DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and Tdrd5

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	XP_006250099.1	Gene:	Tdrd5 / 289129	RGDID:	1307078	Length:	1046	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	188/919 - (20%)
Similarity:	318/919 - (34%)	Gaps:	287/919 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 HRIRKLIEINQS--------YASEIPTTLNSLNMAHIHVLNGKQVVQRAKQKLNDYATETLASIS 295
            |::|..::..:|        |...:|..|.::..:.:     |.::..:...|:|:.........
  Rat    98 HKVRNSMQKGRSSVCSGRVPYRGRVPPILPAVVKSEL-----KDLLALSPVLLSDFEKAFARRFG 157

  Fly   296 KRFSHL-HGLLQVAELQ-------VIEKLRESSLPPQLKLNEA--------------------MG 332
            :.|.:: :|.|.:.|:.       .:|:.|..||   |.|.::                    |.
  Rat   158 RSFQYMQYGFLSMFEVLSAASDVICVEQTRAGSL---LTLKKSASEEKQREWPAGKIFTQPFRMK 219

  Fly   333 QLSGYETVIERLTKSLNSGVGNDMAVPRDVSLRWLLKLICEHLEKIP--TTVQVSKVDENPYRVT 395
            |...|.|... :||:..|...::|..|:.|.          .:||||  .||:.|::...
  Rat   220 QQGSYSTGFP-VTKTRFSQPISNMEPPKQVL----------SMEKIPMFNTVEASRLSHT----- 268

  Fly   396 CSRFMDISNIFKCEF--------VNPNIQ-------VCFKTDLEISRSLSS---------SPKGE 436
             .:...:.:.||...        |:|:::       ..|...|.||:.|..         ||| :
  Rat   269 -EKLNQLESTFKSVIAQIGPGGTVDPDLKHKIKFVVSKFPQGLFISKLLGEFELVFKEQLSPK-Q 331

  Fly   437 ITFLTSS--------------SSSKEN---FDPHSRKLL------------LAQNSKLKKATQVS 472
            :.||..:              |..|::   ||...|.||            |.|..|..:|...:
  Rat   332 LGFLNVTELVGALSDILRVEFSEEKQDLLVFDADLRPLLPAGPLSSVRNSCLVQPDKRIEANAWA 396

  Fly   473 QSQKKRG---------------KNATEVAQSSLNSTAAIIDEFPAKDLDFLHNFSSLDITKRNKT 522
            .|..:..               ||..|..|.:......::...   .|....|.|.|.::..|..
  Rat   397 SSPSRNSLSTVAVKKTTWDCPLKNHKEAEQKAYKKPNLVVKPL---QLQVETNKSQLSLSMANHD 458

  Fly   523 TEDSSDWFK---------TDTLVR--VRSVQSPEDFYVQGIHA--AQRLREEL-----DTFAHTL 569
            ....:...|         |.|||.  |..:.||..|||: |::  :..|.|::     ..:::.|
  Rat   459 IPPDAVRAKKLCRLPPLDTSTLVGVFVEYIISPSQFYVR-IYSRDSSELLEDMMIEMRRCYSNQL 522

  Fly   570 SDSSSVPPTIVVGQNYIIHHK-DKDRYYRALVSQKLTNENLYNVFLTDIGVHLHVRCSDFRVVPE 633
            .....|.|...:...::...: .:|:::..::..::..:....||..|.|....|:.|..|.:..
  Rat   523 VSDRYVMPEYFIQPGHLCCVRISEDKWWYRVIIHRILGKKEVEVFYPDFGNIGTVQKSSLRFLKC 587

  Fly   634 RISHLPYSAVHCSLSELMPKNGESEWDSKASAFLKQIVQNNPVRVIVKKALTYELHGVDLITSNY 698
            ..:.||..|:.|||:.:.|  .|..|.|||....:::....|:..:|.:.       :|.|.:.:
  Rat   588 CYTKLPAQAIPCSLAWVRP--AEEHWTSKAILHFQKLCGLKPLVGVVDEY-------IDGILNIF 643

  Fly   699 --DTNISVRDSFLYCGL------AISRDGAPL-----WLPPA--PTALRLPRISFRFGDVYMVQM 748
              ||: |..|.:.:..|      .:.|:.||.     :.|||  ..:...|      ||:.:.::
  Rat   644 LCDTS-SNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNPPALYTNSSAAP------GDMVLTEL 701

  Fly   749 LHVEDPQEFYVMRHDYEKKRLWLQFSLQEAMDRINISQLQNIF--------LGQLHLGCVLQSGG 805
            .|   |.:.:.:..|.|    .||...|:..|..:||.|:::.        ||.|......:...
  Rat   702 GH---PAQQHYLNEDGE----ILQQPQQDINDEKSISHLKSVSEELLKDSKLGPLKTRESCEEEP 759

  Fly   806 QWK-------RASIEQILPDGYVLVHLV-------DE-------------GPSQKVFWDQL---- 839
            ||.       :...|..:|.|...:..|       ||             ||:..:|...|
  Rat   760 QWSILKPKDPKEENEDEVPTGMPCLESVTIGDDIWDENWLPLQAKMGKAGGPASHLFTSSLVGKK 824

  Fly   840 --------------FVLPQKFWD-----TGLAIKCCLADVETRAEHSYTWTPE---------GTT 876
                          |...:..||     .|||     .||:.|     |.|||         |||
  Rat   825 QYQTRGETTRKDWCFSTSKDIWDDSWQPLGLA-----NDVKGR-----THTPEGPIAQEKNIGTT 879

  Fly   877 LFKQLTSNPRLYMDVISCT----EDLVYVSL-----HFERSNSETTSVGVQLVAHGHCTSSGESS 932
               ::...|.|...:.|.|    |:. |:||     ..|.|.||..|:...| ..|..:|:..||
  Rat   880 ---RIRKQPDLQYPLDSSTLPKLEEF-YISLIKSQQSAEGSQSEPASIQTPL-KPGQASSTAPSS 939

  Fly   933 RMITPTVSN 941
               ||...:
  Rat   940 ---TPAAGD 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	26/121 (21%)
		TUDOR	741..859	CDD:278965	34/175 (19%)
		TUDOR	<805..839	CDD:119391	11/60 (18%)
		TUDOR	981..1107	CDD:278965
		TUDOR	1296..1403	CDD:278965
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
Tdrd5	XP_006250099.1	LOTUS_1_TDRD5	4..98	CDD:193599	188/919 (20%)
		LOTUS_2_TDRD5	127..196	CDD:193589	13/76 (17%)
		LOTUS_3_TDRD5	292..365	CDD:193590	15/73 (21%)
		TUDOR	483..602	CDD:278965	25/119 (21%)
		TUDOR	537..583	CDD:119391	7/45 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740