Length:	1174	Species:	Rattus norvegicus

Alignment Length:	1186	Identity:	254/1186 - (21%)
Similarity:	421/1186 - (35%)	Gaps:	309/1186 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SANQSLSPSSISEIVQTVKCSECGNATASGECRQCNAFYCRRCFDAVHKRSRVLKSHIFRNSTEQ 186
            |.|.....:|:...:::..|..|| ...|..|.||...|  .|..|..:|.
  Rat   143 SVNNPALFNSLGPPLRSTTCHRCG-LFGSLRCSQCKQTY--YCSTACQRRD-------------- 190

  Fly   187 DSSFSKKLRVGDQYFTLPSQNLCIHHRMPKDKYCMKCYRSHCQICSTVHHSGHRIR--------K 243
                                                 :.||..||..|..|.|::.        |
  Rat   191 -------------------------------------WSSHSTICRPVQQSLHKLEDNKSPFETK 218

  Fly   244 LIEI-NQSYASEIPTTLNSLNMAHIHVLNGKQVVQ-RAKQKLNDYATETLASISKRFSHL-HGLL 305
            .|:: |:..|..:..|......|...:.:..:.:| |...::....||        |.|. |..:
  Rat   219 TIDVKNEQVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTE--------FKHPGHFYV 275

  Fly   306 QVAELQVIEKLRESSLPPQLKLNEAMGQLSGYETVIERLTKSLNSGVGNDMAVPRDVSLRWLLKL 370
            |:...:|:               |.|.|||.          ||.....|  .||.|..|
  Rat   276 QLYSSEVL---------------EYMNQLSA----------SLKETYAN--MVPEDGYL------ 307

  Fly   371 ICEHLEKIPTTVQVSK--VDENPYRVTCSRFMDI----SNIFKCEFVNPNIQVCFKTDL--EISR 427
                  .:...|.|:|  ||:...|..... :|:    :::...::.|..|   ...|.  ::||
  Rat   308 ------PVKGEVCVAKYTVDQTWNRAVVEG-VDVLQKKAHVLYIDYGNEEI---IPVDRIHQLSR 362

  Fly   428 SLSSSPKGEITFLTS-----SSSSKENFDPHSRKLLLAQNSKLKKATQVSQSQKKRGKNATEVA- 486
            |:|..|...|....|     :....|:.....:.||..|...:|   .|..|:::....|.:|.
  Rat   363 SISLFPPSAIKCYVSGVVPAAGEWTEDCVVAVKALLFEQYCSIK---VVDISEEEGLTCAVDVVL 424

  Fly   487 QSSLNSTAAIIDEF--------PAKDLDFLHNFSSLD---ITKRNKTTEDSSDWFKTDTLVR--- 537
            |||......::.|.        |:.....:...:|.|   :|..|:...:.:....|...:.
  Rat   425 QSSGKQLDHVLVEMGYGVKPDEPSSKKQSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGD 489

  Fly   538 -----VRSVQSPEDFYVQGI---HAAQRLREELDTFAHTLSDSSSVPPTIVVGQNYIIHHKDKDR 594
                 |..:|:||||:.|.:   |....|:|.|..:...::..|...|||  |........:.|:
  Rat   490 EFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHVTPRSDFYPTI--GDMCCAQFSEDDQ 552

  Fly   595 YYRALVSQKLTNENLYNVFLTDIG----VHLHVRCSDFRVVPERISHLPYSAVHCSLSELMPKNG 655
            :|||.|....:.|::. |...|.|    :.|...|.   ::| ::..||..|::|.|:.:.|..|
  Rat   553 WYRASVLAYASEESVL-VGYVDYGNFEILSLKRLCP---IIP-KLLDLPMQALNCVLAGVKPSLG 612

  Fly   656 ESEWDSKASAFLKQIVQNNPVRVIV-----KKALTYELHGVDLITSNYDTNISVRDSFLYCGLAI 715
              .|..:|...:::.|||..|.|.|     .:||      |:|:..:...::|...:.|..|.||
  Rat   613 --MWTPEAICVMRKAVQNRMVTVRVVGMQGTRAL------VELVDKSVAPHLSASKALLDSGFAI 669

  Fly   716 SR-------------DGAPLWLPPAPTALRLPRISFRFGDVYMVQMLHVEDPQEFY--VMRHDYE 765
            ..             ...||.:..|...|....:.|...:...|.:..:..|.|||  .::.|..
  Rat   670 EEKDIVADKGSSARASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDAL 734

  Fly   766 KKRLWLQFSLQEAMDRINIS-------QLQNIFLGQLHLGC--VLQSGGQWKRASIEQILPDGYV 821
            ||           :|.:|.|       :..|.|..::...|  .....|.|.||.:::|||.|.|
  Rat   735 KK-----------LDDLNKSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNV 788

  Fly   822 LVHLVDEGPSQKVFWDQLF-VLPQKFWDTGLAIKCCLADVETRAEHSYTWTPEGTTLFKQLTSNP 885
            .||.||.|..::|..|||. :.||........::|.|.|::.:.:|   ||.|.|..|:......
  Rat   789 KVHFVDYGNVEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKH---WTKEATARFQACVVGL 850

  Fly   886 RLYMDVISCTEDLVYVSLHFERSNSETTSVGVQLVAHG---HCTSSGESSRMITPTVSNRSVRFD 947
            :|...|:..||:.|.|.| .:.|......:...|:...   .|.|..:...|..|  :|:..:.|
  Rat   851 KLQARVVEITENGVGVEL-TDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRP--ANKHNQID 912

  Fly   948 EETKKFIAQQKVRPVELSP-------YRMPDNTERNKRTTVNILYVRKPDEFYV---TLPHFQKA 1002
            .::           |:.||       ..:|    .||....|:|.:..|..||.   .:|..|:.
  Rat   913 SQS-----------VQASPPAEQWKTIELP----VNKTVPANVLEIISPTLFYAIPSEMPENQEK 962

  Fly  1003 INNLQKSVQKAAAAM-----YQNMLPRTDWQVGDMCYARVQANCDSQALWYRGVVTGVIPPGITC 1062
            :..|...:.:...|.     |:   |||    |:.|.|: ..|.|   .|||.:|.......:
  Rat   963 LCVLTAELLEHCNAQKGQPPYR---PRT----GEACCAK-YTNDD---FWYRAIVLEASDSDV-- 1014

  Fly  1063 PIVRYQVHLRDLGELIDDVHSSSLANIDEADMRISSSAKRCHLHGIRPIGDEWSKDAIDFFMD-- 1125
                 :|...|.|. ::.:..|.:..|..:.:::.....||.|.|:..:....|:..::...:
  Rat  1015 -----KVLYADYGN-VERLPFSRVQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVMELLRNAM 1073

  Fly  1126 -------QLKAYNE-IH-VTGRGRTENSLSVILWGSLSILTGPFSPATIKYVNINKALLMAGMAE 1181
                   .:||.:: :| |:....:||.:                      :||.:.|:|.|:||
  Rat  1074 LNQSVALSVKAVSKNVHAVSVEKCSENGM----------------------INIAENLVMCGLAE 1116

  Fly  1182 KDHNSDSEDDQQSMPE 1197
               |..|:.:..|..|
  Rat  1117 ---NLSSKRESASTKE 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662	11/34 (32%)
		TUDOR	536..648	CDD:278965	32/126 (25%)
		TUDOR	741..859	CDD:278965	36/129 (28%)
		TUDOR	<805..839	CDD:119391	16/33 (48%)
		TUDOR	981..1107	CDD:278965	30/133 (23%)
		TUDOR	1296..1403	CDD:278965
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
Tdrd1	XP_038959137.1	zf-MYND	162..198	CDD:396356	13/89 (15%)
		Tudor_TDRD1_rpt1	262..391	CDD:410479	37/179 (21%)
		Tudor_TDRD1_rpt2	512..593	CDD:410480	21/87 (24%)
		TUDOR	709..825	CDD:395449	35/126 (28%)
		Tudor_SF	938..1053	CDD:413384	30/133 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007887
OrthoInspector	1	1.000	-	-		otm46004
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810