Protein Alignment qin and SND1

DIOPT Version :10

• Sequence 1: NP_650735.3
• Gene: qin / 42236
• FlyBaseID: FBgn0263974
• Length: 1857
• Species: Drosophila melanogaster
• Sequence 2: NP_055205.2
• Gene: SND1 / 27044
• HGNCID: 30646
• Length: 910
• Species: Homo sapiens
• Alignment Length: 857
• Identity: 169/857 - (19%)
• Similarity: 308/857 - (35%)
• Gaps: 262/857 - (30%)

  Fly  1169 NINKALLMAGMAEK---------DHNSDSEDDQQSMPENVSVNSEEAAKANDWESCLSKIDGTSK 1224
            ||.::|:..|:|.:         :.|..||.::|:          :|||...|    |:.:|:..
Human   122 NIAESLVAEGLATRREGMRANNPEQNRLSECEEQA----------KAAKKGMW----SEGNGSHT 172

  Fly  1225 TNDSLNLIESRSVTVGFEHNEDMPPLALLEDLGN---------------TKNTTGETTPPAGWTT 1274
            ..|....||:....|...|.:  |..|::|.:.:               |...:|...|    |.
Human   173 IRDLKYTIENPRHFVDSHHQK--PVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCP----TF 231

  Fly  1275 RRKCDKS----VFTAIATNVTYECCIYLTLASDKPFIEHMGNLLVREYKPLMDKQKERS------ 1329
            ||:.|.|    .|.|.|                |.|.|  ..||.|:.:.:::....::
Human   232 RREADGSETPEPFAAEA----------------KFFTE--SRLLQRDVQIILESCHNQNILGTIL 278

  Fly  1330 ------TSYTYKVGQAVVVTYHMDNMIYRGIVQRL--------ENNHNEYTVYYVDYGNMELVKA 1380
                  |....|.|.|..|.:.:  .:|....::|        |.....:..|.....|::  :.
Human   279 HPNGNITELLLKEGFARCVDWSI--AVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLD--QK 339

  Fly  1381 DEMLPYAPFPDLNAMCFLVELHGVRSKQGKYSLKEMDTVHLN----------------------- 1422
            |:.........|||...:|:|:     .|.|.     |:||:
Human   340 DKQFVAKVMQVLNADAIVVKLN-----SGDYK-----TIHLSSIRPPRLEGENTQDKNKKLRPLY 394

  Fly  1423 -----------LVMKLSGVRI---VD--------DETVGPNKIPKC-QIKVGNVDIATMMIDSGM 1464
                       |..||.|.::   ||        .|||.......| .:.:|.::||..::..|:
Human   395 DIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGINIAEALVSKGL 459

  Fly  1465 SVPIE-KQTIKNNTKYLPSQKFLEDFKVFDELDHLAA-------GEGELSDKEAPPTQRKHDSIS 1521
            :..|. :|.....:.:            :|||  |||       |:|..|.||. |..|..|...
Human   460 ATVIRYRQDDDQRSSH------------YDEL--LAAEARAIKNGKGLHSKKEV-PIHRVADISG 509

  Fly  1522 SVQQPPTKKFLVDQEEVEAFECDQDFDCQQAAQKMHLNNNFYLGDFGKYADETT--ARD------ 1578
            ..|:  .|:||...:.....|...::....:..|::|.....|..|.....|..  ||:
Human   510 DTQK--AKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQ 572

  Fly  1579 EDEPHSNSS----------KSIDMEV-----------FANVNDSQLEPL---------------N 1607
            |.||.|..:          :.:::||           :.:::.:.|..|               :
Human   573 EGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVEHALSKVHFTAERS 637

  Fly  1608 SFATEQLIRRIALRQQEIKDSITF--SPI-DTSSVRSFYDASASFKTLSLPNGVKEFYCTVDNVL 1669
            |:....|....|.:|::.|....:  .|: :...|....:.|||:|.:.:.....:.:..|.:|.
Human   638 SYYKSLLSAEEAAKQKKEKVWAHYEEQPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVE 702

  Fly  1670 SDTELQIAPCLSEFTKHEISLIQETSTLIKDAEPLME----PKVGDLCLARYSRDKQWYRANIKE 1730
            :.|:|:   .|.|..:::|:           :.|.:|    |:.|:.|:|::. |.:||||.:::
Human   703 TGTQLE---KLMENMRNDIA-----------SHPPVEGSYAPRRGEFCIAKFV-DGEWYRARVEK 752

  Fly  1731 ISPILSPTSEQVTVFYIDFHDTEKVSFNHL---------KVMPSQLFMFPLRSFCVKLHGIKRNK 1786
            :.   ||.  ::.|||||:.:.|.:....|         :|:|:|...:......|......|..
Human   753 VE---SPA--KIHVFYIDYGNREVLPSTRLGTLSPAFSTRVLPAQATEYAFAFIQVPQDDDARTD 812

  Fly  1787 SFKEKSVRQALQACLC----QHPLVFARVHYPLNYYPNRPNCDADLIE--VELYENRHEKKLVYQ 1845
            :.  .||.:.:|...|    :| |.....|..|.:..::.:....|::  :.:.|.|.||:  :|
Human   813 AV--DSVVRDIQNTQCLLNVEH-LSAGCPHVTLQFADSKGDVGLGLVKEGLVMVEVRKEKQ--FQ 872

  Fly  1846 SLCENWMFLKKS 1857
            .:...::..::|
Human   873 KVITEYLNAQES 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..76	CDD:434085
		Bbox1	140..178	CDD:380815
		Bbox2	208..244	CDD:380814
		TUDOR	536..648	CDD:425754
		TUDOR	742..859	CDD:425754
		Tudor_SF	989..1139	CDD:470623
		TUDOR	1296..1403	CDD:425754	22/126 (17%)
		TUDOR	<1703..1781	CDD:425754	24/90 (27%)
SND1	NP_055205.2	SNc	21..166	CDD:214615	13/57 (23%)
		SNc	193..328	CDD:214615	28/160 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	321..325		0/3 (0%)
		SNc	350..496	CDD:238102	34/169 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	388..392		0/3 (0%)
		SNc	525..660	CDD:214615	21/134 (16%)
		Tudor_TDRD11	703..785	CDD:410504	25/101 (25%)
		SNc	<844..895	CDD:469627	7/43 (16%)