Protein Alignment qin and TDRD6

DIOPT Version :10

• Sequence 1: NP_650735.3
• Gene: qin / 42236
• FlyBaseID: FBgn0263974
• Length: 1857
• Species: Drosophila melanogaster
• Sequence 2: NP_001010870.1
• Gene: TDRD6 / 221400
• HGNCID: 21339
• Length: 2096
• Species: Homo sapiens
• Alignment Length: 1775
• Identity: 338/1775 - (19%)
• Similarity: 567/1775 - (31%)
• Gaps: 615/1775 - (34%)

  Fly   433 PKGEITFLTSSSSSKENFDPHSRKL--LLAQNSKLKKATQVSQSQKKRG--------------KN 481
            |...:.||    |:.:..:.|...|  ||.....|.:...|.|..::.|              :.
Human   151 PADAVDFL----SNLQGKEVHGCVLDVLLLHRLVLLEVPDVFQQMRELGLARRVPDSLFRSLLER 211

  Fly   482 ATEVAQSSLNSTAAIIDEFPAKD----LDFLHNFSSLDITKRNKTTEDSSDWFKTDTLVRVRSVQ 542
            ....|.:|:.|...::...|.|.    ||:.:....|.:|:                .|.:..|.
Human   212 YLTAATASVGSGVPVLSRVPLKQKQPGLDYFYPQLQLGVTE----------------AVVITQVC 260

  Fly   543 SPEDFYVQGIHAAQRLREELDTFAHTLSDSSSVPPTIVVGQNYIIHHKDKDR------------- 594
            .|...:.|....:|.:....::.|.....|:...........:....:..|:
Human   261 HPHRIHCQLRSVSQEIHRLSESMAQVYRGSTGTGDENSTSATWEEREESPDKPGSPCASCGLDGH 325

  Fly   595 YYRALVSQKLTNENLYNVFLTDIGVHLHVRCSDFRVVPERISHLPYSAVHCSLSELMPKNGESEW 659
            :||||:.:....:....|...|.|....|.||..|.:......:|.....|:|..|.  :|...|
Human   326 WYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLW--DGGRGW 388

  Fly   660 DSKASAFLKQIVQNNPVRVIVKKALTYE------LHGVDLITSNYDTNISVRDSFLYCGLA---- 714
            .......||.::....|...::...::|      |:|.|.|..|....:.      .|.||
Human   389 SRSQVGDLKTLILGKAVNAKIEFYCSFEHVYYVSLYGEDGINLNRVFGVQ------SCCLADRVL 447

  Fly   715 -----------ISRDGAP-------LWLPPAPTALRLPRISFRFGDVYMVQMLHVEDPQEFYV-- 759
                       .|:..:|       :.||    |||  .|..:....|..|:..|::|.||::
Human   448 QSQATEEEEPETSQSQSPAEEVDEEISLP----ALR--SIRLKMNAFYDAQVEFVKNPSEFWIRL 506

  Fly   760 MRHDYEKKRLWLQFSLQEAMDRI-----NISQLQNIFLGQL--HLGCVLQSGGQWK-----RASI 812
            .:|:....:|         |.|:     :.|:|..:.|...  .|.||     :||     ||.:
Human   507 RKHNVTFSKL---------MRRMCGFYSSASKLDGVVLKPEPDDLCCV-----KWKENGYYRAIV 557

  Fly   813 EQILPDGYVLVHLVDEGPSQKVFW-DQLFVLPQKFWDTGLAIKCCLADVETRAEHSYTWTPEGTT 876
            .: |.|..|.|.|||.|.|:.|.| |...:|||......||:||.|||:....:   ||:.|..:
Human   558 TK-LDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGK---TWSQEAVS 618

  Fly   877 LFKQLTSNPRLYMDVISCTEDLVYV--SLHFERSNSET-----------------TSVGVQLVAH 922
            .||:...:..|.:.::. .:|..||  .|...|:..|.                 |...:.:.||
Human   619 FFKKTVLHKELVIHILD-KQDHQYVIEILDESRTGEENISKVIAQAGYAKYQEFETKENILVNAH 682

  Fly   923 --GHC---------------TSSGE-------SSRMITPTVSNRSVRFDEETKKFIAQQKVRP-- 961
              ||.               |..||       .:..::..:|:.:|..:..| :.:.|:||:.
Human   683 SPGHVSNHFTTESNKIPFAKTGEGEQKAKRENKTTSVSKALSDTTVVTNGST-ELVVQEKVKRAS 746

  Fly   962 ---------VELSP-YRMPDNTERNKRTTVNILYVRKPDEFYVTLPHFQKAINNLQKSVQ---KA 1013
                     :|:.| .......|......|.:.||..|..|:..|....:.:..|...:|   |.
Human   747 VYFPLMQNCLEIKPGSSSKGELEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKN 811

  Fly  1014 AAAMYQ-NMLPRTDWQVGDMCYARVQANCDSQALWYRGVVTGVIPPGITCPIVRYQVHLRDLGEL 1077
            .||.:| |.|         .|.|:...|    ..|.|.:::|:      ..:....|...|.|:.
Human   812 TAAPHQRNTL---------ACLAKRTVN----RQWSRALISGI------QSVEHVNVTFVDYGDR 857

  Fly  1078 IDDVHSSSLANIDEADMRISSSAKRCHLHG-IRPIGDE---WSKDAIDFFMDQLKAYNEIHVTGR 1138
             :.|...::.:|.|..:::.:.|.||.|:. |:|:|..   |...||       :|:||.
Human   858 -EMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGQNPFVWDVKAI-------QAFNEF----- 909

  Fly  1139 GRTEN----------------SLSVILWGSLSILTGPFSPATIKYVNINKALLMAGMAEKDHNSD 1187
              .:|                |::..|:..:.:|| ||..|.  :..:.|.|
Human   910 --IDNAWQKNLELKCTIFALASINEELFNIVDLLT-PFQSAC--HFLVEKRL------------- 956

  Fly  1188 SEDDQQSMPENVSVNSEEAAKANDWESCLSKIDGTSKTNDSLNLIESRSVTVGFEHNEDMPPLAL 1252
                  :.|..:....|.:.:.:.:                  ...:..:.:|   :|::..:..
Human   957 ------ARPVKLQKPLESSVQLHSY------------------FYSTHDMKIG---SEELVYITH 994

  Fly  1253 LEDLGNTKNTTGETTPPAGWTTRRKCDKSVFTAIATNVTYECCIYLTLASDKPFIEHMGNLLVRE 1317
            ::|               .||                      .|..||.:...:|.:...:.:.
Human   995 IDD---------------PWT----------------------FYCQLARNANILEQLSCSITQL 1022

  Fly  1318 YKPLMDKQKERSTSYTYKVGQAVVVTYHMDNMIYRGIVQRLENNHNEYTVYYVDYGNMELVKADE 1382
            .|.|::.:.......|      :.:..:.|...|||||...|..    .|::||:||:.:|.:|:
Human  1023 SKVLLNLKTSPLNPGT------LCLAKYTDGNWYRGIVIEKEPK----KVFFVDFGNIYVVTSDD 1077

  Fly  1383 MLP-------------------YAPFPD------------------LNAM--------CFLVELH 1402
            :||                   .:..||                  |.|:        ..::||:
Human  1078 LLPIPSDAYDVLLLPMQAVRCSLSDIPDHIPEEVVVWFQETILDKSLKALVVAKDPDGTLIIELY 1142

  Fly  1403 G--------VRSKQGKYSLKEMDTVHLNLVMKLSGVRIVDDETVGPNKIPKCQIKVGNVDIATMM 1459
            |        :..|.|..|.|:      .:..|.|.|.....||:...
Human  1143 GDNIQISASINKKLGLLSYKD------RIRKKESEVLCSTTETLEEK------------------ 1183

  Fly  1460 IDSGMSVPIEKQTIKNNTKYLPSQKFLED---------FKVFDELDHLAA---------GEGELS 1506
             :..|.:|..:...|:....||:::.||:         :|....|..|..         ..|..:
Human  1184 -NENMKLPCTEYLSKSVGYKLPNKEILEESYKPQINSSYKELKLLQSLTKTNLVTQYQDSVGNKN 1247

  Fly  1507 DKEAPPTQRKHDSISSVQQPPTKKFLVD---QEEVEAFECDQDFD---C---------------- 1549
            .:..|.|..|.:.||:  :.|.|...|:   .|......||:|..   |
Human  1248 SQVFPLTTEKKEEISA--ETPLKTARVEATLSERKIGDSCDKDLPLKFCEFPQKTIMPGFKTTVY 1310

  Fly  1550 ---------------QQAAQKMHLNN---------NFYLGDFGKYADETTA---RD--------- 1578
                           :..|:..||:.         .:|:|...:..|...|   .|
Human  1311 VSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIK 1375

  Fly  1579 EDEP-----------------HSNSSKSIDM-----------------EVFANVNDSQ------- 1602
            |.:|                 |:|....:|:                 ||..|.|..:
Human  1376 EQQPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDNKNSKKMMHYFSQ 1440

  Fly  1603 ---------------------LEPLNSFATEQLIRRIALRQ--------QEIKD----SITFSPI 1634
                                 |...:....:.:|.|.||.:        |.||.    |:..|.|
Human  1441 RTSEAAIRCEFVKFQDRWEVILADEHGIIADDMISRYALSEKSQVELSTQVIKSASSKSVNKSDI 1505

  Fly  1635 DTSSVRSFYDAS----ASFKTLSLPNGVKEFYCTVDNVLSDTE-LQIAPCLSEFTKHEISLIQET 1694
            |||...::|:..    .::.|:.  :|.:.|:|.    .:||| ||   ||      |:. :|..
Human  1506 DTSVFLNWYNPEKKMIRAYATVI--DGPEYFWCQ----FADTEKLQ---CL------EVE-VQTA 1554

  Fly  1695 STLIKDAEPLME-PKVGDLCLARYSRDKQWYRANIKEISPILSPTSEQVTVFYIDFHDTEK-VSF 1757
            ...:.|....:. |.:||.|:.||..|..:|||.|..|.     ....|:|..:||.:.|. |..
Human  1555 GEQVADRRNCIPCPYIGDPCIVRYREDGHYYRALITNIC-----EDYLVSVRLVDFGNIEDCVDP 1614

  Fly  1758 NHLKVMPSQLFMFPLRSFCVKLHGI---------KRNKSFKEKSVRQALQACLCQHPLVFARVHY 1813
            ..|..:||:|...|:::|...|.|.         :.|..|.|......|:..:.:
Human  1615 KALWAIPSELLSVPMQAFPCCLSGFNISEGLCSQEGNDYFYEIITEDVLEITILE---------- 1669

  Fly  1814 PLNYYPNRPNCDADLIEVEL 1833
                 ..|..||..|..|:|
Human  1670 -----IRRDVCDIPLAIVDL 1684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..76	CDD:434085
		Bbox1	140..178	CDD:380815
		Bbox2	208..244	CDD:380814
		TUDOR	536..648	CDD:425754	21/124 (17%)
		TUDOR	742..859	CDD:425754	40/131 (31%)
		Tudor_SF	989..1139	CDD:470623	36/157 (23%)
		TUDOR	1296..1403	CDD:425754	29/151 (19%)
		TUDOR	<1703..1781	CDD:425754	25/79 (32%)
TDRD6	NP_001010870.1	Tudor_TDRD6_rpt1	6..136	CDD:410491
		Tudor_TDRD6_rpt2	240..380	CDD:410492	25/155 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..316		2/28 (7%)
		Tudor_TDRD6_rpt3	488..622	CDD:410493	46/151 (30%)
		Tudor_TDRD6_rpt4	815..893	CDD:410494	21/97 (22%)
		Tudor_SF	975..1100	CDD:470623	28/192 (15%)
		Tudor_TDRD6_rpt6	1306..1420	CDD:410496	13/113 (12%)
		Tudor_TDRD6_rpt7	1521..1663	CDD:410497	43/162 (27%)